Mebeverine + Chlordiazepoxide Pharmacology

Mebeverine + Chlordiazepoxide

About Mebeverine + Chlordiazepoxide
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Mechanism of Action of Mebeverine + Chlordiazepoxide
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Pharmacokinets of Mebeverine + Chlordiazepoxide
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Onset of Action for Mebeverine + Chlordiazepoxide
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Duration of Action for Mebeverine + Chlordiazepoxide
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Half Life of Mebeverine + Chlordiazepoxide
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Side Effects of Mebeverine + Chlordiazepoxide
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Contra-indications of Mebeverine + Chlordiazepoxide
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Special Precautions while taking Mebeverine + Chlordiazepoxide
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Mebeverine + Chlordiazepoxide
1.Irritable bowel syndrome
2.GI tract spasm
Interactions for Mebeverine + Chlordiazepoxide
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Typical Dosage for Mebeverine + Chlordiazepoxide
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Schedule of Mebeverine + Chlordiazepoxide
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Storage Requirements for Mebeverine + Chlordiazepoxide
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Effects of Missed Dosage of Mebeverine + Chlordiazepoxide
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Effects of Overdose of Mebeverine + Chlordiazepoxide
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Mebeverine

About Mebeverine
Reserpine derivative, antimuscarinic, a musculotropic antispasmodic, Motility stimulant.
Mechanism of Action of Mebeverine
Mebeverine has a direct relaxant effect on smooth muscle. This will inhibits gastrointestinal propulsive motility and gastric acid secretion.
Pharmacokinets of Mebeverine
Absorption: It is well absorbed after oral administration.
Distribution:
Metabolism: Mebeverine is rapidly and extensively undergoes hydrolysis and forms Veratric acid
Excretion: Metabolites are excreted mainly in urine
Onset of Action for Mebeverine
N/A
Duration of Action for Mebeverine
N/A
Half Life of Mebeverine
1.1 hours
Side Effects of Mebeverine
1.Gastrointestinal disturbances
2.Heart burn
3.Dizziness
4.Dyspepsia
Contra-indications of Mebeverine
1.Hypersensitivity to Mebeverine
Special Precautions while taking Mebeverine
1.Hepatic impairment
2.Renal impairment
3.Heart failure
4.Ischemic heart disease
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Mebeverine
1.Irritable bowel syndrome
Interactions for Mebeverine
N/A
Typical Dosage for Mebeverine
Adult: 405 mg / day in 3- divided doses to be taken 20 minutes before meals. Dose can be gradually reduced after 1 week if sufficient response is obtained.
Children above 10 years: 405 mg / day in 3- divided doses to be taken 20 minutes before meals. Dose can be gradually reduced after 1 week if sufficient response is obtained.
Children below 10 years: contraindicated.
Schedule of Mebeverine
H
Storage Requirements for Mebeverine
Store in a cool dry place. Protect from heat and light.
Keep out of the reach of children
Effects of Missed Dosage of Mebeverine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Mebeverine
Give supportive measures and symptomatic treatment.

Chlordiazepoxide

About Chlordiazepoxide
Benzodiazepine derivative, Sedative /hypnotic, Antianxiety and skeletal muscle relaxant.
Mechanism of Action of Chlordiazepoxide
Chlordiazepoxide mainly acts on Limbic system and ascending reticular formation in the CNS. It binds to the BZD receptor. The binding will facilitates GABA mediated chloride channel opening and produce hyperpolarisation. This will increase the concentration of inhibitory neurotransmitter GABA and chloride ions in the CNS and decreases firing rate of neurons. This in turn alters normal excitatory functions of the body.
Pharmacokinets of Chlordiazepoxide
Absorption: It is absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It is metabolised to active metabolite in the liver. Excretion: Most metabolites are excreted through urine
Onset of Action for Chlordiazepoxide
1 - 2 hour
Duration of Action for Chlordiazepoxide
12 - 24 hour
Half Life of Chlordiazepoxide
5 - 30 hour
Side Effects of Chlordiazepoxide
1.Ataxia
2.Drowsiness
3.Lethargy
4.Hallucination
5.Nausea
6.Constipation
7.Amnesia
8.Dependence
9.Pain at the site of injection
10.Confusion
11.Depression
12.Mood changes
Contra-indications of Chlordiazepoxide
Hypersensitivity to Benzodiazepines
Special Precautions while taking Chlordiazepoxide
1.Renal impairment
2.Hepatic impairment
3.Myasthenia gravis
4.Respiratory disease
5.Jaundice
6.Use caution while driving vehicles, operating machines or other dangerous activities
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated.
Children Related Information
Use with caution
children < 6 years: contraindicated
NEONATES- contraindicated
Indications for Chlordiazepoxide
1. Anxiety
2.Treatment of alcohol withdrawal symptom
3. Insomnia
4. Pre and post operative apprehension
Interactions for Chlordiazepoxide
Alcohol & Other CNS Depressants: Enhanced CNS effects.
Aminophylline: Antagonizes the sedative effect.
Cimetidine, Oral contraceptives, Disulfiram, Fluoxetine, Isoniazid, Ketoconazole, Metoprolol, Propoxyphene, Propranolol.
Valproic acid: Elimination of chlordiazepoxide decreased due to inhibition of hepatic metabolism leading to enhanced activity.
Digoxin: Increase in serum concentration of Digoxin.
Imipramine & Desipramine: Enhanced activity of these drugs.
Levodopa : Decrease in antiparkinsonism efficacy.
Morphine, Pethidine, Atropine and Magnesium trisilicate: Absorption of chlordiazepoxide is impaired.
Probenecid: May cause rapid onset or prolonged effect.
Rifampicin: Decreases efficacy.
Typical Dosage for Chlordiazepoxide
Adults: 5 - 10 mg 3 - 4 times daily
Severe anxiety: 20 - 25 mg 3 - 4 times daily
Treatment of alcohol withdrawal symptom: 25 - 100 mg daily; Depending on the patient`s condition dose can be reduced after 2 - 3 weeks
Pre and post operative apprehension: 5 - 10 mg 3 - 4 times daily; the drug should be given one day before surgery in pre operative apprehension
Children: 5mg 3 - 4 times daily.
Schedule of Chlordiazepoxide
H
Storage Requirements for Chlordiazepoxide
Store at temperature 15 - 30 degree C.Protect from light and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Chlordiazepoxide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Chlordiazepoxide
Give support and symptomatic treatment. Induce emesis or gastric lavage has to be done followed by charcoal administration. Flumazenil can be given as antagonist.

Home Delivery for Mebeverine + Chlordiazepoxide in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mebeverine + chlordiazepoxide and other medicines and health products. Home delivery services for mebeverine + chlordiazepoxide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

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Mebeverine + Chlordiazepoxide is a generic medicine name and there are several brands available for it. Some of the brands for mebeverine + chlordiazepoxide might be better known than mebeverine + chlordiazepoxide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mebeverine + chlordiazepoxide in stock, you can ask for one of the branded alternatives for mebeverine + chlordiazepoxide.