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- Pharmacology For Erythrityl Tetranitrate
Erythrityl Tetranitrate Pharmacology
Erythrityl Tetranitrate
About Erythrityl TetranitrateN/AMechanism of Action of Erythrityl TetranitrateIt is a direct smooth muscle relaxant, which have a prominent action vascular smooth muscles preferentially veins than arteries. It is enzymatically denitrated in the smooth muscle cells to release the reactive free radical nitric oxide which activates cytosolic guanylyl cyclase thus increases cyclic GMP levels which causes dephosphorylation of myosin light chain kinase(MLCK) through a cyclic GMP dependent protein kinase. Reduced availability of phosphorylated (active) MLCK interferes with activation of myosin and myosin fails to interact with actin to cause contraction and consequently relaxation occurs. Elevated levels of cyclic GMP also reduce calcium entry which also contributing to relaxation. It dilates veins more than arteries because veins have greater amount of enzyme that generate nitric oxide from nitrates. It also preferentially dilates epicardial arteries than autoregulatory arteries duo to defferential distribution of nitrate metabolizing enzymes in these vessels.
It causes preload reduction, slight decrease in after load, and preferential relaxation of larger conducting coronary arteries and is used as an effective drug in the treatment of angina.
Pharmacokinets of Erythrityl TetranitrateAbsorption: Well absorbed orallyOnset of Action for Erythrityl TetranitrateSublingual: Within 5 minutes
Oral: 15 to 30 minutes
Duration of Action for Erythrityl Tetranitrate4 to 6 hoursHalf Life of Erythrityl TetranitrateN/ASide Effects of Erythrityl Tetranitrate1. Headache
2. Weakness
3. Dizziness
4. Methaemoglobinaemia
5. Flushing
6. Palpitation
7. Rashes
Contra-indications of Erythrityl Tetranitrate1. Myocardial infarction
2. Hypersensitivity to nitrates
Special Precautions while taking Erythrityl Tetranitrate1. Gradually withdraw the drug with caution
2. Postural hypotension
3. Cerebro vascular haemorrhage
4. Glaucoma
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Erythrityl Tetranitrate1. Classical angina
2. Variant angina
Interactions for Erythrityl TetranitrateAlcohol : Severe hypotension and cardiovascular collapse.
Aspirin : Increase serum concentrations of nitrates and their actions.
Antihypertensives, TCAs, Phenothiazines, Calcium channel blockers : Marked symptomatic orthostatic hypotension.
Lab Tests : May interfere with the Zlatkis-Zak colour reaction causing a false report of decreased serum cholesterol.Typical Dosage for Erythrityl Tetranitrate5mg sublingually or 10mg orally thrice daily. Increased to 15mg; three to four
times daily.
Schedule of Erythrityl TetranitrateHStorage Requirements for Erythrityl TetranitrateStore in a tightly closed container away from flame and heat and protects from moisture.Effects of Missed Dosage of Erythrityl TetranitrateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Erythrityl TetranitrateTreatment is supportive and symptomatic. Remove drug from the body by gastric lavage and administer activated charcoal to reduce absorption. Monitor blood gas measurements and methemoglobin levels. Supportive measures include respiratory support and oxygen administration. Recumbent positioning and passive movements of the extremities aid venous return.Home Delivery for Erythrityl Tetranitrate in Your City
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Please be aware that you should take erythrityl tetranitrate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for erythrityl tetranitrate before they complete the sale. You can get this information while placing the order for erythrityl tetranitrate with the pharmacy.
Erythrityl Tetranitrate is a generic medicine name and there are several brands available for it. Some of the brands for erythrityl tetranitrate might be better known than erythrityl tetranitrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have erythrityl tetranitrate in stock, you can ask for one of the branded alternatives for erythrityl tetranitrate.