Ciclopiroxolamine + Fluocinolone acetonide Pharmacology

Ciclopiroxolamine + Fluocinolone acetonide

About Ciclopiroxolamine + Fluocinolone acetonide
N/A
Mechanism of Action of Ciclopiroxolamine + Fluocinolone acetonide
N/A
Pharmacokinets of Ciclopiroxolamine + Fluocinolone acetonide
N/A
Onset of Action for Ciclopiroxolamine + Fluocinolone acetonide
N/A
Duration of Action for Ciclopiroxolamine + Fluocinolone acetonide
N/A
Half Life of Ciclopiroxolamine + Fluocinolone acetonide
N/A
Side Effects of Ciclopiroxolamine + Fluocinolone acetonide
N/A
Contra-indications of Ciclopiroxolamine + Fluocinolone acetonide
N/A
Special Precautions while taking Ciclopiroxolamine + Fluocinolone acetonide
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Ciclopiroxolamine + Fluocinolone acetonide
N/A
Interactions for Ciclopiroxolamine + Fluocinolone acetonide
N/A
Typical Dosage for Ciclopiroxolamine + Fluocinolone acetonide
N/A
Schedule of Ciclopiroxolamine + Fluocinolone acetonide
N/A
Storage Requirements for Ciclopiroxolamine + Fluocinolone acetonide
N/A
Effects of Missed Dosage of Ciclopiroxolamine + Fluocinolone acetonide
N/A
Effects of Overdose of Ciclopiroxolamine + Fluocinolone acetonide
N/A

Ciclopiroxolamine

About Ciclopiroxolamine
A synthetic antifungal agent, a hydroxypyridone derivaive.Topical Antifungal Agent.
Mechanism of Action of Ciclopiroxolamine
Ciclopiroxolamine is a chelating agent. It forms complexes with polyvalent metal cations eg.Fe3+, Al 3+. These metal cations are essential for enzymes for exerting their cellular activities including mitochondrial electron transport and energy production. Ciclopirox alters plasma membrane of fungi and changes the internal structure of fungus. It also possesses anti-inflammatory action by inhibiting lipoxygenase and cyclo-oxygenase enzymes.
Pharmacokinets of Ciclopiroxolamine
Absorption: Absorption of the medicament is minimal after topical application.
Onset of Action for Ciclopiroxolamine
N/A
Duration of Action for Ciclopiroxolamine
N/A
Half Life of Ciclopiroxolamine
1.7 hours for 1% topical solutions
Side Effects of Ciclopiroxolamine
1.Burning
2.Irritation
3.Itching
4.Redness
5.Rashes
6.Dryness
7.Pruritis
Contra-indications of Ciclopiroxolamine
1.Hypersensitivity to Ciclopiroxolamine
Special Precautions while taking Ciclopiroxolamine
1. Avoid the use of medicaments if irritation occurs
2. Avoid contact with eyes, mucus membrane and mouth
3. For external use only
4. Avoid use of occlusive dressings
Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Ciclopiroxolamine
1.Cutaneous candidiasis
2.Dermatophytosis
3.Pityriasis versicolor
4.Vulvovaginal candidiasis
Interactions for Ciclopiroxolamine
No known interaction.
Typical Dosage for Ciclopiroxolamine
Topical: Ciclopiroxolamine 1% cream. Solution and powder are used. Clean and dry the affected and surrounded area. Apply the medicament with gentle massage over the area twice daily for 1 month
:
Schedule of Ciclopiroxolamine
N/A
Storage Requirements for Ciclopiroxolamine
Store at room temperature. Keep away from moisture and heat. Keep out of the reach of children
Effects of Missed Dosage of Ciclopiroxolamine
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ciclopiroxolamine
Give supportive measures and symptomatic treatment.

Fluocinolone acetonide

About Fluocinolone acetonide
A synthetic hydrocortisone derivative, Vasoprotective ,reduce skin inflammation.
Mechanism of Action of Fluocinolone acetonide
Fluocinolone is a topical high potency glucocorticoid.
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-?, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Fluocinolone also has immunosuppressant and antimitotic actions.
Pharmacokinets of Fluocinolone acetonide
Absorption: Fluocinolone is absorbed( <1 %) through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, area of skin and the epidermal barrier.
Onset of Action for Fluocinolone acetonide
N/A
Duration of Action for Fluocinolone acetonide
N/A
Half Life of Fluocinolone acetonide
N/A
Side Effects of Fluocinolone acetonide
1.Thinning of epidermis
2.Burning
3. Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8. Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Stinging
12.Cataract,Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
13. Hypertrichosis
14. Dryness
15. Acne
Contra-indications of Fluocinolone acetonide
1. Hypersensitivity to Fluocinolone and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5. Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.Ulcers
Special Precautions while taking Fluocinolone acetonide
1.Avoid application on large surface area
2. Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5. Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children
7. If irritation or hypersensitivity occurs avoid the use of medicaments.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Fluocinolone acetonide
1.Psoriasis
2.Eczema
3.Otitis externa
4.Lichen simplex and planus
5.Anal and vulval pruritis
6.Contact dermatitis
7.Seborrheic dermatitis
8. Dermatoses (secondary infected)
Interactions for Fluocinolone acetonide
N/A
Typical Dosage for Fluocinolone acetonide
Topical: Fluocinolone 0.0025 %, 0.01% cream, ointment, gel or lotion is used. Clean and dry the affected area and apply the medicament thinly and evenly on the affected area for 2 - 3 times daily for 2 weeks.
Schedule of Fluocinolone acetonide
N/A
Storage Requirements for Fluocinolone acetonide
Store at room temperature. Protect from heat and moisture. Keep out of the reach of children
Effects of Missed Dosage of Fluocinolone acetonide
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Fluocinolone acetonide
Give supportive measures and symptomatic treatment.

Home Delivery for Ciclopiroxolamine + Fluocinolone acetonide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ciclopiroxolamine + fluocinolone acetonide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ciclopiroxolamine + fluocinolone acetonide and other medicines and health products. Home delivery services for ciclopiroxolamine + fluocinolone acetonide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ciclopiroxolamine + fluocinolone acetonide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ciclopiroxolamine + fluocinolone acetonide before they complete the sale. You can get this information while placing the order for ciclopiroxolamine + fluocinolone acetonide with the pharmacy.

Ciclopiroxolamine + Fluocinolone acetonide is a generic medicine name and there are several brands available for it. Some of the brands for ciclopiroxolamine + fluocinolone acetonide might be better known than ciclopiroxolamine + fluocinolone acetonide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ciclopiroxolamine + fluocinolone acetonide in stock, you can ask for one of the branded alternatives for ciclopiroxolamine + fluocinolone acetonide.