Dextran Pharmacology

Dextran

About Dextran
A group of long-chain Polysaccharides composed of glucose,Intravenous fluids, Plasma expanders (((substitutes for whole blood))) in severe shock.
Mechanism of Action of Dextran
Dextran is a plasma volume expander which reduces blood viscosity. It forms a coating on RBC and maintains their electronegative charge and prevents RBC sludging that occurs in shock. It improves microcirculation. They are both osmotically active, and too large to pass through the uninjured vessel wall. They possess antiplatelet and anti-fibrin activities. They bind to platelets, RBCs, and the lining of the vessel wall decreasing their ability to stick together and forming clots.
Pharmacokinets of Dextran
Absorption: Administered intravenously, Metabolism: Partially oxidized in the body, Excretion: Excreted through urine.
Onset of Action for Dextran
N/A
Duration of Action for Dextran
N/A
Half Life of Dextran
N/A
Side Effects of Dextran
1.Urticaria
2.Itching
3.Fever
4.Joint pain
5.Stomach pain
6.Nausea
7.Vomiting
8.Bronchospasm
9.Fall in BP
10.Pain and burning sensation at the injection site
11.Allergic reactions
12.Rashes
13.Stuffy nose
14.Tightness in the chest
15.Wheezing
16.Unusual swelling
17.Difficulty in passing urine
Contra-indications of Dextran
1.Hypersensitivity to Dextran
2.Hypofibrinogenemia
3.Thrombocytopenia
4.Haemorrhage.
Special Precautions while taking Dextran
Use with caution in following conditions:
1.Closely monitor patient condition and vital parameters during Dextran administration 2.Bleeding disorders
3.Dehydration
4.Cardiac diseases
5.Renal impairment
6.Pulmonary oedema
7.Low sodium diet.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Dextran
1.Shock
2.Foetal distress syndrome
3.Cerebrovascular accident
4.Prevention of peritoneal adhesions.
Interactions for Dextran
N/A
Typical Dosage for Dextran
I.V.: Dosage individualized based on patient`s requirements. Total dose should not exceed 20ml/kg/24 hours.
After micro vascular transplantation:
Adults: 25cc/hour postoperatively for five days.
Children: 8-10 cc/kg/24hrs
Schedule of Dextran
C
Storage Requirements for Dextran
Store at a temperature range of 2 to 80C. Keep out of reach of children.
Effects of Missed Dosage of Dextran
N/A
Effects of Overdose of Dextran
Provide symptomatic treatment and supportive measures.

Home Delivery for Dextran in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dextran.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dextran and other medicines and health products. Home delivery services for dextran may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dextran only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dextran before they complete the sale. You can get this information while placing the order for dextran with the pharmacy.

Dextran is a generic medicine name and there are several brands available for it. Some of the brands for dextran might be better known than dextran itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextran in stock, you can ask for one of the branded alternatives for dextran.