Auranofin (Gold) Pharmacology

Auranofin (Gold)

About Auranofin (Gold)
Organogold Compound, Antirheumatic.
Mechanism of Action of Auranofin (Gold)
It appears to reduce immune responsiveness. It inhibits the migration of mononuclear cells in area of inflammation. It also stabilize lysosomal membrane, hence damage to cartilage is prevented.
Pharmacokinets of Auranofin (Gold)
Absorption- 20-25% absorbed after oral administration
Distribution- Widely distributed in the body
Excretion- Excreted via urine and feces
Onset of Action for Auranofin (Gold)
N/A
Duration of Action for Auranofin (Gold)
N/A
Half Life of Auranofin (Gold)
Its plasma half life is 26 days
Side Effects of Auranofin (Gold)
1. Dermatitis
2. Stomatitis
3. Glossitis
4. Pharyngitis
5. Pruritis
6. Exfoliative dermatitis
7. Peripheral neuritis
8. Thrombocytopenia
9. Leucopenia
10. Renal damage
11. Hepatic damage
12. Encephalopathy
13. Stiffness
14. Muscle aches
15. Fatigue
16. Nausea
17. Vomiting
18. Weakness
19. Sweating
20. Palpitation
21. Flushing
22. Joint pain
Contra-indications of Auranofin (Gold)
1. Hypersensitivity to the gold
2. Hepatic dysfunction
3. Renal disease
4. History of infectious hepatitis
5. History of exfoliative dermatitis
6. Necrotizing enterocolitis
7. Bone marrow aplasia
8. Pulmonary fibrosis
9. Haematological disorders
Special Precautions while taking Auranofin (Gold)
Monitor blood counts & urinary protein regularly
Use with caution in patients with Women in reproductive age group (should use effective contraception during therapy and up to six months after therapy is stopped).
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Auranofin (Gold)
1. Rheumatoid arthritis
2. Juvenile arthritis
Interactions for Auranofin (Gold)
Phenytoin: Increase in phenytoin blood levels may occur.
Other nephrotoxic drugs: Increased risk of toxicity.
Typical Dosage for Auranofin (Gold)
Oral-
Adults-
6mg daily in two divided doses or as a single dose for minimum 3-6 months
If response is inadequate increase to maximum 3mg thrice daily
Intramuscular-
Adult-
Test dose- 10mg
Weekly dose - 50mg
In patient showing response doses should be increased gradually to 4 weeks and treatment continued for up to 5 years after complete remission.
Schedule of Auranofin (Gold)
H
Storage Requirements for Auranofin (Gold)
Store at room temperature, sealed, light- resistant container.
Effects of Missed Dosage of Auranofin (Gold)
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Auranofin (Gold)
Give symptomatic and supportive treatment. Adminitser corticosteroid, Dimercaprol or penicillamine for the recovery. If needed Dimercaprol give together with corticosteroids to facilitate the removal of gold.

Home Delivery for Auranofin (Gold) in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for auranofin (gold) and other medicines and health products. Home delivery services for auranofin (gold) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take auranofin (gold) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for auranofin (gold) before they complete the sale. You can get this information while placing the order for auranofin (gold) with the pharmacy.

Auranofin (Gold) is a generic medicine name and there are several brands available for it. Some of the brands for auranofin (gold) might be better known than auranofin (gold) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have auranofin (gold) in stock, you can ask for one of the branded alternatives for auranofin (gold).