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- Pharmacology For Miconazole + Clobetasol propionate
Miconazole + Clobetasol propionate Pharmacology
Miconazole + Clobetasol propionate
About Miconazole + Clobetasol propionateN/AMechanism of Action of Miconazole + Clobetasol propionateN/APharmacokinets of Miconazole + Clobetasol propionateN/AOnset of Action for Miconazole + Clobetasol propionateN/ADuration of Action for Miconazole + Clobetasol propionateN/AHalf Life of Miconazole + Clobetasol propionateN/ASide Effects of Miconazole + Clobetasol propionateN/AContra-indications of Miconazole + Clobetasol propionateN/ASpecial Precautions while taking Miconazole + Clobetasol propionateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Miconazole + Clobetasol propionateN/AInteractions for Miconazole + Clobetasol propionateN/ATypical Dosage for Miconazole + Clobetasol propionateN/ASchedule of Miconazole + Clobetasol propionateN/AStorage Requirements for Miconazole + Clobetasol propionateN/AEffects of Missed Dosage of Miconazole + Clobetasol propionateN/AEffects of Overdose of Miconazole + Clobetasol propionateN/AMiconazole
About MiconazoleAn imidazole derivative, Broad spectrum Antifungal.Mechanism of Action of MiconazoleMiconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesisPharmacokinets of MiconazoleAbsorption: Oral absorption of Miconazole is poor. Distribution: It is distributed in the body in protein bound form Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted in urine and faeces.Onset of Action for MiconazoleN/ADuration of Action for MiconazoleN/AHalf Life of Miconazole1 daySide Effects of Miconazole1.Vulvovaginal burning
2.Burning
3.Irritation
4.Pruritis
5.Maceration
6.Dermatitis Contra-indications of Miconazole1.Hypersensitivity to Miconazole and other Azole antifungalsSpecial Precautions while taking Miconazole1.Hepatic dysfunctionPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: contraindicated
Indications for Miconazole1.Tinea versicolor
2.Vulvovaginal candidiasis
3.Tinea pedis
4.Tinea corporis
5.Tinea cruris
6.Otomycosis
7.Onychomycosis
8.Oral candidiasis
9.Intestinal candidiasis
10.Diaper dermatitisInteractions for MiconazoleBenzoyl peroxide: Antibacterial synergism. Typical Dosage for MiconazoleAdult: Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea versicolor: Apply the cream once daily on the affected part
Vaginal use: Insert 300 mg suppository at bed time for 3 days or Insert 100 mg suppository at bed time for 7 days
CHILDREN:
Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea vericolor: Apply the cream once daily on the affected part
Schedule of MiconazoleHStorage Requirements for MiconazoleThe drug should be stored at 15 - 30 degree C.Effects of Missed Dosage of MiconazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MiconazoleGive supportive measures and treatment.
Clobetasol propionate
About Clobetasol propionateTopical adenocorticoid, Anti inflammatory.Mechanism of Action of Clobetasol propionateClobetasol is a topical corticosteroid. It induces peptide Lipocortins which inhibit the enzyme Phospholipase A2. Phospholipase A2 is essential for the conversion of membrane phospholipids to Arachidonic acid. From this Arachidonic acid inflammatory mediators like prostaglandins, kinins, histamine, liposomal enzymes and the complement system are produced. By inhibiting Phospholipase A2 inflammatory mediators are not released. It also inhibits the migration of macrophages and leukocytes to the inflamed area by its vasoconstrictive properties. Corticosteroids also inhibit capillary production, collagen deposition and keloid (scar) formation. Thus inhibiting inflammatory mediators and other actions Clobetasol are used for anti-inflammatory conditions.Pharmacokinets of Clobetasol propionateAbsorption: Clobetasol is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, amount of drug applied and the epidermal barrier (nature of skin)Onset of Action for Clobetasol propionateN/ADuration of Action for Clobetasol propionateN/AHalf Life of Clobetasol propionateN/ASide Effects of Clobetasol propionate1.Thinning of epidermis
2.Burning
3. Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8.Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
Contra-indications of Clobetasol propionate1.Hypersensitivity to Clobetasol and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5.Tuberculosis infection of the skin
6.Viral,fungal or bacterial primary infections
7.Ulcers
Special Precautions while taking Clobetasol propionate1.Avoid application on large surface area
2.Prolonged use
3.Psoriasis
4.Avoid contact with eyes,mouth and mucous membrane
5.Avoid occlusive dressing or plastic damage
6.Not used more than 5 days on the face or in the children
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below12 years: ContraindicatedIndications for Clobetasol propionate1.Skin disorders
2.Eczema
3.Psoriasis
4.Alopecia areata
5.Inflammation of corticosteroid dermatoses (secondary infected)
6.Chronic discoid lupus Erythematosus
Interactions for Clobetasol propionateN/ATypical Dosage for Clobetasol propionateTopical: Clobetasol 0.05 % cream and gel are available. Medicament is applied thinly and evenly on the affected area. 2 times a day, maximum 2 weeks. Maximum dose: 50 g of the cream/ week. Schedule of Clobetasol propionateHStorage Requirements for Clobetasol propionateStore at room temperature. Protect from heat, moisture and light. Keep out of the reach of childrenEffects of Missed Dosage of Clobetasol propionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Clobetasol propionateGive supportive measures and symptomatic treatment.Home Delivery for Miconazole + Clobetasol propionate in Your City
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