Minoxidil + Finasteride Pharmacology

Minoxidil + Finasteride

About Minoxidil + Finasteride
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Mechanism of Action of Minoxidil + Finasteride
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Pharmacokinets of Minoxidil + Finasteride
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Onset of Action for Minoxidil + Finasteride
N/A
Duration of Action for Minoxidil + Finasteride
N/A
Half Life of Minoxidil + Finasteride
N/A
Side Effects of Minoxidil + Finasteride
1.Nausea or vomiting
2.Changes in skin or hair pigmentation
3.Tenderness in the breast area
4.Fragile or thin skin at the area of application
5.Itching or irritation at the point of application
Contra-indications of Minoxidil + Finasteride
N/A
Special Precautions while taking Minoxidil + Finasteride
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Minoxidil + Finasteride
Hair loss treatment.
Interactions for Minoxidil + Finasteride
N/A
Typical Dosage for Minoxidil + Finasteride
Solution is applied in the mornings and/or evenings directly onto the area which is thinning or bald.
Before applying, ensure the scalp area is dry. Next, spread the solution evenly over the affected area(s). Finally, leave to allow to air dry without covering your scalp. Once completely dry, you are able to hair products, cover as you like, and lay down.
Always clean your hands using soap both before, and after applying Solution.

Schedule of Minoxidil + Finasteride
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Storage Requirements for Minoxidil + Finasteride
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Effects of Missed Dosage of Minoxidil + Finasteride
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Effects of Overdose of Minoxidil + Finasteride
N/A

Minoxidil

About Minoxidil
A potassium channel agonist,Direct-Acting Vasodilator, Hair- growth stimulant,In androgenic alopecia.
Mechanism of Action of Minoxidil
Minoxidil works by activating PGHS 1 (prostaglandin endoperoxide synthase-1) which helps promote hair growth. It enhances follicular size and results in thicker hair shafts and stimulates and prolongs the anagen phase of the hair cycle. This will results in longer and increased number of hairs.
Pharmacokinets of Minoxidil
Absorption: It is poorly absorbed after topical administration
Onset of Action for Minoxidil
N/A
Duration of Action for Minoxidil
N/A
Half Life of Minoxidil
N/A
Side Effects of Minoxidil
1.Headache
2.Dizziness
3.Irritation
4.Itch
5.Contact dermatitis
6.Palpitation
7.Irregular heart beat
8.Nausea
9.Vomiting
10.Diarrhoea
11.Dermatitis
12.Chest pain
13.Hypertension
14.Hypotension
Contra-indications of Minoxidil
1.Hypersensitivity to Minoxidil
Special Precautions while taking Minoxidil
1.Renal impairment
2.Hepatic impairment
3.Cardiac impairment
4.Avoid contact with broken area, eye and mucus membrane
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution
above 65 years: contraindicated
Breast Feeding Related Information
Contraindicated.
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Minoxidil
1. Alopecia areata
2. Androgenic alopecia
Interactions for Minoxidil
N/A
Typical Dosage for Minoxidil
Topical
Adult: Apply 1 ml solution on the dry scalp and hair 2 times daily for 4 months or longer
Children: contraindicated
Schedule of Minoxidil
N/A
Storage Requirements for Minoxidil
Store at room temperature. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Minoxidil
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Minoxidil
Give supportive measures and symptomatic treatment. Thoroughly wash the hair. In accidental ingestion drug can be removed from the body by inducing emesis or gastric lavage. Absorption of the drug can be reduced by administration of activated charcoal

Finasteride

About Finasteride
5 Alpha-Reductase Inhibitor, Synthetic anti-androgen.
Mechanism of Action of Finasteride
This synthetic 4-azasteroid derivative competitively inhibits steroid 5alpha reductase, which is an enzyme responsible for active androgen dehydrotestosterone (this enzyme influences the development of prostate gland, so decreasing level of this hormone relieve the symptoms associated with benign prostatic hyperplasia)from testosterone.
Pharmacokinets of Finasteride
Absorption- Poorly absorbed after oral administration
Distribution- Widely distributed in the body. It crosses the blood-brain barrier. 90% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites. Two metabolites, the t-butyl side chain monohydroxylated and monocarboxylic acid metabolites have been identified that possess not more than 20% of the 5alpha-reductase inhibitory activity of finasteride.
Excretion- It is excreted through urine and feces
Onset of Action for Finasteride
After a few months
Duration of Action for Finasteride
24hrs
Half Life of Finasteride
Its plasma half life is 4.8-6 hours
Side Effects of Finasteride
1. Increased libido
2. Breast tenderness
3. Impotence
4. Hypersensitivity reactions.
5. Impotence (inability to have or maintain an erection)
6. Nipple discharge
Contra-indications of Finasteride
Contraindicated in patients with hypersensitivity to the drug
Special Precautions while taking Finasteride
1. Hepatic dysfunction
2. Patients with large residual urine volume
3. Increase in PSA level
Pregnancy Related Information
Contraindicated
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Finasteride
1. Benign prostatic hyperplasia
2. 1st stage of prostate cancer
3. Hirsuitism
4. Acne
5. Adjuvant therapy of radical prostectomy
6. Androgenic baldness
Interactions for Finasteride
Theophylline: Increased theophylline clearance and decreased its half-life.
Typical Dosage for Finasteride
Oral-
Adult-
5mg/day for 6 to 12 months
Androgenic baldness: 1mg/day for 3 months or more
Schedule of Finasteride
N/A
Storage Requirements for Finasteride
Store it at room temperature and away from excess heat and moisture
Effects of Missed Dosage of Finasteride
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Finasteride
Give symptomatic and supportive treatment

Home Delivery for Minoxidil + Finasteride in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for minoxidil + finasteride and other medicines and health products. Home delivery services for minoxidil + finasteride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take minoxidil + finasteride only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for minoxidil + finasteride before they complete the sale. You can get this information while placing the order for minoxidil + finasteride with the pharmacy.

Minoxidil + Finasteride is a generic medicine name and there are several brands available for it. Some of the brands for minoxidil + finasteride might be better known than minoxidil + finasteride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have minoxidil + finasteride in stock, you can ask for one of the branded alternatives for minoxidil + finasteride.