Erythrityl Tetranitrate Pharmacology

Erythrityl Tetranitrate

About Erythrityl Tetranitrate
N/A
Mechanism of Action of Erythrityl Tetranitrate
It is a direct smooth muscle relaxant, which have a prominent action vascular smooth muscles preferentially veins than arteries. It is enzymatically denitrated in the smooth muscle cells to release the reactive free radical nitric oxide which activates cytosolic guanylyl cyclase thus increases cyclic GMP levels which causes dephosphorylation of myosin light chain kinase(MLCK) through a cyclic GMP dependent protein kinase. Reduced availability of phosphorylated (active) MLCK interferes with activation of myosin and myosin fails to interact with actin to cause contraction and consequently relaxation occurs. Elevated levels of cyclic GMP also reduce calcium entry which also contributing to relaxation. It dilates veins more than arteries because veins have greater amount of enzyme that generate nitric oxide from nitrates. It also preferentially dilates epicardial arteries than autoregulatory arteries duo to defferential distribution of nitrate metabolizing enzymes in these vessels.
It causes preload reduction, slight decrease in after load, and preferential relaxation of larger conducting coronary arteries and is used as an effective drug in the treatment of angina.

Pharmacokinets of Erythrityl Tetranitrate
Absorption: Well absorbed orally
Onset of Action for Erythrityl Tetranitrate
Sublingual: Within 5 minutes
Oral: 15 to 30 minutes
Duration of Action for Erythrityl Tetranitrate
4 to 6 hours
Half Life of Erythrityl Tetranitrate
N/A
Side Effects of Erythrityl Tetranitrate
1. Headache
2. Weakness
3. Dizziness
4. Methaemoglobinaemia
5. Flushing
6. Palpitation
7. Rashes

Contra-indications of Erythrityl Tetranitrate
1. Myocardial infarction
2. Hypersensitivity to nitrates
Special Precautions while taking Erythrityl Tetranitrate
1. Gradually withdraw the drug with caution
2. Postural hypotension
3. Cerebro vascular haemorrhage
4. Glaucoma


Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
Indications for Erythrityl Tetranitrate
1. Classical angina
2. Variant angina

Interactions for Erythrityl Tetranitrate
Alcohol : Severe hypotension and cardiovascular collapse.
Aspirin : Increase serum concentrations of nitrates and their actions.
Antihypertensives, TCAs, Phenothiazines, Calcium channel blockers : Marked symptomatic orthostatic hypotension.
Lab Tests : May interfere with the Zlatkis-Zak colour reaction causing a false report of decreased serum cholesterol.
Typical Dosage for Erythrityl Tetranitrate
5mg sublingually or 10mg orally thrice daily. Increased to 15mg; three to four
times daily.
Schedule of Erythrityl Tetranitrate
H
Storage Requirements for Erythrityl Tetranitrate
Store in a tightly closed container away from flame and heat and protects from moisture.
Effects of Missed Dosage of Erythrityl Tetranitrate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Erythrityl Tetranitrate
Treatment is supportive and symptomatic. Remove drug from the body by gastric lavage and administer activated charcoal to reduce absorption. Monitor blood gas measurements and methemoglobin levels. Supportive measures include respiratory support and oxygen administration. Recumbent positioning and passive movements of the extremities aid venous return.

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Erythrityl Tetranitrate is a generic medicine name and there are several brands available for it. Some of the brands for erythrityl tetranitrate might be better known than erythrityl tetranitrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have erythrityl tetranitrate in stock, you can ask for one of the branded alternatives for erythrityl tetranitrate.