- Medicine India
- Generic Medicines
- D
- Pharmacology For Diclofenac Potassium + Paracetamol + Chlorzoxazone + Famotidine
Diclofenac Potassium + Paracetamol + Chlorzoxazone + Famotidine Pharmacology
Diclofenac Potassium + Paracetamol + Chlorzoxazone + Famotidine
About Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/AMechanism of Action of Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/APharmacokinets of Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/AOnset of Action for Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/ADuration of Action for Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/AHalf Life of Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/ASide Effects of Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/AContra-indications of Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/ASpecial Precautions while taking Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/AInteractions for Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/ATypical Dosage for Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/ASchedule of Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/AStorage Requirements for Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/AEffects of Missed Dosage of Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/AEffects of Overdose of Diclofenac Potassium + Paracetamol + Chlorzoxazone + FamotidineN/ADiclofenac Potassium
About Diclofenac PotassiumNSAID, anti-inflammatory ,antipyretic and analgesic.Mechanism of Action of Diclofenac PotassiumDiclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.Pharmacokinets of Diclofenac PotassiumAbsorption: Diclofenac potassium is rapidly absorbed after oral administration. It undergoes first pass metabolism. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac potassium is metabolised in the liver to mainly 4 hydroxy Diclofenac. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.Onset of Action for Diclofenac PotassiumAnalgesic action: with in 60 minutes and Antirheumatic action with in 2 weeksDuration of Action for Diclofenac Potassium12hoursHalf Life of Diclofenac Potassium1-2 hoursSide Effects of Diclofenac Potassium1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Flatulence
9.Ulceration of the stomach or intestine
10.Dyspepsia
11.Headache
12.Dizziness
13.Rash
Contra-indications of Diclofenac Potassium1.Hypersensitivity to Diclofenac and other Non steroidal anti inflammatory drugs(((NSAID)))
2.Peptic ulcer
3.Asthma
Special Precautions while taking Diclofenac Potassium1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Blood clotting disorders
5.Gastrointestinal diseases
6.Proctitis
7.Asthma
8.Cautioned against driving, operating or activities requiring concentration
9.Avoid alcohol
10.Heart failure
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
CHILDREN below 14: contraindicatedIndications for Diclofenac Potassium1.Rheumatoid arthritis
2.Ankylosing spondylitis
3.Acute gout
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
5.Osteoarthritis
6.For the relief of pain and inflammation in dental minor surgery and orthopedic
7.Dysmenorrhoea
8.Migraine
Interactions for Diclofenac PotassiumN/ATypical Dosage for Diclofenac PotassiumAdult: 100 - 150 mg / day in 2 - 3 divided doses.
For the relief of pain, Migraine, Dysmenorrhoea: 150 mg / day in 3 divided doses.
Osteoarthritis: 50 mg 2 - 3 times daily
Rheumatoid arthritis: 150 - 200 mg / day in 3 - 4 divided doses.
Schedule of Diclofenac PotassiumHStorage Requirements for Diclofenac PotassiumStore Diclofenac potassium at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of Diclofenac PotassiumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Diclofenac PotassiumGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.Paracetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Chlorzoxazone
About ChlorzoxazoneA benzoxazolone derivative, Centrally acting Muscle relaxant and mild sedative.Mechanism of Action of ChlorzoxazoneThis muscle relaxant works by blocking nerve impulses (or pain sensations) that are sent to your brain. It inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. It may also reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium influx.Pharmacokinets of ChlorzoxazoneAbsorption- Rapidly and completely absorbed after oral administration.
Distribution- Widely distributed in the body.
Metabolism- It is metabolized in the liver to its metabolites by glucoronide conjugation.
Excretion- It is excreted through urine.
Onset of Action for Chlorzoxazone1 hr after oral administrationDuration of Action for Chlorzoxazone3 to 4 hrsHalf Life of ChlorzoxazoneN/ASide Effects of Chlorzoxazone1. Difficulty breathing
2. Closing of your throat
3. Swelling of your lips, tongue, or face
4. Liver damage
5. Yellowing of the skin or eyes
5. Nausea
6. Abdominal pain or discomfort
7. Unusual bleeding or bruising
8. Severe fatigue
9. Stomach damage
10. Drowsiness
11. Dizziness
12. Lightheadedness
13. Discolored urine
14. Rash
Contra-indications of Chlorzoxazone1. Hypersensitivity to the drugSpecial Precautions while taking Chlorzoxazone1. Liver problems
2. Stomach problems
3. Intestinal problems
4. Any drug allergies
5. Any work which require mental alertness such as driving and machines operating
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Chlorzoxazone1. Painful skeletal muscle spasmsInteractions for ChlorzoxazoneAlcohol or other CNS depressants: Additive effect if used concomitantly.Typical Dosage for ChlorzoxazoneAdults: 250 mg-750 mg 3-4 times daily.
Children: 125 mg -500 mg 3-4 times daily.
Schedule of ChlorzoxazoneHStorage Requirements for ChlorzoxazoneStore at room temperature away from moisture and heat.Effects of Missed Dosage of ChlorzoxazoneTake the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.Effects of Overdose of ChlorzoxazoneGive symptomatic and supportive treatment. Induce emesis or gastric lavage. Administer activated charcoal to avoid further absorption of drug.Famotidine
About FamotidineGuanidine:Thiazole derivative,a histamine H2-receptor antagonist, Anti-secretory,Antiulcer.Mechanism of Action of FamotidineFamotidine is a H2 (Histamine) receptor antagonist. Histamine is the most potent stimulus of acid secretion and acts as the common mediator. H2 receptor is a G-protein coupled receptor. It induces adenylate cyclase which converts ATP to cyclic AMP. This cyclic AMP acts on proton pump and exchange extracellular potassium ion for intracellular hydrogen ion across the parietal cell membrane. Famotidine reversibly competes with Histamine for binding to H2 receptors on the parietal cells and predominantly inhibits basal acid secretion.
Anaesthetic adjuncts: It is used in patients undergoing prolonged operations, caesarian section; obese patients are at increased risk of gastric regurgitation and aspiration pneumonia. It raises pH of gastric juice and also reduces its volume and thus chances of regurgitation. It is now routinely used before prolonged surgery.
Pharmacokinets of FamotidineAbsorption: Famotidine is 40 - 45 % absorbed after oral administration. Distribution: Distributed mainly in unbound form. Metabolism: Famotidine undergoes metabolism in the liver. Excretion: It is excreted mainly in urine and in the faeces.Onset of Action for Famotidine60 minutesDuration of Action for Famotidine2.5-3.5 hoursHalf Life of Famotidine2.5 - 3.5 hoursSide Effects of Famotidine1.Headache
2.Dizziness
3.Constipation
4.Diarrhoea
5.Nausea
6.Vertigo
7.Confusion
8.Rash
9.Thrombocytopenia
10.Leukopenia
Contra-indications of Famotidine1. Hypersensitivity to FamotidineSpecial Precautions while taking Famotidine1.Hepatic impairment
2.Renal impairment
3.Acute Porphyria
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution.
NEONATES: contraindicatedIndications for Famotidine1.Duodenal ulcer
2.Benign gastric ulcer
3.Zollinger- Ellison syndrome
4.Gastroesophageal reflux diseases
5.Acid indigestion
6.Heart burn
7.Sour stomach
8.Preanaesthetic medication (PAM)
Interactions for FamotidineAntacids: Bioavailability of Famotidine slightly decreased, hence antacids in small doses can be given concomitantly.Typical Dosage for FamotidineAdult: 40mg / day
Duodenal ulcer, benign gastric ulcer: 40 mg /day as single dose at bed time or in 2 divided dose (morning and bed time) for 1 - 2 months. Maintenance dose: 20 mg / day at bed time.
Zollinger- Ellison syndrome: 80mg / day in 4 divided doses; dose can be increased if necessary to a maximum up to 800 mg / day
Gastroesophageal reflux disease: 40 mg / day as single dose at bed time or in 2 divided doses (morning and bed time) for maximum 2-3 months, dose can be increased to 80 mg / day in 2 divided doses if needed.
Acid indigestion, Heart burn, Sour stomach: Dose: 20mg/day in 2 divided doses.
PAM: 20mg given night before and in the morning before surgical procedure.
Schedule of FamotidineHStorage Requirements for FamotidineStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of FamotidineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FamotidineGive supportive measures and symptomatic treatment. Drug can be removed from the body by inducing emesis and or by gastric lavage. Activated charcoal is given to reduce the absorption of the drug. Haemodialysis can be done if necessary.Home Delivery for Diclofenac Potassium + Paracetamol + Chlorzoxazone + Famotidine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including diclofenac potassium + paracetamol + chlorzoxazone + famotidine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for diclofenac potassium + paracetamol + chlorzoxazone + famotidine and other medicines and health products. Home delivery services for diclofenac potassium + paracetamol + chlorzoxazone + famotidine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take diclofenac potassium + paracetamol + chlorzoxazone + famotidine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for diclofenac potassium + paracetamol + chlorzoxazone + famotidine before they complete the sale. You can get this information while placing the order for diclofenac potassium + paracetamol + chlorzoxazone + famotidine with the pharmacy.
Diclofenac Potassium + Paracetamol + Chlorzoxazone + Famotidine is a generic medicine name and there are several brands available for it. Some of the brands for diclofenac potassium + paracetamol + chlorzoxazone + famotidine might be better known than diclofenac potassium + paracetamol + chlorzoxazone + famotidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have diclofenac potassium + paracetamol + chlorzoxazone + famotidine in stock, you can ask for one of the branded alternatives for diclofenac potassium + paracetamol + chlorzoxazone + famotidine.