Rupatadine Fumarate Pharmacology

Rupatadine Fumarate

About Rupatadine Fumarate
A second generation histamine H1 and platelet-activating factor (PAF) antagonist , Antihistamine.
Mechanism of Action of Rupatadine Fumarate
Rupatadine has double mechanism of action. It acts as a long-acting, non-sedative antagonist at histaminergic H1-receptors by competitively binding to it which are present on uterus, bronchus and large blood vessels etc.It also, antagonizes the platelet-activating factor (PAF). Both histamine and PAF causes bronchoconstriction and lead to an increase in the vascular permeability, acting as a mediator in the inflammatory process, which is responsible for the bronchial hyper reactivity. Drug has other anti-allergic properties also, such as inhibition of mastocytes, degranulation, induced by the immunological and non-immunological stimulants and the inhibition of release of cytokines, particularly the tumor necrosis factor alpha (TNF-alpha) in human mastocytes and monocytes.
Pharmacokinets of Rupatadine Fumarate
Absorption-Rapidly absorbed after oral administration. Distribution- Widely distributed in the body. Highly bound to plasma proteins (99%). Metabolism- Metabolized in the liver to its metabolites. It also undergo presystemic metabolism.
Excretion- Excreted via urine and faeces.
Onset of Action for Rupatadine Fumarate
N/A
Duration of Action for Rupatadine Fumarate
N/A
Half Life of Rupatadine Fumarate
N/A
Side Effects of Rupatadine Fumarate
1. Sleepiness
2. Weakness
3. Fatigue
4. Dry mouth
5. Pharyngitis
6. Dyspepsia
7. Increase in appetite
8. Rhinitis
Contra-indications of Rupatadine Fumarate
1. Contraindicated in patients with hypersensitivity to Rupatadine or any of the excipients.
Special Precautions while taking Rupatadine Fumarate
1. Renal insufficiency
2. Hepatic insufficiency
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Rupatadine Fumarate
1. Asthma
2. Allergic intraocular inflammatory diseases
3. Atopic eczema
4. Inflammatory dermatoses
5. Pruritis
Interactions for Rupatadine Fumarate
Co-administration of 20 mg Rupatadine with the known CYP3A4 inhibitors Ketoconazole (200 mg,once daily)
Ketoconazole inhibits both the presystemic and systemic metabolism of Rupatadine, increasing about 10-fold the exposure of unchanged drug and decreasing the exposure of metabolites.
Typical Dosage for Rupatadine Fumarate
Oral-
Adult and children (>12yrs) -10mg once daily.
Schedule of Rupatadine Fumarate
N/A
Storage Requirements for Rupatadine Fumarate
Store in a cool and dark place.
Effects of Missed Dosage of Rupatadine Fumarate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Rupatadine Fumarate
Treated symptomatically together with the necessary support measures.

Home Delivery for Rupatadine Fumarate in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for rupatadine fumarate and other medicines and health products. Home delivery services for rupatadine fumarate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take rupatadine fumarate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for rupatadine fumarate before they complete the sale. You can get this information while placing the order for rupatadine fumarate with the pharmacy.

Rupatadine Fumarate is a generic medicine name and there are several brands available for it. Some of the brands for rupatadine fumarate might be better known than rupatadine fumarate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have rupatadine fumarate in stock, you can ask for one of the branded alternatives for rupatadine fumarate.