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- Pharmacology For Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals
Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals Pharmacology
Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals
About Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/AMechanism of Action of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/APharmacokinets of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/AOnset of Action for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/ADuration of Action for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/AHalf Life of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/ASide Effects of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/AContra-indications of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/ASpecial Precautions while taking Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/AInteractions for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/ATypical Dosage for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/ASchedule of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/AStorage Requirements for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/AEffects of Missed Dosage of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/AEffects of Overdose of Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + MineralsN/AGlucosamine
About GlucosamineAmino sugar,Monosaccharide derivative, Anti-inflammatory,Antiarthritic.Mechanism of Action of GlucosamineIt stimulates cartilage cells to produce glucosaminoglycans and proteoglycans which are the building blocks of cartilage. This stops the progression of OA (osteoarthritis) and possibly reverses the process. It also has anti-inflammatory properties by its inhibition of proteolytic enzymes.Pharmacokinets of GlucosamineAbsorption- Well absorbed after oral administration
Distribution- Widely distributed into joint tissues
Excretion - Excreted through urine
Onset of Action for GlucosamineN/ADuration of Action for GlucosamineN/AHalf Life of GlucosamineN/ASide Effects of Glucosamine1. Epigastric pain
2. Tenderness
3. Heartburn
4. Diarrhoea
5. Nausea
6. Drowsiness
7. Headache
8. Insomnia
9. Vomiting
10. Constipation
11. Anorexia
12. Erythema
13. PruritisContra-indications of GlucosamineContraindicated in patients with hypersensitivity to the drugSpecial Precautions while taking Glucosamine1.Blood sugars carefully monitored because Glucosamine may increase insulin resistance
2.In normal and diabetic patients
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Glucosamine1. Osteo arthritis.
2. Rheumatoid arthritis
Interactions for GlucosamineN/ATypical Dosage for GlucosamineOral-
Adult:1200mg /day
Schedule of GlucosamineN/AStorage Requirements for GlucosamineStore in cool (<30 degree C) and dark placeEffects of Missed Dosage of GlucosamineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of GlucosamineGive symptomatic and supportive treatmentChondroitin Sulphate
About Chondroitin SulphateA sulfated glycosaminoglycan (mucopolysaccharides, Dietary supplement , anti-rheumatic and anti-inflammatory.Mechanism of Action of Chondroitin SulphateChondroitin sulfate is part of a large protein molecule (proteoglycan) that gives cartilage elasticity.
It stimulates cartilage cells to produce glucosaminoglycans and proteoglycans which are the building blocks of cartilage. This stops the progression of OA (osteoarthritis) and possibly reverses the process. It also has anti-inflammatory properties by its inhibition of proteolytic enzymes.Pharmacokinets of Chondroitin SulphateAbsorption- Well absorbed after oral administration
Distribution- Widely distributed into joint tissues
Excretion - Excreted through urine
Onset of Action for Chondroitin SulphateN/ADuration of Action for Chondroitin SulphateN/AHalf Life of Chondroitin SulphateN/ASide Effects of Chondroitin Sulphate1. Epigastric pain
2. Tenderness
3. Heartburn
4. Diarrhoea
5. Nausea
6. Drowsiness
7. Headache
8. Insomnia
9. Vomiting
10. Constipation
11. Anorexia
12. Erythema
13. PruritisContra-indications of Chondroitin SulphateContraindicated in patients with hypersensitivity to the drugSpecial Precautions while taking Chondroitin Sulphate1.Blood sugars carefully monitored because Glucosamine may increase insulin resistance
2.In normal and diabetic patientsPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Chondroitin SulphateN/AInteractions for Chondroitin SulphateN/ATypical Dosage for Chondroitin SulphateN/ASchedule of Chondroitin SulphateN/AStorage Requirements for Chondroitin SulphateStore in cool (<30 degree C) and dark placeEffects of Missed Dosage of Chondroitin SulphateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Chondroitin SulphateGive supportive measures and symptomatic treatment.Vitamin C
About Vitamin CWater soluble vitamin, antioxidant.Mechanism of Action of Vitamin CVitamin C exerts it`s action by influencing the biologic oxidations and reductions used in cellular respirations. It directly stimulates collagen synthesis and maintains intracellular connective tissue. It involves in various metabolic reactions such as 1).Hydroxylation of praline and lysine residues of protocollagen which is essential for formation and stabilization of collagen triple helix, 2).hydroxylation of carnitine, 3).Conversion of folic acid to folinic acid, 4).biosynthesis of adrenal steroids, catecholamines, oxytocin, and ADH, 5).Metabolism of cyclic nucleotides and prostaglandins. Vitamin C is important in resistance to infections.Pharmacokinets of Vitamin CAbsorption: Well absorbed orally.
Distribution: Widely distributed both extracellularly and intracellularly, It crosses the placenta and also distributed in to the breast milk.
Metabolism: Metabolized in the liver; partly oxidized in to active dehydroascorbic acid and inactive metabolites.
Excretion: Inactive metabolites and extra drug is excreted through urine.
Onset of Action for Vitamin CN/ADuration of Action for Vitamin CN/AHalf Life of Vitamin CN/ASide Effects of Vitamin C1. Discomfort at injection site
2. Acid urine
3. Renal calculi
4. Oxaluria
Contra-indications of Vitamin CNo known contraindicationsSpecial Precautions while taking Vitamin C1. Renal impairment
2. Ingestion of large doses during pregnancy has resulted in scurvy in neonates
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Vitamin C1. Scurvy
2. Prophylaxis and treatment of vitamin C deficiency
3. As an antioxidant to maintain natural colour and flavour of food items
4. For acidification of urine
5. Capillary fragility
6. Dental caries
Interactions for Vitamin COral contraceptives and estrogens: Vitamin C increases serum levels of oestrogen resulting in adverse reactions .
Warfarin: The anticoagulant effects of warfarin is reduced.
Lab Tests: Large doses (>500 mg) of vitamin C may cause false negative urine glucose determinations. May result in false negative amine dependent stool occult blood tests.Typical Dosage for Vitamin COral:
Adults: 50 to 1000mg/day depending up on the requirement.
Pregnancy and lactation: 100 to 150mg/day
Children: 30 to 100mg/day.
Scurvy:
Oral:
Adults: 1000mg twice daily to thrice daily.
Children: 300mg to 1000mg daily.
Sub clinical scurvy:
Oral, S.C., I.M., or I.V.: 100 to 250mg once daily or twice daily depending up on the severity of the condition. Then give a maintenance dosage of 50mg/day.
Children: 100 to 300mg depending up on the severity. Then give a maintenance dose of 35mg/day.
Schedule of Vitamin CC1 (Oral)
C (Parenteral)Storage Requirements for Vitamin CStore in a cool dry area in a well closed container. Protects from moisture, light and direct heat.Effects of Missed Dosage of Vitamin CTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vitamin CDiscontinue the therapy and provide symptomatic and supportive measures.Vitamin D3
About Vitamin D3N/AMechanism of Action of Vitamin D3Vitamin D3 is a form of vitamin D. It is also called as Cholecalciferol.7-Dehydrocholesterol is the precursor of vitamin D3 and only forms the vitamin after being exposed to UV radiation.After exposure to the sun, cholecalciferol is sent to the liver to be hydroxylated where it becomes 25-Hydroxyvitamin D3.Next, it is sent to the kidney and once again hydroxylated becoming 1,25-Hydroxyvitamin D3. 1,25-Hydroxyvitmain D3 is the active form of vitamin D3, for this reason vitamin D is often referred to as a prohormone.Vitamin D exerts it`s action by influencing calcium homoeostasis. It increases the intestinal absorption of calcium and phosphate. It binds to the cytoplasmic Vitamin D receptor and translocates to the nucleus and thus increases the synthesis of specific m RNA and regulates protein synthesis. It increases the synthesis of a carrier protein for calcium called "calbindin" or calcium binding protein. Activation of Vitamin D receptor enhances endocytotic capture of calcium and it`s transport across duodenal mucosal cells in a vesicular form. Vitamin D promotes resorption of calcium and phosphate from bone by enhancing recruitment and differentiation of osteoclast precursors in the bone remodeling units. It helps in bone mineralization.Pharmacokinets of Vitamin D3Absorption: Well absorbed orally in the presence of bile salts, Malabsorption and steatorrhoea interfere with it`s absorption.
Distribution: Widely distributed in a protein bound form. It is stored in adipose tissue and liver.
Metabolism: It is hydroxylated in to both active and inactive metabolites and also metabolized in kidney.
Excretion: Metabolites are excreted mainly through bile.
Onset of Action for Vitamin D3N/ADuration of Action for Vitamin D3N/AHalf Life of Vitamin D3N/ASide Effects of Vitamin D31. Hypercalcaemia
2. Fatigue
3. Weakness
4. Diarrhoea
5. Vomiting
6. Sluggishness
7. Albuminuria
8. Polyuria
9. Calcification of soft tissues (blood vessels, parenchymal organs including heart)
10. Arrhythmias
11. Renal stones
12. Growh retardation in children
13. Hypertension
14. Anorexia
15. Nausea
16. Constipation
17. Elevated liver enzymes
Contra-indications of Vitamin D31. Hypercalcaemia
2. Hypervitaminosis D
3. Renal osteodystrophy with hyperphosphatemia
4. Renal impairment
Special Precautions while taking Vitamin D31. Renal diseases
2. Renal stones
3. Cardiac diseases
4. Arteriosclerosis
5. Coronary diseases
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Vitamin D31. Rickets and Osteomalacia
2. Hypoparathyroidism
3. Fanconi`s syndrome
4. Osteoporosis
Interactions for Vitamin D3Antacids: Hypermagnesemia may develop in patients on renal dialysis who take magnesium containing antacids.
Digitalis glycosides: May precipitate cardiac arrhythmias due to hypercalcemia.
Verapamil: Atrial fibrillation may occur.
Cholestyramine: Intestinal absorption of Vitamin D may be reduced.
Mineral Oil: Prolonged use of mineral oil may result in reduced absoprtion of Vitamin D.
Phenytoin, Barbiturates: Half life of vitamin D may be reduced.
Thaizide diuretics: Hypoparathyroid patients on Vitamin D may develop hypercalcemia due to thiazide diuretics.
Typical Dosage for Vitamin D3Oral:
Adults:
Nutritional Rickets and Osteomalacia: 25 to 125mcg daily in normal gastrointestinal absorption. In severe malabsorption; 250mcg to 7.5mg orally or 250mcg I.M.
Vitamin dependent Rickets: 250mcg to 1.5mg daily
Hypoparathyroidism: 625mcg to 5mg daily with calcium supplements
Fanconi`s syndrome: 1.25 to 5mg daily
Osteoporosis: 25 to 250mcg daily or 1.25mg once weekly with calcium and fluoride supplements.
Hypophosphatemia: 250mcg to 1.5mg along with phosphate supplements
Children:
Nutritional Rickets and Osteomalacia: 25 to 125mcg daily in normal gastrointestinal absorption. In severe malabsorption; 250mcg to 625mcg orally
Vitamin dependent Rickets: 75 to 125mcg daily.
Fanconi`s syndrome: 625mcg to 1.25mg daily
Hypophosphatemia: 1 to 2mg daily with phosphate supplements. Increase the dose in increments of 250 to 500mcg at intervals of 3 to 4months until desired therapeutic response is obtained.
Schedule of Vitamin D3N/AStorage Requirements for Vitamin D3Store in a well closed container in a cool place. Protect from light and excess heat. Keep out of reach of children.Effects of Missed Dosage of Vitamin D3Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vitamin D3Provide supportive and symptomatic treatment. Stops the treatment and starting a low calcium diet. Increases the fluid intake and administer Loop diuretics like furosemide may be given with saline I.V. infusion to increase calcium excretion. Calcitonin may decrease hypercalcaemia. Vitamin E
About Vitamin EN/AMechanism of Action of Vitamin EVitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation.Pharmacokinets of Vitamin EAbsorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases.
Distribution: Widely distributed in a protein bound form and stored in adipose tissue.
Metabolism: Metabolized in liver by glucuronide conjugation.
Excretion: Excreted mainly through bile and also excreted through urine.
Onset of Action for Vitamin EN/ADuration of Action for Vitamin EN/AHalf Life of Vitamin EN/ASide Effects of Vitamin E1. Fatigue
2. Weakness
3. Headache
4. Nausea
5. Diarrhoea
6. Blurred vision
7. Flatulence
Contra-indications of Vitamin E1. Hypersensitivity to the drug
2. Should not administer intravenously
Special Precautions while taking Vitamin E1. Hepatic impairment
2. Gall bladder disease
3. Along with estrogens
Pregnancy Related InformationMay be usedOld Age Related InformationN/ABreast Feeding Related InformationMay be usedChildren Related InformationN/AIndications for Vitamin E1. Vitamin E deficiency
2. Intermittent claudication
3. Nocturnal muscle cramps
4. Coronary artery disease
5. Fibrocystic breast disease
6. Cystic fibrosis
7. In premature infants exposed to high concentration of oxygen
8. As antioxidant
Interactions for Vitamin EOral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.
Typical Dosage for Vitamin EOral:
Vitamin E deficiency:
Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency.
Children: 1 unit/kg/day.
Premature neonates: 5units daily.
Full term neonates: 5 units per liter of formula.
Intermittent claudication: 400mg/day for 12 to 18 weeks.
Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks.
Coronary artery disease: 100 to 200mg/day for at least 2 years.
Fibrocystic breast disease: 600mg/day for at least 2years.
Cystic fibrosis: 100 to 200mg/day.
Children above 1 year: 100mg/day.
Children below 1year: 50mg/day.
Schedule of Vitamin EC1Storage Requirements for Vitamin EStore in a well closed container in a cool dry place. Protect from light.Effects of Missed Dosage of Vitamin ETake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vitamin EProvide supportive measures and symptomatic treatment.Methyl sulfonyl methane
About Methyl sulfonyl methaneN/AMechanism of Action of Methyl sulfonyl methaneMSM has been proven to have anti-inflammatory and antioxidant mechanisms in an in vitro study6 in which human neutrophils were artificially stimulated to produce oxidative compounds, including hydrogen peroxide, superoxide, and hypochlorous acid. After cell lines were treated with either DMSO or DMSO2, these free radical by-products were decreased.Pharmacokinets of Methyl sulfonyl methaneN/AOnset of Action for Methyl sulfonyl methaneN/ADuration of Action for Methyl sulfonyl methaneN/AHalf Life of Methyl sulfonyl methaneN/ASide Effects of Methyl sulfonyl methane1.Nausea
2.Diarrhea
3.Bloating
4.Fatigue
5.Headache
6.Insomnia
7.Itching or worsening of allergy symptoms.
Contra-indications of Methyl sulfonyl methaneN/ASpecial Precautions while taking Methyl sulfonyl methaneN/APregnancy Related InformationNot recommendedOld Age Related InformationN/ABreast Feeding Related InformationNot recommendedChildren Related InformationN/AIndications for Methyl sulfonyl methane1.To reduce pain and swelling of the joints caused by osteoarthritis.
2.Interstitial cystitis
Interactions for Methyl sulfonyl methaneN/ATypical Dosage for Methyl sulfonyl methaneOral: For osteoarthritis: 500 mg three times daily up to 3 grams twice daily.Schedule of Methyl sulfonyl methaneN/AStorage Requirements for Methyl sulfonyl methaneN/AEffects of Missed Dosage of Methyl sulfonyl methaneIf a dose is missed, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.Effects of Overdose of Methyl sulfonyl methaneIf over dosage is suspected,contact immediate medical attention.Minerals
About MineralsDietary mineral supplement, Nutritional supplement.Mechanism of Action of MineralsN/APharmacokinets of MineralsN/AOnset of Action for MineralsN/ADuration of Action for MineralsN/AHalf Life of MineralsN/ASide Effects of MineralsN/AContra-indications of MineralsN/ASpecial Precautions while taking MineralsN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for MineralsN/AInteractions for MineralsN/ATypical Dosage for MineralsN/ASchedule of MineralsN/AStorage Requirements for MineralsN/AEffects of Missed Dosage of MineralsN/AEffects of Overdose of MineralsN/AHome Delivery for Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals and other medicines and health products. Home delivery services for glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals before they complete the sale. You can get this information while placing the order for glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals with the pharmacy.
Glucosamine + Chondroitin Sulphate + Vitamin C + Vitamin D3 + Vitamin E + Methyl sulfonyl methane + Minerals is a generic medicine name and there are several brands available for it. Some of the brands for glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals might be better known than glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals itself. If the pharmacy that's willing to deliver medicines to your home doesn't have glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals in stock, you can ask for one of the branded alternatives for glucosamine + chondroitin sulphate + vitamin c + vitamin d3 + vitamin e + methyl sulfonyl methane + minerals.