Vitamin B Complex + L-Methionine + Choline + Vitamin E Pharmacology

Vitamin B Complex + L-Methionine + Choline + Vitamin E

About Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Mechanism of Action of Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Pharmacokinets of Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Onset of Action for Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Duration of Action for Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Half Life of Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Side Effects of Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Contra-indications of Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Special Precautions while taking Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Vitamin B Complex + L-Methionine + Choline + Vitamin E
Nutritional supplement
Interactions for Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Typical Dosage for Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Schedule of Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Storage Requirements for Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Effects of Missed Dosage of Vitamin B Complex + L-Methionine + Choline + Vitamin E
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Effects of Overdose of Vitamin B Complex + L-Methionine + Choline + Vitamin E
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About
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Mechanism of Action of
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Duration of Action for
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Half Life of
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Side Effects of
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Contra-indications of
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Special Precautions while taking
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for
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Interactions for
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Typical Dosage for
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Schedule of
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Storage Requirements for
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Effects of Missed Dosage of
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Effects of Overdose of
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L-Methionine

About L-Methionine
Sulfur-containing essential amino acid,powerful antioxidant.
Mechanism of Action of L-Methionine
Due to methionine's sulfurous properties, it may help to reduce cholesterol and liver fat, protect the kidneys, reduce bladder irritation, and detoxify both metabolic wastes and toxins. The naturally occurring sulfur found in methionine supplements may encourage healthy hair follicles, skin and nails.
Pharmacokinets of L-Methionine
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Onset of Action for L-Methionine
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Duration of Action for L-Methionine
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Half Life of L-Methionine
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Side Effects of L-Methionine
1.Nausea
2.Vomiting
3.Drowsiness
4.Irritability
Contra-indications of L-Methionine
Methylenetetrahydrofolate reductase deficiency
Special Precautions while taking L-Methionine
1.Methionine supplementation should only be taken with adequate amounts of B vitamins, supplied either through the diet or through a B-complex supplement. Methionine increases the liver's production of homocysteine, and the B vitamins are needed to prevent the homocysteine from entering the blood. This would be a problem because high blood homocysteine levels have been associated with an increased risk for cardiovascular disease.
2.Liver disease
3.Acidosis
4.Homocystinuria
5.Schizophrenia: Large doses of methionine (e.g., 20 g/day for 5 days) might cause confusion, disorientation, delirium, agitation, listlessness, and other similar symptoms in people with schizophrenia.
6.Atherosclerosis: There is some concern that methionine might make atherosclerosis worse
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for L-Methionine
1.Nutritional supplement
2.Preventing liver damage in cases of acetaminophen poisoning when given by mouth or intravenously.Treatment should begin as quickly as possible, but must start within 10 hours of acetaminophen overdose.
Interactions for L-Methionine
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Typical Dosage for L-Methionine
The recommended dosage of methionine is between 800 and 1,000 mg per day for adults and from 1,600 to 2,000 mg a day for children.
Schedule of L-Methionine
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Storage Requirements for L-Methionine
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Effects of Missed Dosage of L-Methionine
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Effects of Overdose of L-Methionine
Much methionine can cause brain damage and death. Methionine can increase blood levels of homocysteine, a chemical that might cause heart disease. Methionine might also promote the growth of some tumors.

Choline

About Choline
A water-soluble essential nutrient, natural quaternary saturated amine.
Mechanism of Action of Choline
Choline is a water-soluble vitamin. Choline aids in nerve transmission and utilization of fat and hormone production. It also maintain normal kidney and bladder function.
It is most effective with Vitamin A, B-Complex, B-12, Folic Acid, and Inositol. Also, it helps lower cholesterol, transferring nerve impulse to the brain, helps against memory loss and senile dementia, and aids the liver in removing poisons and drugs from the bloodstream.
Pharmacokinets of Choline
Absorption: Choline is readily absorbed throughout the small intestine.
Onset of Action for Choline
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Duration of Action for Choline
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Half Life of Choline
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Side Effects of Choline
1.Breathing problems
2.Chest pain
3.Skin hives
4.Rash
5.Upset stomach
Contra-indications of Choline
Hypersensitivity to Choline
Special Precautions while taking Choline
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Choline
1.Headache
2.Head injury
3.Hemiplegia
4.Memory loss
5.Neurological dysfunction
6.Seizure
7.Stroke
8.Tardive dyskinesia
Interactions for Choline
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Typical Dosage for Choline
300mg, 3 times a day.
Schedule of Choline
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Storage Requirements for Choline
Store in cool (<30 degree C) and dark place
Effects of Missed Dosage of Choline
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Choline
Give symptomatic and supportive treatment

Vitamin E

About Vitamin E
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Mechanism of Action of Vitamin E
Vitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation.
Pharmacokinets of Vitamin E
Absorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases.
Distribution: Widely distributed in a protein bound form and stored in adipose tissue.
Metabolism: Metabolized in liver by glucuronide conjugation.
Excretion: Excreted mainly through bile and also excreted through urine.
Onset of Action for Vitamin E
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Duration of Action for Vitamin E
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Half Life of Vitamin E
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Side Effects of Vitamin E
1. Fatigue
2. Weakness
3. Headache
4. Nausea
5. Diarrhoea
6. Blurred vision
7. Flatulence


Contra-indications of Vitamin E
1. Hypersensitivity to the drug
2. Should not administer intravenously
Special Precautions while taking Vitamin E
1. Hepatic impairment
2. Gall bladder disease
3. Along with estrogens
Pregnancy Related Information
May be used
Old Age Related Information
N/A
Breast Feeding Related Information
May be used
Children Related Information
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Indications for Vitamin E
1. Vitamin E deficiency
2. Intermittent claudication
3. Nocturnal muscle cramps
4. Coronary artery disease
5. Fibrocystic breast disease
6. Cystic fibrosis
7. In premature infants exposed to high concentration of oxygen
8. As antioxidant


Interactions for Vitamin E
Oral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.

Typical Dosage for Vitamin E
Oral:
Vitamin E deficiency:
Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency.
Children: 1 unit/kg/day.
Premature neonates: 5units daily.
Full term neonates: 5 units per liter of formula.
Intermittent claudication: 400mg/day for 12 to 18 weeks.
Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks.
Coronary artery disease: 100 to 200mg/day for at least 2 years.
Fibrocystic breast disease: 600mg/day for at least 2years.
Cystic fibrosis: 100 to 200mg/day.
Children above 1 year: 100mg/day.
Children below 1year: 50mg/day.



Schedule of Vitamin E
C1
Storage Requirements for Vitamin E
Store in a well closed container in a cool dry place. Protect from light.
Effects of Missed Dosage of Vitamin E
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vitamin E
Provide supportive measures and symptomatic treatment.

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