Gatifloxacin (Eye Prep.) Pharmacology

Gatifloxacin (Eye Prep.)

About Gatifloxacin (Eye Prep.)
Fourth-generation fluoroquinolone, DNA Gyrase Inhibitor,Topoisomerase I Inhibitor, Ophthalmic Antibiotic.
Mechanism of Action of Gatifloxacin (Eye Prep.)
Gatifloxacin acts by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Gatifloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis in microorganism.
Pharmacokinets of Gatifloxacin (Eye Prep.)
Absorption: Absorption after ophthalmic application is minimal.
Onset of Action for Gatifloxacin (Eye Prep.)
N/A
Duration of Action for Gatifloxacin (Eye Prep.)
N/A
Half Life of Gatifloxacin (Eye Prep.)
N/A
Side Effects of Gatifloxacin (Eye Prep.)
1.Burning
2.Irritation
3.Itching
4.Bitter taste
5.Blurred vision
6.Increased sensitivity of the eyes to light
7.Redness
8.Swelling
9.Pain
10.Anaphylactic reactions
Contra-indications of Gatifloxacin (Eye Prep.)
1.Hypersensitivity to Gatifloxacin and other Fluoroquinolones
2.Not use injection or subconjunctivally in to the eye
Special Precautions while taking Gatifloxacin (Eye Prep.)
1.Prolonged use
2.If irritation occurs then discontinue the use of medicaments
3.Avoid contact lenses
4.Wear sun glasses if sensitivity to sunlight occurs
5.Avoid driving vehicle since it causes blurred vision
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Gatifloxacin (Eye Prep.)
1.Conjunctivitis
2.Corneal ulcers
3.Keratitis
4.Blepharitis
5.Dacrocystitis
6.Trachoma
7.Keratoconjunctivitis
8.Acute meibomianitis
9.Prophylaxis of ocular infections
Interactions for Gatifloxacin (Eye Prep.)
N/A
Typical Dosage for Gatifloxacin (Eye Prep.)
Gatifloxacin 0.3 %w/v drops is available.
Initial dose: Instill one drop every two hours in the affected eye while awake, up to 8 times daily for 2 days then instill one drop up to 4 times daily for next 5 days.
Eye ointment: Apply ? inch ribbon 3 times daily for 2 days and then reduce the dose to 2 times daily for next 5 days.
Schedule of Gatifloxacin (Eye Prep.)
N/A
Storage Requirements for Gatifloxacin (Eye Prep.)
Store at cool dry place. Protect from light. Do not freeze. Keep out of the reach of children. Avoid use of medicament 1 month after opening.
Effects of Missed Dosage of Gatifloxacin (Eye Prep.)
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Gatifloxacin (Eye Prep.)
Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes.

Home Delivery for Gatifloxacin (Eye Prep.) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including gatifloxacin (eye prep.).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for gatifloxacin (eye prep.) and other medicines and health products. Home delivery services for gatifloxacin (eye prep.) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take gatifloxacin (eye prep.) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for gatifloxacin (eye prep.) before they complete the sale. You can get this information while placing the order for gatifloxacin (eye prep.) with the pharmacy.

Gatifloxacin (Eye Prep.) is a generic medicine name and there are several brands available for it. Some of the brands for gatifloxacin (eye prep.) might be better known than gatifloxacin (eye prep.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have gatifloxacin (eye prep.) in stock, you can ask for one of the branded alternatives for gatifloxacin (eye prep.).