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- Pharmacology For Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + Calcium
Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + Calcium Pharmacology
Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + Calcium
About Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/AMechanism of Action of Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/APharmacokinets of Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/AOnset of Action for Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/ADuration of Action for Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/AHalf Life of Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/ASide Effects of Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/AContra-indications of Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/ASpecial Precautions while taking Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + Calcium1.Calcium deficiency states
2.Osteoporosis
3.Rickets
4.Osteomalacia
5.Supplement
Interactions for Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/ATypical Dosage for Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/ASchedule of Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/AStorage Requirements for Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/AEffects of Missed Dosage of Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/AEffects of Overdose of Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + CalciumN/ACalcitriol
About CalcitriolN/AMechanism of Action of CalcitriolCalcitriol is a 1, 25-dihydroxycholecalciferol or a Vitamin D analogue. It increases the absorption of Calcium from intestine by forming a calcium binding protein. It reverses the signs of rickets and osteomalacia.Pharmacokinets of CalcitriolAbsorption: It is readily absorbed after oral administration. Distribution: It is widely distributed in protein bound form. Metabolism: It undergoes metabolism in the liver and kidney. Excretion: It is excreted mainly in the faeces.Onset of Action for Calcitriol2 - 6 hoursDuration of Action for Calcitriol3 - 5 daysHalf Life of Calcitriol3 - 8 hoursSide Effects of Calcitriol1. Nausea
2. Vomiting
3. Constipation
4. Headache
5. Somnolence
6. Weakness
7. Hypertension
8. Bone and muscle pain
9. Pruritus
10. Weight loss
11. Polyuria
12. Metallic taste
13. Anorexia
14. Dry mouth
Contra-indications of Calcitriol1. Hypercalcaemia
2. Metastatic calcification
3. Plasma phosphorus level greater than 6 mg/dl
Special Precautions while taking Calcitriol1.Liver impairment
2.Renal impairment
3.Monitor plasma calcium and creatinine in patients receiving high doses
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Calcitriol1.Management of Hypocalcaemia
2.Management of hypoparathyroidism and pseudohypoparathyroidismInteractions for CalcitriolN/ATypical Dosage for CalcitriolAdult:
Oral:
Management of hypocalcaemia:0.25mcg/day.Dosage can be increased by 0.25mcg/day at 1 - 2 month interval.Maintenance dose:0.25 - 1 mcg/ day.
Management of hypoparathyroidism and psedohypothyroidism:0.25mcg/day in the morning and dosage can be incresed at 2 - 4 week intervals.Maintenance dose: 0.5 - 2 mcg/day
Children:above 6 years:same as adult dose
Children 1 - 5 years: 0.25 - 0.75mcg/day Schedule of CalcitriolN/AStorage Requirements for CalcitriolStore in a well closed container.Protect from heat,light and moisture.Keep out of the reach of children.Effects of Missed Dosage of CalcitriolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Continue the regular schedule.Effects of Overdose of CalcitriolGive supportive mesures and symptomatic treatment. Eicosapentaenoic Acid
About Eicosapentaenoic AcidAn omega-3 fatty acid, Essential fatty acid, dietary supplement, Anti atherosclerotic.Mechanism of Action of Eicosapentaenoic AcidEicosapentaenoic acid is an omega-3 fatty acid. It is found with Docosapentaenoic acid. Omega-3 fatty acids are of polyunsaturated fatty acids that derives from food. They help to lower triglycerides and cholesterol and increase HDL cholesterol (the Good cholesterol) and thus improves lipid profile. Omega 3 fatty acids may also act as an anticoagulant to prevent blood clotting. They have anti-inflammatory actions and also lower high blood pressure. The incorporation of Omega-3 fatty acids in the membranes of the cells increases the physicochemical stability and functional integrity. It also makes the cells less susceptible to oxidative damage and also decreases the formation of lipid peroxidases. They protect from cardiovascular disorders and may also reduce the risks and symptoms for other disorders including diabetes, dementia, rheumatoid arthritis, asthma, stroke, inflammatory bowel disease, ulcerative colitis, mental decline, and some cancers. They aid in proper functioning of central nervous system.
Hypolipidaemic action: It produces a reduction in plasma triglycerides by reducing bad cholesterol or very low density lipoproteins.
Antiinflammatory action: Omega - 3 fatty acids are long chain poly unsaturated fatty acids.They compete with arachidonic acid for cyclo-oxygenase and lipoxygenase They inhibits inflammatory mediators by inhibiting leukotriene synthesis pathway.
Antithrombotic effect: They promote vasodilatation, a reduction in platelet aggregation, increased bleeding time and decreased platelet counts
Pharmacokinets of Eicosapentaenoic AcidN/AOnset of Action for Eicosapentaenoic AcidN/ADuration of Action for Eicosapentaenoic AcidN/AHalf Life of Eicosapentaenoic AcidN/ASide Effects of Eicosapentaenoic Acid1.Loose stools
2.Abdominal discomfort
3.Belching
4.Prolong bleeding time slightly
5.Nausea
6.Vomiting
7.DiarrhoeaContra-indications of Eicosapentaenoic AcidHypersensitivity to the drugSpecial Precautions while taking Eicosapentaenoic Acid1.Haemorrhagic disorders
2.Patient on anticoagulants therapy
3.Hepatic impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Infants:ContraindicatedIndications for Eicosapentaenoic Acid1.Coronary artery disease
2.Hypertension
3.Atherosclerosis related disorders
4.Obesity
5.Fatty diet
6.Hyperlipidaemia
7.Smoking
8.Diabetes
Interactions for Eicosapentaenoic AcidN/ATypical Dosage for Eicosapentaenoic Acid180mg once or twice dailySchedule of Eicosapentaenoic AcidN/AStorage Requirements for Eicosapentaenoic AcidStore in airtight containers. Protect from light.
Effects of Missed Dosage of Eicosapentaenoic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Eicosapentaenoic AcidGive supportive measures and symptomatic treatment.Docosahexenoic Acid
About Docosahexenoic AcidAn omega-3 fatty acid(polyunsaturated fatty acids, PUFAs), An essential fatty acid, brain food ,Antiatherosclerotic.Mechanism of Action of Docosahexenoic AcidIt is found with Eicosapentaenoic acid. Omega-3 fatty acids are of polyunsaturated fatty acids that derives from food. They help to lower triglycerides and cholesterol and increase HDL cholesterol (the Good cholesterol) and thus improves lipid profile. Omega 3 fatty acids may also act as an anticoagulant to prevent blood clotting. They have anti-inflammatory actions and also lower high blood pressure. The incorporation of Omega-3 fatty acids in the membranes of the cells increases the physicochemical stability and functional integrity. It also makes the cells less susceptible to oxidative damage and also decreases the formation of lipid peroxidases. They protect from cardiovascular disorders and may also reduce the risks and symptoms for other disorders including diabetes, dementia, rheumatoid arthritis, asthma, stroke, inflammatory bowel disease, ulcerative colitis, mental decline, and some cancers. They aid in proper functioning of central nervous system.
Hypolipidaemic action: It produces a reduction in plasma triglycerides by reducing bad cholesterol or very low density lipoproteins.
Antiinflammatory action: Omega - 3 fatty acids are long chain poly unsaturated fatty acids.They compete with arachidonic acid for cyclo-oxygenase and lipoxygenase They inhibits inflammatory mediators by inhibiting leukotriene synthesis pathway.
Antithrombotic effect: They promote vasodilatation, a reduction in platelet aggregation, increased bleeding time and decreased platelet counts
Pharmacokinets of Docosahexenoic AcidN/AOnset of Action for Docosahexenoic AcidN/ADuration of Action for Docosahexenoic AcidN/AHalf Life of Docosahexenoic AcidN/ASide Effects of Docosahexenoic Acid1.Loose stools
2.Abdominal discomfort
3.Belching
4.Prolong bleeding time slightly
5.Nausea
6.Vomiting
7.Diarrhoea
8.Constipation
Contra-indications of Docosahexenoic AcidHypersensitivity to the drugSpecial Precautions while taking Docosahexenoic Acid1.Haemorrhagic disorders
2.Patient on anticoagulants therapy
3.Hepatic impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Infants: ContraindicatedIndications for Docosahexenoic Acid1.Coronary artery disease
2.Hypertension
3.Atherosclerosis related disorders
4.Obesity
5.Fatty diet
6.Hyperlipidaemia
7.Smoking
8.Diabetes
Interactions for Docosahexenoic AcidN/ATypical Dosage for Docosahexenoic Acid120 - 240 mg / day in single or 2 divided dose with Eicosapentaenoic acid.Schedule of Docosahexenoic AcidN/AStorage Requirements for Docosahexenoic AcidStore in airtight containers. Protect from light.
Effects of Missed Dosage of Docosahexenoic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Docosahexenoic AcidGive supportive measures and symptomatic treatment.About N/AMechanism of Action of N/APharmacokinets of N/AOnset of Action for N/ADuration of Action for N/AHalf Life of N/ASide Effects of N/AContra-indications of N/ASpecial Precautions while taking N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for N/AInteractions for N/ATypical Dosage for N/ASchedule of N/AStorage Requirements for N/AEffects of Missed Dosage of N/AEffects of Overdose of N/AFolic Acid
About Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
C (Parenteral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.Sodium borate
About Sodium borateBoron compound, Cleaning product, mild antiseptic.Mechanism of Action of Sodium borateN/APharmacokinets of Sodium borateN/AOnset of Action for Sodium borateN/ADuration of Action for Sodium borateN/AHalf Life of Sodium borateN/ASide Effects of Sodium borateN/AContra-indications of Sodium borateN/ASpecial Precautions while taking Sodium borateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Sodium borateN/AInteractions for Sodium borateN/ATypical Dosage for Sodium borateN/ASchedule of Sodium borateN/AStorage Requirements for Sodium borateN/AEffects of Missed Dosage of Sodium borateN/AEffects of Overdose of Sodium borateN/ACalcium
About CalciumCalcium is necessary for cardiac function, muscle contraction, nervous activity, coagulation of blood and for maintaining structural integrity of cell membranes.
Plasma concentration of calcium is kept in normal range by three endocrine factors which control metabolism of calcium. These are (a) Parathyroid hormone, (b) Calcitonin, (c) Vitamin D. Calcium in plasma is bound to albumin, is complexed with anions (e.g. phosphate) and as diffusible ionic calcium. The physiological effects are exerted by ionic calcium. The predominant source of calcium is dairy products and the daily intake varies from 200 - 2500 mg. Adequate calcium intake is particularly important during periods of bone growth in childhood and adolescence and during pregnancy and lactation.
Patients with advanced renal insufficiency exhibit phosphate retention and some degree of hyperphosphataemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy and soft tissue calcification. Calcium acetate, when taken with meals, combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the faeces.
Deficiency signs and symptoms: Osteoporosis, pathological fractures, brittle nails and hair.Mechanism of Action of CalciumCalcium is essential for maintaining the functional integrity of nervous, muscular, and skeletal system. It controls excitability of nerves and muscles and regulates permeability of cell membrane. It also regulates cell adhesion and maintains integrity of cell membrane. Calcium acts as intracellular messenger for hormones, autacoids, and transmitters. It is required for excitation-contraction coupling in all types of muscle and excitation-secretion coupling in exocrine and endocrine glands. It is essential for release of transmitters from nerve endings and other release reactions. It is also essential for impulse generation in heart and determines level of automaticity and
A-V conduction. Calcium is also required for blood-coagulation.
Pharmacokinets of CalciumAbsorption: Actively absorbed from gastrointestinal tract in an ionized form; and vitamin D in it`s active form is required for calcium absorption, Distribution: Distributed mainly in to skeletal tissue (99%) and 1% is distributed equally between the intracellular and extra cellular fluid. CSF levels are about half of the serum calcium levels, Metabolism: Not significantly metabolized in the body, Excretion: Excreted mainly through faeces and a small amount is excreted through urine.Onset of Action for CalciumN/ADuration of Action for CalciumN/AHalf Life of CalciumN/ASide Effects of Calcium1.Constipation
2.Bloating
3.Excess gas
4.Anorexia
5.Nausea
6.Vomiting
7.Abdominal pain
8.Thirst
9.Hypercalcaemia
10.Polyuria
11.Dry mouth
12.Delirium
13.Confusion
Contra-indications of Calcium1.Renal calculi
2.Hypophosphataemia
3.Hypercalcaemia
4.Ventricular fibrillation.
Special Precautions while taking Calcium1.Renal impairment
2.Cardiac diseases
3.Sarcoidosis
4.Cor pulmonale
5.Respiratory acidosis
6.Respiratory failure
7.End stage renal failure
8.Hypoparathyroid patients
9.Digitalized patients
10.Prolonged use of therapeutic amounts.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Calcium1.Hypocalcaemia
2.Calcium and vitamin D deficiency
3.Calcium deficiency during pregnancy and lactation
4.Rickets
5.Prevention of osteoporosis in postmenopausal women
6.Chronic renal failure.
Interactions for CalciumN/ATypical Dosage for CalciumOral: 500mg to 2g daily in two to four divided doses.
Hypocalcaemia:
Adults: 1g daily. Increases to 2g daily if required.
Prevention of osteoporosis: 1 to 1.5g daily.
Children: 45 to 65mg/kg daily.
Neonates: 50 to 150mg/kg and should not exceed 1g.
Schedule of CalciumN/AStorage Requirements for CalciumStore in a well closed container in a cool and dry place. Protect from light.
Effects of Missed Dosage of CalciumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CalciumRemove calcium from stomach by induced emesis and gastric lavage. Provide symptomatic treatment and supportive measures.Home Delivery for Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + Calcium in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including calcitriol + eicosapentaenoic acid + docosahexenoic acid + mecobalamine + folic acid + sodium borate + calcium.
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Calcitriol + Eicosapentaenoic acid + Docosahexenoic acid + Mecobalamine + Folic Acid + Sodium Borate + Calcium is a generic medicine name and there are several brands available for it. Some of the brands for calcitriol + eicosapentaenoic acid + docosahexenoic acid + mecobalamine + folic acid + sodium borate + calcium might be better known than calcitriol + eicosapentaenoic acid + docosahexenoic acid + mecobalamine + folic acid + sodium borate + calcium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have calcitriol + eicosapentaenoic acid + docosahexenoic acid + mecobalamine + folic acid + sodium borate + calcium in stock, you can ask for one of the branded alternatives for calcitriol + eicosapentaenoic acid + docosahexenoic acid + mecobalamine + folic acid + sodium borate + calcium.