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- Pharmacology For Montelukast + Desloratadine
Montelukast + Desloratadine Pharmacology
Montelukast + Desloratadine
About Montelukast + DesloratadineN/AMechanism of Action of Montelukast + DesloratadineN/APharmacokinets of Montelukast + DesloratadineN/AOnset of Action for Montelukast + DesloratadineN/ADuration of Action for Montelukast + DesloratadineN/AHalf Life of Montelukast + DesloratadineN/ASide Effects of Montelukast + DesloratadineN/AContra-indications of Montelukast + DesloratadineN/ASpecial Precautions while taking Montelukast + DesloratadineN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Montelukast + Desloratadine1.Persistent allergic rhinitis
2.Asthma
3.Skin allergies
Interactions for Montelukast + DesloratadineN/ATypical Dosage for Montelukast + DesloratadineN/ASchedule of Montelukast + DesloratadineN/AStorage Requirements for Montelukast + DesloratadineN/AEffects of Missed Dosage of Montelukast + DesloratadineN/AEffects of Overdose of Montelukast + DesloratadineN/AMontelukast
About MontelukastLeukotriene(CysLT1) Receptor Antagonist, Antiinflammatory,antiasthma.Mechanism of Action of MontelukastMontelukast is competitively and selectively antagonizes CysLT1 receptor (leukotrienes receptor) mediated Bronchoconstriction.Montelukast inhibits physiologic actions of LTD 4 at the CysLT1 receptor without any agonist activity.
Pharmacokinets of MontelukastAbsorption: Montelukast is rapidly absorbed after oral administration and its bioavailability is about 60 - 70%.
Distribution: It is minimally distributed to the tissues in protein bound form (99%)
Metabolism: It is extensively metabolised in the liver.
Excretion: Montelukast is excreted in the faeces.
Onset of Action for MontelukastN/ADuration of Action for MontelukastN/AHalf Life of Montelukast2.75 - 5.5 hoursSide Effects of Montelukast1.Headache
2.Dizziness
3.Nasal congestion
4.Sore throat
5.Abdominal pain
6.Fatigue
7.Asthenia
8.Cough
9.Influenza
10.Rash
11.Fever
12.Trauma
13.Trauma
14.Dyspepsia
Contra-indications of Montelukast1.Hypersensitivity to Montelukast
2.Acute asthmatic attacksSpecial Precautions while taking MontelukastN/APregnancy Related InformationUse with caution.Old Age Related InformationMay be used.Breast Feeding Related InformationUse with caution.Children Related InformationMay be used
CHILDREN below 6 years : contraindicated
NEONATES: contraindicated
Indications for MontelukastAsthma.Interactions for MontelukastBarbiturates & Primidone: Plasma concentration of montelukast is reduced by phenobarbital.
Typical Dosage for MontelukastAdult: 10 mg / day at bed time
Children (6 - 14 years): 5mg/day at bed time
Schedule of MontelukastN/AStorage Requirements for MontelukastStore at room temperature. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of MontelukastTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MontelukastGive supportive measures and symptomatic treatmentDesloratadine
About DesloratadineSecond Generation long-acting tricyclic H1 Antagonist, Antihistamine.Mechanism of Action of DesloratadineThis second generation antihistamine has a selective peripheral H1-antagonist action.Desloratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This inhibit the action of histamine, which subsequently leads to temporary relief of the negative symptoms brought by histaminePharmacokinets of DesloratadineAbsorption- Rapidly absorbed after oral administration
Distribution- Widely distributed in the body. 85% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excrete through urine (40% as conjugated form) and feces
Onset of Action for DesloratadineN/ADuration of Action for DesloratadineN/AHalf Life of DesloratadineIts plasma half life is 50hrsSide Effects of Desloratadine1. Dizziness
2. Dry mouth
3. Dysmenorrhea
4. Dyspepsia
5. Belching
6. Heartburn
7. Indigestion
8. Stomach discomfort
9. Fatigue
10. Myalgia
11. Difficulty in moving
12. Pharyngitis
13. Fever
14. Hoarseness
15. Runny nose
16. Tender swollen glands in neck
17. Trouble in swallowing
18. Voice changes
19. Somnolence
20. NauseaContra-indications of Desloratadine1. Dizziness
2. Dry mouth
3. Dysmenorrhea
4. Dyspepsia
5. Belching
6. Heartburn
7. Iindigestion
8. Stomach discomfort
9. Fatigue
10. Myalgia
11. Difficulty in moving
12. Pharyngitis
13. Fever
14. Hoarseness
15. Runny nose
16. Tender swollen glands in neck
17. Trouble in swallowing
18. Voice changes
19. Somnolence
20. NauseaSpecial Precautions while taking Desloratadine1. Liver disease
2. Kidney disease
3. Phenylketonuria
4. Any work which require mental alertness such as driving and machine operation
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Desloratadine1. Hay fever
2. Watery eyes
3. Runny nose
4. Itching eyes
5. Sneezing
6. Hives
7. Decongestant
Interactions for DesloratadineN/ATypical Dosage for DesloratadineOral-
Adult (general dose)-
5mg/day
Children (>12yrs)-Same as adult
Schedule of DesloratadineN/AStorage Requirements for DesloratadineStored at room temperature. Protect from light and excessive heat. Keep out of reach of childrenEffects of Missed Dosage of DesloratadineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the doseEffects of Overdose of DesloratadineGive symptomatic and supportive treatmentHome Delivery for Montelukast + Desloratadine in Your City
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Montelukast + Desloratadine is a generic medicine name and there are several brands available for it. Some of the brands for montelukast + desloratadine might be better known than montelukast + desloratadine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have montelukast + desloratadine in stock, you can ask for one of the branded alternatives for montelukast + desloratadine.