Zinc + Sulfadiazine Pharmacology

Zinc + Sulfadiazine

About Zinc + Sulfadiazine
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Mechanism of Action of Zinc + Sulfadiazine
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Pharmacokinets of Zinc + Sulfadiazine
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Onset of Action for Zinc + Sulfadiazine
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Duration of Action for Zinc + Sulfadiazine
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Half Life of Zinc + Sulfadiazine
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Side Effects of Zinc + Sulfadiazine
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Contra-indications of Zinc + Sulfadiazine
N/A
Special Precautions while taking Zinc + Sulfadiazine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Zinc + Sulfadiazine
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Interactions for Zinc + Sulfadiazine
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Typical Dosage for Zinc + Sulfadiazine
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Schedule of Zinc + Sulfadiazine
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Storage Requirements for Zinc + Sulfadiazine
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Effects of Missed Dosage of Zinc + Sulfadiazine
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Effects of Overdose of Zinc + Sulfadiazine
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Zinc

About Zinc
Trance metal, Dietary mineral, Nutritional supplement,Treatment of zinc deficiency,in wound healing.
Mechanism of Action of Zinc
Zinc acts as a cofactor for more than 70 different enzymes. Zinc dependent enzymes are involved in the metabolism of carbohydrates, lipids, and proteins. Zinc facilitates wound healing, normal growth rates, normal skin hydration and maintains senses of taste and smell. It provides normal growth and tissue repair. It also helps in development of cell mediated immunity.
Pharmacokinets of Zinc
Absorption: Poorly absorbed orally, Distribution: Zinc is distributed mainly in to skeletal muscle, skin, bone, pancreas, kidney, liver, retina, prostate, RBC, and WBC. Excretion: Excreted mainly through intestine; only 2% loss in the urine.
Onset of Action for Zinc
N/A
Duration of Action for Zinc
N/A
Half Life of Zinc
N/A
Side Effects of Zinc
1. Nausea
2. Vomiting
3. Abdominal distress
4. Gastric ulceration
5. Rashes
Contra-indications of Zinc
N/A
Special Precautions while taking Zinc
1.Don`t exceed prescribed dose
2.Renal failure
3.Biliary obstruction

Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Zinc
1. Zinc deficiency
2. Acne vulgaris
3. Chronic skin ulcers
4. Adjunct to antimicrobials
5. Delayed wound healing
6. Alopecia
Interactions for Zinc
Fluoroquinolones, Tetracyclines: Decreased GI absorption and serum levels of some fluoroquinolone.
Pencillamine: Reduced absorption of zinc.
Iron: Reduced absorption of iron and vice versa.

Typical Dosage for Zinc
Adults: 25 to 50mg zinc daily or 1 to 2 tablets daily.
Children: 5mg/kg 1 to 3 times daily.
Schedule of Zinc
N/A
Storage Requirements for Zinc
Store at a temperature below 30 degree C
Effects of Missed Dosage of Zinc
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Zinc
Provide symptomatic treatment and supportive measures

Sulfadiazine

About Sulfadiazine
Short acting sulfonamide, Antibiotic.
Mechanism of Action of Sulfadiazine
Sulfadiazine is a short-acting sulfonamide. Sulfadiazine is a structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of dihydrofolic acid, a compound that bacteria must be able to make in order to survive for the synthesis of folic acid, an important metabolite in DNA synthesis. It is usually given with Pyrimethamine in the treatment of Chloroquine resistant Plasmodium falciparum in a fixed dose formulation.
Sulfadiazine has also been used with other sulfonamides, particularly Sulfamerazine and Sulfadimidine, to reduce the problems of low solubility in urine.

Pharmacokinets of Sulfadiazine
Pharmaco Kinetic
Absorption: Sulfadiazine is readily absorbed from the gastrointestinal tract.
Distribution: About 20 - 55% of the drug is distributed in protein bound form.It penetrates into the CSF. Excretion: Drug and its metabolites are excreted in urine.
Onset of Action for Sulfadiazine
N/A
Duration of Action for Sulfadiazine
N/A
Half Life of Sulfadiazine
10 hours
Side Effects of Sulfadiazine
1.Loss of appetite
2.Diarrhoea.
3.Headache
4.Fatigue
5.Dizziness
6.Difficulty sleeping
7.Allergic reactions
Contra-indications of Sulfadiazine
N/A
Special Precautions while taking Sulfadiazine
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Sulfadiazine
1.Nocardiosis
2.Lymphogranuloma venereum
3.Rheumatic fever in penicillin-allergic patients
4.Toxoplasmosis
Interactions for Sulfadiazine
N/A
Typical Dosage for Sulfadiazine
Adult: Initial doses of 2 to 4 g, followed by up to 6 g daily in divided doses.
Children:
Initial dose: 75 mg/kg, then 150 mg/kg daily in divided doses to a maximum of 6 g daily. Infants less than 2 months:
Congenital toxoplasmosis: 50 mg/kg twice daily for 12 months
Toxoplasmosis (Immuno compromised patients): 4 to 6 g daily in 4 divided doses for at least 6 weeks, followed by 2 to 4 g daily
For the prophylaxis of rheumatic fever: 500mg - 1 g daily
Schedule of Sulfadiazine
N/A
Storage Requirements for Sulfadiazine
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light.
Effects of Missed Dosage of Sulfadiazine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Sulfadiazine
Give symptomatic and supportive treatment. Induce gastric lavage.

Home Delivery for Zinc + Sulfadiazine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including zinc + sulfadiazine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for zinc + sulfadiazine and other medicines and health products. Home delivery services for zinc + sulfadiazine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take zinc + sulfadiazine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for zinc + sulfadiazine before they complete the sale. You can get this information while placing the order for zinc + sulfadiazine with the pharmacy.

Zinc + Sulfadiazine is a generic medicine name and there are several brands available for it. Some of the brands for zinc + sulfadiazine might be better known than zinc + sulfadiazine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have zinc + sulfadiazine in stock, you can ask for one of the branded alternatives for zinc + sulfadiazine.