Oxybutynin Pharmacology

Oxybutynin

About Oxybutynin
Antimuscarinic agent, Urinary Antispasmodic Agent.
Mechanism of Action of Oxybutynin
This drug decreases muscle spasms of the bladder by competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. It also has direct spasmolytic effects on bladder smooth muscle as a calcium antagonist and local anesthetic action at high concentrations.
Pharmacokinets of Oxybutynin
Absorption- Rapidly and completely absorbed after oral administration.
Distribution- Widely distributed in the body. 91%-93% bound to the plasma proteins. It also distributed to the breast milk
Metabolism - 94% undergo first pass metabolism. It also undergo hepatic metabolism.
Excretion- Excreted through urine.
Onset of Action for Oxybutynin
N/A
Duration of Action for Oxybutynin
N/A
Half Life of Oxybutynin
N/A
Side Effects of Oxybutynin
1. Dry mouth
2. Sensitivity to bright light
3. Blurred vision
4. Dry eyes
5. Decreased sweating
6. Flushing
7. Upset stomach
8. Drowsiness
9. Fever
10. Fast pulse
11. Heart palpitations
12. Restlessness
13. Seizures
14. Difficulty urinating
15. Hallucinations (especially in children)


Contra-indications of Oxybutynin
1. Hypersensitivity to the drug or any ingredients of it
2. Blockage of the urinary tract (difficulty urinating)
3. Blockage in the intestines
4. Untreated angle closure glaucoma
5. Untreated narrow anterior chamber angles
6. Partial or complete obstruction of the gastrointestinal tract
7. Paralytic ileus
8. Intestinal atony of the elderly or debilitated patient
9. Megacolon
10. Complicating ulcerative colitis
11. Severe colitis
12. Myasthenia gravis.
13. Obstructive neuropathy
14. Unstable cardiovascular status in acute hemorrhage
Special Precautions while taking Oxybutynin
1. Take each oral dose with a full glass of water
2. Do not crush, chew, or break the extended release form of oxybutynin
Use with caution in patients with
1. Liver disease
2. Kidney disease
3. Numbness or tingling in the hands or feet
4. Difficulty swallowing solids or liquids
5. Reflux disease
6. Glaucoma
7. Myasthenia gravis
8. Ulcerative colitis
9. Thyroid problems
10. High blood pressure
11. Hiatal hernia
12. Enlargement of the prostate.
13. Any work which require mental alertness such as driving and machine operation


Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Oxybutynin
1. Urinary incontinence
2. Urgency and frequency in the unstable bladder
3. Nocturnal enuresis

Interactions for Oxybutynin
N/A
Typical Dosage for Oxybutynin
Oral-
For treatment of bladder problems:
Suspension:
Adults and children above12 years: 5 mg 2 or 3 times a day.
Children 5 to 12 years of age - 5 mg 2 or 3 times a day. The dose is usually not more than 15 mg a day.
Extended release tablets:
Adults and children above 12 years: 5 mg to 10 mg once daily.
Children (6 to 12 years of age) - 5 mg once daily. The dose is usually not more than 20 mg per day.
Schedule of Oxybutynin
N/A
Storage Requirements for Oxybutynin
Stored in a cool dark place. Protect from light and excessive heat.
Effects of Missed Dosage of Oxybutynin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Oxybutynin
Give symptomatic and supportive treatment.

Home Delivery for Oxybutynin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including oxybutynin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for oxybutynin and other medicines and health products. Home delivery services for oxybutynin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take oxybutynin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for oxybutynin before they complete the sale. You can get this information while placing the order for oxybutynin with the pharmacy.

Oxybutynin is a generic medicine name and there are several brands available for it. Some of the brands for oxybutynin might be better known than oxybutynin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have oxybutynin in stock, you can ask for one of the branded alternatives for oxybutynin.