Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid Pharmacology

Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

About Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Mechanism of Action of Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Pharmacokinets of Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Onset of Action for Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Duration of Action for Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Half Life of Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Side Effects of Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Contra-indications of Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Special Precautions while taking Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Pregnancy Related Information

Use with caution

Old Age Related Information

N/A

Breast Feeding Related Information

Use with caution

Children Related Information

N/A

Indications for Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

1.Diabetic neuropathy
2.Nutritional supplement

Interactions for Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Typical Dosage for Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Schedule of Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Storage Requirements for Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Effects of Missed Dosage of Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Effects of Overdose of Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid

N/A

Alpha-Lipoic acid

About Alpha-Lipoic acid

Naturally occurring dithiol compound , antioxidant, Agent for neuropathies.

Mechanism of Action of Alpha-Lipoic acid

Alpha-lipoic acid and its reduced metabolite, Dihydrolipoic acid (DHLA), form a redox couple and may scavenge a wide range of reactive oxygen species. Alpha-lipoic acid has been found to decrease urinary isoprostanes, O-LDL and plasma protein carbonyls, markers of oxidative stress. Further, alpha-lipoic acid and its redox couple DHLA have been found to have antioxidant activity in aqueous, as well as in lipophilic regions, and in extra cellular and intracellular environments. Alpha-lipoic acid participates in the recycling of other important biologic antioxidants, such as vitamins E and C, Ubiquinone and glutathione.
Both alpha-lipoic acid and DHLA can scavenge hydroxyl radicals, the nitric oxide radical, peroxynitrite, hydrogen peroxide and hypochlorite. Alpha-lipoic acid may scavenge singlet oxygen, and DHLA may scavenge super oxide and peroxyl reactive oxygen species.

Pharmacokinets of Alpha-Lipoic acid

Absorption: Alpha-lipoic acid is absorbed from the small intestine. The natural R-entantiomer is more readily absorbed than the L-entantiomer and is the more active form.
Distribution:It is distributed to the liver via the portal circulation and to various tissues in the body via the systemic circulation. . Alpha-lipoic acid readily crosses the blood-brain barrier. It is found, after its distribution to the various body tissues, intracellularly, intramitochondrialy and extracellularly.Metabolism: Alpha-lipoic acid is metabolized to its reduced form, dihydrolipoic acid (DHLA), by mitochondrial lipoamide dehydrogenase enzyme. DHLA, together with lipoic acid, form a redox couple. It is also metabolized to lipoamide, which functions as the lipoic acid cofactor in the multienzyme complexes that catalyze the oxidative decarboxylations of pyruvate and alpha-ketoglutarate. Alpha-lipoic acid may be metabolized to dithiol octanoic acid, which can undergo catabolism.

Onset of Action for Alpha-Lipoic acid

N/A

Duration of Action for Alpha-Lipoic acid

N/A

Half Life of Alpha-Lipoic acid

N/A

Side Effects of Alpha-Lipoic acid

1.Nausea
2.Vomiting

Contra-indications of Alpha-Lipoic acid

1.Contraindicated during radiotherapy

Special Precautions while taking Alpha-Lipoic acid

Patient with diabetes and problems with glucose intolerance

Pregnancy Related Information

Use with caution

Old Age Related Information

N/A

Breast Feeding Related Information

Use with caution

Children Related Information

N/A

Indications for Alpha-Lipoic acid

1.Diabetic neuropathy
2.It may help prevent the oxidation of LDL cholesterol and may be protective, generally, against oxidative stress and, specifically, against atherosclerosis, ischemia-reperfusion injury and various radiologic and chemical toxins.
3.It may also be useful in some inborn metabolic disorders

Interactions for Alpha-Lipoic acid

N/A

Typical Dosage for Alpha-Lipoic acid

Adult: up to 600 milligrams daily
Diabetic neuropathy: 300 milligrams daily taken in divided doses.

Schedule of Alpha-Lipoic acid

N/A

Storage Requirements for Alpha-Lipoic acid

Store at room temperature away from moisture and heat.Keep out of the reach of children. Keep the medicine from freezing. Do not refrigerate.

Effects of Missed Dosage of Alpha-Lipoic acid

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.

Effects of Overdose of Alpha-Lipoic acid

Give supportive measures and symptomatic treatment.

Mecobalamin

About Mecobalamin

Water soluble, Form of Vitamin B12

Mechanism of Action of Mecobalamin

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Pharmacokinets of Mecobalamin

Absorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine

Onset of Action for Mecobalamin

N/A

Duration of Action for Mecobalamin

N/A

Half Life of Mecobalamin

N/A

Side Effects of Mecobalamin

1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site

Contra-indications of Mecobalamin

N/A

Special Precautions while taking Mecobalamin

N/A

Pregnancy Related Information

May be used

Old Age Related Information

May be used

Breast Feeding Related Information

May be used

Children Related Information

N/A

Indications for Mecobalamin

1.Peripheral neuropathies
2.Megaloblastic anaemia

Interactions for Mecobalamin

1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol

Typical Dosage for Mecobalamin

Peripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk

Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.

Schedule of Mecobalamin

N/A

Storage Requirements for Mecobalamin

Oral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.

Effects of Missed Dosage of Mecobalamin

N/A

Effects of Overdose of Mecobalamin

N/A

Gamma linolenic acid

About Gamma linolenic acid

An essential Fatty acid(omega-6 family), A dietary supplement with antiinflammatory.

Mechanism of Action of Gamma linolenic acid

GLA is metabolized to the 20-carbon polyunsaturated fatty acid DGLA, which is cyclooxygenated to prostaglandin E1 (PGE1). PGE1 elicits biologic activities by binding to surface receptors on smooth muscle cells, increasing intracellular cAMP.
GLA, via conversion to PGE1, exhibits anti-inflammatory, antithrombotic, antiproliferative, and lipid-lowering potential. It also enhances smooth muscle relaxation and vasodilation. In addition, EFAs including GLA are important constituents of membrane phospholipids, including the mitochondrial membrane, where they enhance the integrity and the fluidity of the membrane. Studies have shown that GLA has a role in management of Dry eye, Atopic eczema and cyclical mastalgia (pre-menstrual breast pain).

Pharmacokinets of Gamma linolenic acid

N/A

Onset of Action for Gamma linolenic acid

N/A

Duration of Action for Gamma linolenic acid

N/A

Half Life of Gamma linolenic acid

N/A

Side Effects of Gamma linolenic acid

1.Upset stomach
2.Diarrhea
3.Soft stool
4.Bloating
5.Gas

Contra-indications of Gamma linolenic acid

N/A

Special Precautions while taking Gamma linolenic acid

N/A

Pregnancy Related Information

N/A

Old Age Related Information

N/A

Breast Feeding Related Information

N/A

Children Related Information

N/A

Indications for Gamma linolenic acid

N/A

Interactions for Gamma linolenic acid

1.Phenothiazines and anticonvulsants due to an increased incidence of seizures.
2.Even though no cases are known of interaction with anticoagulant medications, it may be prudent to closely monitor concomitant usage.
3.Gamma Linolenic acid is shown to reduce tremors from lithium use in manic depressives.

Typical Dosage for Gamma linolenic acid

N/A

Schedule of Gamma linolenic acid

N/A

Storage Requirements for Gamma linolenic acid

N/A

Effects of Missed Dosage of Gamma linolenic acid

N/A

Effects of Overdose of Gamma linolenic acid

N/A

Benfotiamine

About Benfotiamine

Synthetic S-acyl derivative of thiamine (vitamine B1), Antioxidant ,anti-AGE(Advanced glycation end product) supplement, Treating Diabetic Complications.

Mechanism of Action of Benfotiamine

N/A

Pharmacokinets of Benfotiamine

N/A

Onset of Action for Benfotiamine

N/A

Duration of Action for Benfotiamine

N/A

Half Life of Benfotiamine

N/A

Side Effects of Benfotiamine

N/A

Contra-indications of Benfotiamine

N/A

Special Precautions while taking Benfotiamine

N/A

Pregnancy Related Information

N/A

Old Age Related Information

N/A

Breast Feeding Related Information

N/A

Children Related Information

N/A

Indications for Benfotiamine

1.Management of diabetic neuropathy, diabetic nephropathy and diabetic retinopathy
2.Beri Beri
3.Wenicke-korsakoff syndrome

Interactions for Benfotiamine

N/A

Typical Dosage for Benfotiamine

N/A

Schedule of Benfotiamine

N/A

Storage Requirements for Benfotiamine

N/A

Effects of Missed Dosage of Benfotiamine

N/A

Effects of Overdose of Benfotiamine

N/A

Pyridoxine

About Pyridoxine

Water soluble vitamin(Vit B6), In Vitamin B6 deficiency ,Neuropathy.

Mechanism of Action of Pyridoxine

N/A

Pharmacokinets of Pyridoxine

N/A

Onset of Action for Pyridoxine

N/A

Duration of Action for Pyridoxine

N/A

Half Life of Pyridoxine

N/A

Side Effects of Pyridoxine

N/A

Contra-indications of Pyridoxine

N/A

Special Precautions while taking Pyridoxine

N/A

Pregnancy Related Information

N/A

Old Age Related Information

N/A

Breast Feeding Related Information

N/A

Children Related Information

N/A

Indications for Pyridoxine

N/A

Interactions for Pyridoxine

N/A

Typical Dosage for Pyridoxine

N/A

Schedule of Pyridoxine

N/A

Storage Requirements for Pyridoxine

N/A

Effects of Missed Dosage of Pyridoxine

N/A

Effects of Overdose of Pyridoxine

N/A

Folic Acid

About Folic Acid

Dietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.

Mechanism of Action of Folic Acid

Folic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.

Pharmacokinets of Folic Acid

Absorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.

Onset of Action for Folic Acid

Oral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes

Duration of Action for Folic Acid

Oral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours

Half Life of Folic Acid

N/A

Side Effects of Folic Acid

N/A

Contra-indications of Folic Acid

N/A

Special Precautions while taking Folic Acid

1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient

Pregnancy Related Information

May be used

Old Age Related Information

May be used

Breast Feeding Related Information

May be used

Children Related Information

May be used

Indications for Folic Acid

1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue

Interactions for Folic Acid

1. Hypersensitivity reactions with injection form
2. Bronchospasm

Typical Dosage for Folic Acid

Oral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.

Schedule of Folic Acid

C1 (Oral)
C (Parenteral)

Storage Requirements for Folic Acid

Store at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.

Effects of Missed Dosage of Folic Acid

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Folic Acid

Relatively non toxic. Provide symptomatic treatment and supportive measures.

Home Delivery for Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including alpha-lipoic acid + mecobalamin +gamma linolenic acid + benfotiamine + pyridoxine + folic acid.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for alpha-lipoic acid + mecobalamin +gamma linolenic acid + benfotiamine + pyridoxine + folic acid and other medicines and health products. Home delivery services for alpha-lipoic acid + mecobalamin +gamma linolenic acid + benfotiamine + pyridoxine + folic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take alpha-lipoic acid + mecobalamin +gamma linolenic acid + benfotiamine + pyridoxine + folic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for alpha-lipoic acid + mecobalamin +gamma linolenic acid + benfotiamine + pyridoxine + folic acid before they complete the sale. You can get this information while placing the order for alpha-lipoic acid + mecobalamin +gamma linolenic acid + benfotiamine + pyridoxine + folic acid with the pharmacy.

Alpha-lipoic acid + Mecobalamin +Gamma linolenic acid + Benfotiamine + Pyridoxine + Folic acid is a generic medicine name and there are several brands available for it. Some of the brands for alpha-lipoic acid + mecobalamin +gamma linolenic acid + benfotiamine + pyridoxine + folic acid might be better known than alpha-lipoic acid + mecobalamin +gamma linolenic acid + benfotiamine + pyridoxine + folic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have alpha-lipoic acid + mecobalamin +gamma linolenic acid + benfotiamine + pyridoxine + folic acid in stock, you can ask for one of the branded alternatives for alpha-lipoic acid + mecobalamin +gamma linolenic acid + benfotiamine + pyridoxine + folic acid.