Cyproheptadine + Peptone + Lysine Pharmacology

Cyproheptadine + Peptone + Lysine

About Cyproheptadine + Peptone + Lysine
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Mechanism of Action of Cyproheptadine + Peptone + Lysine
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Pharmacokinets of Cyproheptadine + Peptone + Lysine
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Onset of Action for Cyproheptadine + Peptone + Lysine
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Duration of Action for Cyproheptadine + Peptone + Lysine
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Half Life of Cyproheptadine + Peptone + Lysine
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Side Effects of Cyproheptadine + Peptone + Lysine
N/A
Contra-indications of Cyproheptadine + Peptone + Lysine
N/A
Special Precautions while taking Cyproheptadine + Peptone + Lysine
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated. Cyproheptadine is contraindicated in breast feeding mother so the combination generic is contraindicated
Children Related Information
N/A
Indications for Cyproheptadine + Peptone + Lysine
Cyproheptadine is a potent sedative, antihistamine and antiserotonin drug.Peptone and lysine are dietary aminiacids. This combination drug is used to increase appetite and thus growth.
1.Appette enhancer
Interactions for Cyproheptadine + Peptone + Lysine
N/A
Typical Dosage for Cyproheptadine + Peptone + Lysine
Children: 2.5 ml to be taken 2 times daily, for 6 months.
Schedule of Cyproheptadine + Peptone + Lysine
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Storage Requirements for Cyproheptadine + Peptone + Lysine
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Effects of Missed Dosage of Cyproheptadine + Peptone + Lysine
N/A
Effects of Overdose of Cyproheptadine + Peptone + Lysine
N/A

Cyproheptadine

About Cyproheptadine
Piperidine (nonselective) First Generation H1 Antagonist ,anticholinergic and antiserotonergic(5-HT2 receptor antagonist), antihistaminic,appetite stimulant.
Mechanism of Action of Cyproheptadine
Cyproheptadine is a sedative antihistamine with serotonin antagonist, and calcium-channel blocking actions. It competes with Histamine for H1 receptors present in the smooth muscle of gastrointestinal tract, bronchi, large blood vessels and uterus. Histamine cannot bind with H1 receptors and cannot produce histamine induced allergic symptoms. Cyproheptadine blocks serotonin receptors preferentially block 5HT2A receptor and are useful in migraine prophylaxis. It has weak anticholinergic activity and possesses mild CNS depressant properties. It also blocks voltage sensitive calcium channel in islet of pancreas and smooth muscle. Cyproheptadine increases appetite and cause weight gain.
Pharmacokinets of Cyproheptadine
Absorption: Cyproheptadine is well absorbed after oral administration. Distribution: It is distributed in the body in highly protein bound form. Metabolism: It is extensively metabolised in the liver. Excretion: Metabolites are excreted primarily in the urine; unchanged drug and small amount of metabolites are excreted through faeces.
Onset of Action for Cyproheptadine
15 - 60 minutes
Duration of Action for Cyproheptadine
N/A
Half Life of Cyproheptadine
1 - 4 hours
Side Effects of Cyproheptadine
1.Dizziness
2.Drowsiness
3.Fatigue
4.Nervousness
5.Sleepiness
6.Epigastric distress
7.Dry mouth
8.Nausea
9.Vomiting
10.Rash
11.Urine retention
12.Weight gain


Contra-indications of Cyproheptadine
1.Hypersensitivity to Cyproheptadine and other drugs of similar structure
2.Angle closure glaucoma
3.Acute asthma
4.Peptic ulcer
5.Bladder neck obstruction
6.Prostatic hyperplasia
7.Pyloroduodenal obstruction
8.Debilitated patients
9.Patient on monoamine oxidase inhibitory therapy.
Special Precautions while taking Cyproheptadine
1.Hypertension
2.Hyperthyroidism
3.Increased intraocular pressure
4.Bronchial asthma
5.Patient should be cautioned against activities requiring mental alertness such as driving, operating machine or involving in any hazardous activities 6.Avoid alcohol


Pregnancy Related Information
Use with caution
Old Age Related Information
Contraindicated.
Breast Feeding Related Information
Contraindicated.
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Cyproheptadine
1.Antiallergic
2.Appetite stimulant
3.Cluster headache
Interactions for Cyproheptadine
Alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, anti-anxiety drugs, narcotic analgesics): CNS depressant action potentiated.
MAOIs, tricylic antidepressants and atropine: Antimuscarinic action potentiated.
Aminoglycosides: Ototoxicity produced by aminoglycosides masked.

Typical Dosage for Cyproheptadine
Adult: 12 - 16 mg / day in 3 - 4 divided doses.
Maximum dose: 32 mg / day
Migraine prophylaxis and vascular headaches: Initial dose: 4 mg and may be repeated after 30 minutes; A maintenance dose of 4 mg may be given every 4 to 6 hours.

Children above 6 years: 8 - 12 mg / day in 2 - 3 divided doses
Maximum dose: 16 mg / day
Children 2 - 6: 4 - 6 mg / day in 2 - 3 divided doses
Maximum dose: 12 mg / day
Schedule of Cyproheptadine
G
Storage Requirements for Cyproheptadine
Store at room temperature in a tightly closed container.
Effects of Missed Dosage of Cyproheptadine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Cyproheptadine
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing vomiting. Absorption of the drug can be reduced by administration of activated charcoal. Hypotension can be treated by vasopressors and seizure with Diazepam or Phenytoin.

Peptone

About Peptone
Water-soluble protein derivative, Dietary amino acid.
Mechanism of Action of Peptone
N/A
Pharmacokinets of Peptone
N/A
Onset of Action for Peptone
N/A
Duration of Action for Peptone
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Half Life of Peptone
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Side Effects of Peptone
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Contra-indications of Peptone
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Special Precautions while taking Peptone
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
N/A
Children Related Information
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Indications for Peptone
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Interactions for Peptone
N/A
Typical Dosage for Peptone
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Schedule of Peptone
N/A
Storage Requirements for Peptone
N/A
Effects of Missed Dosage of Peptone
N/A
Effects of Overdose of Peptone
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Lysine

About Lysine
Nutrient, an a-amino acid, Essential amino acid.
Mechanism of Action of Lysine
Lysine is an essential amino acid. It is a basic building block of protein. It is required for tissue repair, growth and bone development in children, help in calcium absorption and maintaining the correct nitrogen balance in the body and maintaining lean body mass. It produces antibodies, hormones, enzymes, collagen formation.
Since it helps with the building of muscle protein, it is useful for patients recovering from injuries and recovery after operations. It is also useful against herpes and cold sores.
The single supplement should be taken on an empty stomach because larger amounts of the amino acid can build up in the blood and brain.
Pharmacokinets of Lysine
N/A
Onset of Action for Lysine
N/A
Duration of Action for Lysine
N/A
Half Life of Lysine
N/A
Side Effects of Lysine
1.Diarrhea
2.Stomach cramps
Contra-indications of Lysine
Hypersensitivity to the drug
Special Precautions while taking Lysine
1.Liver impairment
2.Kidney problems
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Lysine
1.Development and maintenance
2.Calcium absorption
3.Cold sores
Interactions for Lysine
N/A
Typical Dosage for Lysine
12 mg/ kg/ day.
For calcium absorption: 800 mg/day
For cold sores: 1000 mg/day if needed treatment can be continued up to 6 months
Schedule of Lysine
N/A
Storage Requirements for Lysine
Store at room temperature in a cool dry and dark area.Keep out of the reach of children.
Effects of Missed Dosage of Lysine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Lysine
Give supportive measures and symptomatic treatment

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