Risedronate Pharmacology

Risedronate

About Risedronate
Bisphosphonate Derivative, Bone resorption inhibitor,in osteoporosis.
Mechanism of Action of Risedronate
This bisphosphonate is an analogue of pyrophosphate in which the P-O-P bond is replaced by a non hydrolysable P-C-P bond. With divalent cation such as Ca2+ (calcium ion) in the bone they can capable to form chelating complex and form a three dimensional structure. It has high affinity for active remodeling site in the bone. Bisphosphonate retard formation and dissolution of hydroxy apatite crystals within bone and other site. Bisphosphonate remain in the matrix until the bone is remolded and then released in the acid environment of the resorption lacunae beneath the osteoclasts as the overlying mineral matrix is dissolved. It produces antiresorptive action by osteoclasts apoptosis activity and by inhibition of components of the cholesterol biosynthetic pathway.
Pharmacokinets of Risedronate
Absorption- Rapidly absorbed after oral administration.
Distribution- Widely distributed into the bones. ~24% bound to the plasma proteins.
Excretion- Excreted through urine and feces.
Onset of Action for Risedronate
N/A
Duration of Action for Risedronate
N/A
Half Life of Risedronate
N/A
Side Effects of Risedronate
1. Hives
2. Difficulty in breathing
3. Swelling of your face, lips, tongue, or throat
4. Chest pain
5. Difficulty or pain when swallowing
6. Pain or burning under the ribs or in the back
7. Worsening heartburn
8. Severe joint, bone, or muscle pain
9. Jaw pain
10. Numbness
11. Diarrhea
12. Gas
13. Constipation
14. Headache
Contra-indications of Risedronate
1. Hypersensitivity to the drug or any components of it
Special Precautions while taking Risedronate
1. Digestive system problems
2. Hypocalcaemia
3. Kidney problems
4. Do not lie down for at least 30 minutes after you take a Residronate tablet.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Risedronate
1. Paget`s disease of bone (osteitis deformans)
2. Osteoporosis
3. Glucocorticoid-induced osteoporosis

Interactions for Risedronate
N/A
Typical Dosage for Risedronate
Adults-
Oral-
For prevention and treatment of corticosteroid-induced osteoporosis:5 mg/day at least 30 minutes before the first food or drink of the day other than water.
For Paget`s disease of the bone: 30 mg/day for two months.
For prevention and treatment of postmenopausal osteoporosis: 5 mg/day or 35 mg/week at least 30 minutes before the first food or drink of the day other than water.
Schedule of Risedronate
N/A
Storage Requirements for Risedronate
Tablets should be stored at room temperature,15-30 ?C (59-86 ?F).
Effects of Missed Dosage of Risedronate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Risedronate
Give symptomatic and supportive treatment.

Home Delivery for Risedronate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including risedronate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for risedronate and other medicines and health products. Home delivery services for risedronate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take risedronate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for risedronate before they complete the sale. You can get this information while placing the order for risedronate with the pharmacy.

Risedronate is a generic medicine name and there are several brands available for it. Some of the brands for risedronate might be better known than risedronate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have risedronate in stock, you can ask for one of the branded alternatives for risedronate.