Adefovir Pharmacology

Adefovir

About Adefovir

Antiretroviral Agent, Reverse Transcriptase Inhibitor (Nucleoside)

Mechanism of Action of Adefovir

Adefovir undergoes phosphorylation in the presence of cellular kinase enzyme to Adefovir diphosphate. This Adefovir diphosphate competitively inhibits HBV DNA polymerase and reverse transcriptase enzyme by competing with nucleoside adenosine triphosphate and inhibits DNA synthesis.

Pharmacokinets of Adefovir

Absorption: It is absorbed after oral administration. Distribution: It is distributed in the body. Excretion: It is excreted mainly through urine.

Onset of Action for Adefovir

N/A

Duration of Action for Adefovir

N/A

Half Life of Adefovir

8 hour

Side Effects of Adefovir

1.Asthenia
2.Headache
3.Nausea
4.Diarrhoea
5.Abdominal pain
6.Flatulance
7.Dyspepsia
8.Fever
9.Rash
10.Increase in liver enzyme

Contra-indications of Adefovir

Hypersensitivity to Adefovir

Special Precautions while taking Adefovir

1.Renal impairment
2.Hepatic impairment

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated
NEONATES: contraindicated

Indications for Adefovir

1.Hepatitis B infection

Interactions for Adefovir

N/A

Typical Dosage for Adefovir

Adult: 10 mg / day

Schedule of Adefovir

Storage Requirements for Adefovir

The drug should be kept at 15 - 30 degree C in a tightly closed container. Protect away from heat and light. Keep out of the reach of children.

Effects of Missed Dosage of Adefovir

Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.

Effects of Overdose of Adefovir

Give supportive measures and treatment

Home Delivery for Adefovir in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including adefovir.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for adefovir and other medicines and health products. Home delivery services for adefovir may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take adefovir only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for adefovir before they complete the sale. You can get this information while placing the order for adefovir with the pharmacy.

Adefovir is a generic medicine name and there are several brands available for it. Some of the brands for adefovir might be better known than adefovir itself. If the pharmacy that's willing to deliver medicines to your home doesn't have adefovir in stock, you can ask for one of the branded alternatives for adefovir.