Mupirocin Pharmacology

Mupirocin

About Mupirocin
A naturally antibiotic isolated from Pseudomonas fluorescens, Antibiotic.
Mechanism of Action of Mupirocin
Mupirocin exerts its action by reversibly binding to isoleucyl transfer RNA synthetase and inhibits the enzyme activity. This enzyme is necessary for the synthesis of proteins in the bacteria. Inhibition of isoleucyl transfer RNA synthetase results in inhibition of protein synthesis and produce microbicidal action. It is more active against gram positive bacteria as compared to gram negative bacteria.
Pharmacokinets of Mupirocin
Absorption: Mupirocin is negligibly absorbed after topical administration.
Onset of Action for Mupirocin
N/A
Duration of Action for Mupirocin
N/A
Half Life of Mupirocin
N/A
Side Effects of Mupirocin
Topical use :
1. Irritation
2. Burning
3. Rashes
4. Pruritis
5. Stinging
6. Erythema
7. Dryness
8. Dermatitis
9. Pain
Nasal use:
1. Rhinitis
2. Cough
3. Headache
4. Pharyngitis
5. Change in taste
6. Chest congestion
Contra-indications of Mupirocin
1. Hypersensitivity to Mupirocin
Special Precautions while taking Mupirocin
1. If sensitivity occurs discard the use of the medicament
2. Renal impairment
3. Patient with burns
4. Avoid contact with eyes and mucous membrane
5. Avoid application in the large surface area(extensive wound)
6. Monitor for super infection
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Use with caution
Indications for Mupirocin
Bacterial skin infections:
1. Impetigo
2. Infected eczema
3. Folliculitis
4. Eradication of nasal colonization of Methicillin resistant S.aureus
Interactions for Mupirocin
N/A
Typical Dosage for Mupirocin
Adult:
Topical use: 2% cream, and ointment: Wash and dry the affected area thoroughly. Apply the medicament as a thin film over the affected part. Rub gently. Cover with a surgical gauze. Apply 3 times daily for 1 - 2 weeks.
Intranasal use: 2 % ointment: Apply the half of the content of a single use tube in to one nostril and other half in to other nostril. Press the sides of the nostrils together and release it. Repeat it for 1 minute. Apply it morning and evening.
Schedule of Mupirocin
N/A
Storage Requirements for Mupirocin
Store at room temperature in a tightly closed container. Keep away from moisture and heat. Keep out of the reach of children.
Effects of Missed Dosage of Mupirocin
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Mupirocin
Give supportive measures and symptomatic treatment.

Home Delivery for Mupirocin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mupirocin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mupirocin and other medicines and health products. Home delivery services for mupirocin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mupirocin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mupirocin before they complete the sale. You can get this information while placing the order for mupirocin with the pharmacy.

Mupirocin is a generic medicine name and there are several brands available for it. Some of the brands for mupirocin might be better known than mupirocin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mupirocin in stock, you can ask for one of the branded alternatives for mupirocin.