Idarubicin Pharmacology

Idarubicin

About Idarubicin
An anthracycline derivative, antitumor antibiotic, Antineoplastic.
Mechanism of Action of Idarubicin
This anthracycline analogue of daunorubicin intercalates the DNA pairs. This drug inhibits the activity of enzyme topoisomerase 2 resulting in double and single stranded DNA breaks. By stabilizing the DNA-topoisomerase 2 complex, it prevent the relegation portion of the ligation-religation reaction that catalyses topoisomerase 2 . It has higher penetrating and intercalating capacity than daunorubicin.
Pharmacokinets of Idarubicin
Absorption-Rapidly absorbed after intravenous administration
Distribution- Widely distributed in the body.97% bound to the plasma proteins. It enters to the cerebrospinal fluid.
Metabolism - Extra hepatic and hepatic metabolism takes place.Idarubicinol is its active metabolite. Excretion - Excreted primarily through bile and a small amount through urine.
Onset of Action for Idarubicin
N/A
Duration of Action for Idarubicin
N/A
Half Life of Idarubicin
22 hrs
Side Effects of Idarubicin
1. Nausea
2. Vomiting
3. Lowered resistance to infection
4. Bruising or unusual bleeding
5. Anemia
6. Weakness
7. Sore in mouth
8. Taste changes
9. Diarrhea
10. Loss of appetite
11. Visual changes
12. Black, tarry stools
13. Blood in urine or in stool
14. Cough or hoarseness
15. Fever
16. Chills
17. Lower back or side pain
18. Painful or difficult urination
19. Pinpoint red spot on skin
20. Slurred speech
21. Swelling on leg or lower leg
22. Shortness of breath
23. Pulmonary fibrosis
24. Hepatotoxicity
25. Alopecia
26. Seizures
27. Myocardial infarction
28. Arrhythmia
29. Myelosuppression
30. Urticaria
Contra-indications of Idarubicin
1. Hypersensitivity to the drug
2. Recent immunization
Special Precautions while taking Idarubicin
1. Kidney disease
2. Liver disease
3. Cardiac disease
4. Bone marrow depression
5. Recent radiation therapy or chemotherapy
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Idarubicin
1. Breast cancer
2. Lung cancer
3. Lymphomas
4. Acute myelocytic leukemia
5. Other types of leukemia
6. Hormone-refractory prostate cancer
7. Non Hodgkins lymphomas disease
Interactions for Idarubicin
N/A
Typical Dosage for Idarubicin
Intravenous-
Adult-
12mg/metre square daily for 3 days
8mg/metre square daily for 5 days
Children-
8 to 10 mg/metre square daily for 3 days
Schedule of Idarubicin
N/A
Storage Requirements for Idarubicin
Stored at temperature between 15 to 30 degree Celsius. Protect from light
Effects of Missed Dosage of Idarubicin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Idarubicin
Give symptomatic and supportive treatment

Home Delivery for Idarubicin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including idarubicin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for idarubicin and other medicines and health products. Home delivery services for idarubicin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take idarubicin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for idarubicin before they complete the sale. You can get this information while placing the order for idarubicin with the pharmacy.

Idarubicin is a generic medicine name and there are several brands available for it. Some of the brands for idarubicin might be better known than idarubicin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have idarubicin in stock, you can ask for one of the branded alternatives for idarubicin.