Astemizole Pharmacology

Astemizole

About Astemizole
Non-sedating selective H1-receptor antagonist, anticholinergic, antihistamine,antipruritic.
Mechanism of Action of Astemizole
Thisa histamine H1-receptor antagonist competitively binds to receptors on the gastrointestinal tract, uterus, blood vessels, and bronchial muscle. This suppresses the activation of receptors by histamine which produces allergic symptoms like itching, edema and pruritis etc
Pharmacokinets of Astemizole
Absorption- Rapidly absorbed after oral administration
Distribution- Widely distributed in the body.96% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excreted via feces
Onset of Action for Astemizole
N/A
Duration of Action for Astemizole
24 hrs
Half Life of Astemizole
Its plasma half life is 1 day
Side Effects of Astemizole
1. Difficulty breathing
2. Closing of throat
3. Swelling of lips, tongue, or face
4. Hives
5. Irregular heartbeat
6. Fainting
7. Seizures.
8. Drowsiness
9. Dizziness
10. Headache
11. Nervousness
12. Nausea
13. Diarrhea
14. Abdominal discomfort
15. Dry mouth
16. Dry skin
17. Itchiness.
Contra-indications of Astemizole
Contraindicated in patients with
1. Hypersensitivity to the drug
2. Porphyria
Special Precautions while taking Astemizole
Use with caution in patients with
1. Prostatic neuropathy
2. Urinary retention
3. Glaucoma
4. Pyloroduodenal obstruction
5. Epilepsy
6. Cardiac disease
7. Prolonged QT interval
8. Hypokalemia
9. Any work which require mental alertness
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Astemizole
1. Rash
2. Hives
3. Watery eyes
4. Runny nose
5. Itching eyes
6. Sneezing
7. Conjunctivitis
8. Pruritis
Interactions for Astemizole
Alcohol, MAOIs, CNS Depressants: Effects potentiated.
Food: Astemizole absorption reduced by 60 % Should be taken empty stomach or 2 hours after a meal.
Typical Dosage for Astemizole
Oral-
General dose
Adult- 10mg once daily
Children (6-12 yrs) - 5mg once daily
Take astemizole on an empty stomach, 1 hour before or 2 hours after eating food.
Schedule of Astemizole
H
Storage Requirements for Astemizole
Store at room temperature away from moisture and heat.
Effects of Missed Dosage of Astemizole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Astemizole
Give symptomatic and supportive treatment.

Home Delivery for Astemizole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including astemizole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for astemizole and other medicines and health products. Home delivery services for astemizole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take astemizole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for astemizole before they complete the sale. You can get this information while placing the order for astemizole with the pharmacy.

Astemizole is a generic medicine name and there are several brands available for it. Some of the brands for astemizole might be better known than astemizole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have astemizole in stock, you can ask for one of the branded alternatives for astemizole.