Ceftazidime +Tazobactam Pharmacology

Ceftazidime +Tazobactam

About Ceftazidime +Tazobactam

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Mechanism of Action of Ceftazidime +Tazobactam

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Pharmacokinets of Ceftazidime +Tazobactam

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Onset of Action for Ceftazidime +Tazobactam

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Duration of Action for Ceftazidime +Tazobactam

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Half Life of Ceftazidime +Tazobactam

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Side Effects of Ceftazidime +Tazobactam

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Contra-indications of Ceftazidime +Tazobactam

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Special Precautions while taking Ceftazidime +Tazobactam

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Pregnancy Related Information

Use with caution

Old Age Related Information

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Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution

Indications for Ceftazidime +Tazobactam

1.Infections caused by Gram Negative organisms like Enterobacter, Klebsiella and Proteus
2.Pseudomonal lung infections in patients with cystic fibrosis
3.Penicillinase producing bacterial infections

Interactions for Ceftazidime +Tazobactam

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Typical Dosage for Ceftazidime +Tazobactam

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Schedule of Ceftazidime +Tazobactam

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Storage Requirements for Ceftazidime +Tazobactam

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Effects of Missed Dosage of Ceftazidime +Tazobactam

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Effects of Overdose of Ceftazidime +Tazobactam

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Ceftazidime

About Ceftazidime

Third Generation Cephalosporin antibiotic, Parenteral antibiotic.

Mechanism of Action of Ceftazidime

Ceftazidime is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Ceftazidime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Ceftazidime.It is more active against pseudomonas.

Pharmacokinets of Ceftazidime

Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: It is not metabolized in the body. Excretion: Excreted mainly through urine & small amount is seen in breast milk.

Onset of Action for Ceftazidime

Sudden

Duration of Action for Ceftazidime

8 hours

Half Life of Ceftazidime

1.8 hours

Side Effects of Ceftazidime

1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
2.Rashes & allergic manifestation
3.Vaginitis
4.Pruritus
5.Candidiasis
6.Headache
7.Dizziness
8.Seizures
9.Pseudo membranous colitis
10.Nausea
11.Vomiting
12.Elevated liver enzymes
13.Leucopenia
14.Thrombocytopenia

Contra-indications of Ceftazidime

1.Hypersensitivity to the drug or other cephalosporins
2.Never administer along with chloramphenicol.

Special Precautions while taking Ceftazidime

1.Renal impairment
2.Those allergic to penicillins
3. Neuromuscular disorders

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

May be used, but arginine containing formulation like ceptaz is contraindicated
Neonates: may be used ,but arginine containing formulation like ceptaz is contraindicated

Indications for Ceftazidime

1.Febrile neutropenic patients with haematological malignancies
2.Burn infections
3.Respiratory tract infections
4.Urinogenital tract infections
5.Bone & Joint infections
6.Septicemia
7.CNS infections
8.Skin & wound infections
9.Meningitis.

Interactions for Ceftazidime

No known interaction.

Typical Dosage for Ceftazidime

Adults: 0.5g to 2gm I.M. or I.V. three times daily.
Children: 30 to 50 mg/kg/day I.M or I.V. three times daily.
Neonates: 30mg/kg I.V. two times daily

Schedule of Ceftazidime

Storage Requirements for Ceftazidime

Store in a refrigerator at -20 degree celciousss

Effects of Missed Dosage of Ceftazidime

Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.

Effects of Overdose of Ceftazidime

Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment includes removal of drug from the body by dialysis & supportive

Tazobactam

About Tazobactam

A Penicillanic acid sulfone beta-lactamase inhibitor, penams, To increase the antibacterial activity of penicillins against ?-lactamase?producing organisms.

Mechanism of Action of Tazobactam

Tazobactam is a Penicillanic acid sulfone beta lactamase inhibitor.Sulbactam has no significant antimicrobial activity, despite sharing the ?-lactam ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Tazobactam to act as a competitive inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics. This inhibition restores the antibacterial activity of beta-lactam antibiotics against ?-lactamase-secreting resistant bacteria.It is usually given in combination with Piperacillin.

Pharmacokinets of Tazobactam

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Onset of Action for Tazobactam

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Duration of Action for Tazobactam

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Half Life of Tazobactam

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Side Effects of Tazobactam

1.Gastrointestinal disturbances
2.Headache
3.Dizziness
4.Insomnia
5.Rash
6.Pain
7.Hypertension
8.Edema
9.Pruritus
10.Agitation
11.Local reactions

Contra-indications of Tazobactam

Hypersensitivity to Tazobactam

Special Precautions while taking Tazobactam

1.Renal impairment
2.Cystic fibrosis
3.Haematopoiesis
4.Monitor electrolytes
5.Discontinue if bleeding disorders occur

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Contraindicated

Indications for Tazobactam

1.Skin infections
2.Pneumonia
3.Postpartum endometritis
4.Pelvic inflammatory disease
5.Appendicitis
6.Peritonitis

Interactions for Tazobactam

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Typical Dosage for Tazobactam

IV Infusion over 30 minutes.
Adults: 3 to 4 grams of Piperacillin, in combination with 0.375 to 0.5 grams of Tazobactam, every 6 - 8 hours for 7 - 10 days.

Schedule of Tazobactam

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Storage Requirements for Tazobactam

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Effects of Missed Dosage of Tazobactam

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Effects of Overdose of Tazobactam

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Home Delivery for Ceftazidime +Tazobactam in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ceftazidime +tazobactam.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ceftazidime +tazobactam and other medicines and health products. Home delivery services for ceftazidime +tazobactam may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ceftazidime +tazobactam only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ceftazidime +tazobactam before they complete the sale. You can get this information while placing the order for ceftazidime +tazobactam with the pharmacy.

Ceftazidime +Tazobactam is a generic medicine name and there are several brands available for it. Some of the brands for ceftazidime +tazobactam might be better known than ceftazidime +tazobactam itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ceftazidime +tazobactam in stock, you can ask for one of the branded alternatives for ceftazidime +tazobactam.