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- Pharmacology For Betamethasone Dipropionate + Zinc Sulphate
Betamethasone Dipropionate + Zinc Sulphate Pharmacology
Betamethasone Dipropionate + Zinc Sulphate
About Betamethasone Dipropionate + Zinc SulphateN/AMechanism of Action of Betamethasone Dipropionate + Zinc SulphateN/APharmacokinets of Betamethasone Dipropionate + Zinc SulphateN/AOnset of Action for Betamethasone Dipropionate + Zinc SulphateN/ADuration of Action for Betamethasone Dipropionate + Zinc SulphateN/AHalf Life of Betamethasone Dipropionate + Zinc SulphateN/ASide Effects of Betamethasone Dipropionate + Zinc SulphateN/AContra-indications of Betamethasone Dipropionate + Zinc SulphateN/ASpecial Precautions while taking Betamethasone Dipropionate + Zinc SulphateN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Betamethasone Dipropionate + Zinc SulphateCorticosteriod-responsive dermatoses.Interactions for Betamethasone Dipropionate + Zinc SulphateN/ATypical Dosage for Betamethasone Dipropionate + Zinc SulphateN/ASchedule of Betamethasone Dipropionate + Zinc SulphateN/AStorage Requirements for Betamethasone Dipropionate + Zinc SulphateN/AEffects of Missed Dosage of Betamethasone Dipropionate + Zinc SulphateN/AEffects of Overdose of Betamethasone Dipropionate + Zinc SulphateN/ABetamethasone dipropionate
About Betamethasone dipropionateA synthetic glucocorticoid, anti-inflammatory.Mechanism of Action of Betamethasone dipropionateThe drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Betamethasone dipropionateAbsorption: It is absorbed in to the systemic circulation and the amount is depending on the potency, amount applied and the nature of the skin at the site of application. Absorption increases at the site of skin damage, inflammation or occlusion.
Onset of Action for Betamethasone dipropionateN/ADuration of Action for Betamethasone dipropionateN/AHalf Life of Betamethasone dipropionateN/ASide Effects of Betamethasone dipropionate1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Betamethasone dipropionate1.Hypersensitivity to Betamethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Betamethasone dipropionate1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Betamethasone dipropionate1.Eczema
2.Psoriasis
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Betamethasone dipropionateN/ATypical Dosage for Betamethasone dipropionateApply thinly 1 -2 times daily.Schedule of Betamethasone dipropionateHStorage Requirements for Betamethasone dipropionateStore at room temperature in a well closed; light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Betamethasone dipropionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Betamethasone dipropionateProvide symptomatic treatment and supportive measures.Zinc Sulphate
About Zinc SulphateZinc compound, An astringent , Adjunctive treatment of Wilson?s disease.Mechanism of Action of Zinc SulphateN/APharmacokinets of Zinc SulphateN/AOnset of Action for Zinc SulphateN/ADuration of Action for Zinc SulphateN/AHalf Life of Zinc SulphateN/ASide Effects of Zinc SulphateN/AContra-indications of Zinc SulphateN/ASpecial Precautions while taking Zinc SulphateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Zinc SulphateN/AInteractions for Zinc SulphateN/ATypical Dosage for Zinc SulphateN/ASchedule of Zinc SulphateN/AStorage Requirements for Zinc SulphateN/AEffects of Missed Dosage of Zinc SulphateN/AEffects of Overdose of Zinc SulphateN/AHome Delivery for Betamethasone Dipropionate + Zinc Sulphate in Your City
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