Amoxapine Pharmacology

Amoxapine

About Amoxapine
Dibenzoxazepine class, Anti depressent.
Mechanism of Action of Amoxapine
Amoxapine acts by inhibiting the re-uptake of Noradrenaline, and Serotonin (5 HT) in the CNS nerve terminals .This will result in an increased concentration of neurotransmitters in the synaptic cleft and produces antidepressant effect. Amoxapine also blocks the response of Dopamine receptor to Dopamine.8-Hydroxyamoxapine; the metabolite of Amoxapine more selectively inhibits the reuptake of Serotonin than Noradrenaline. 7-Hydroxyamoxapine has Dopamine receptor blocking activity.
Pharmacokinets of Amoxapine
Absorption: Amoxapine is rapidly absorbed after oral administration. Distribution: It is widely distributed in the body in protein bound form Metabolism: Amoxapine is metabolised in the liver to active metabolites 8-Hydroxyamoxapine and 7-Hydroxyamoxapine. Excretion: Drug is excreted mainly through urine. Some is excreted through faeces also.

Onset of Action for Amoxapine
2 days
Duration of Action for Amoxapine
4 - 7 days
Half Life of Amoxapine
8 - 30 hours
Side Effects of Amoxapine
1. Drowsiness
2 Dizziness
3. Nausea
4. Vomiting
5. Blurred vision
6. Difficulty in micturition
7. Tachycardia
8. Hypotension
10. Dryness of mouth
11. Constipation
12. Confusion
13. Headache
14. Sedation
15. Blood dyscrasias
16. Tardive dyskinesia
17. Rash
18. Jaundice
19. Anorexia
20. Impotence
21. Loss of libido
22. Galactorrhea
23. Gynecomastia
Contra-indications of Amoxapine
1. Hypersensitivity to Amoxapine
2. Myocardial infarction
3. Severe liver disease

Special Precautions while taking Amoxapine
1.Renal impairment
2.Hepatic impairment
3.Cardiac arrhythmia
4.Myocardial infarction
5.Tachycardia
6.Heart failure
7.Strokes
8.Angle closure glaucoma
9.History of urine retention
10.Hyperthyroidism
11.Epilepsy
12. Alcoholics
13.Slowly withdraw the drug with caution
14.Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment.
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated

Indications for Amoxapine
1.Depression
2.Obsessive compulsive disorder
Interactions for Amoxapine
Anticholinergics: Enhanced effect of anticholinergics may occur.
Barbiturates: Serum level of imipramine decreased; additive respiratory depressant effect.
Clonidine: Hypertensive crisis.
Dicoumarol: Increase in anticoagulation effects.
Disulfiram: Acute organic brain syndrome.
Fluoxetine & Haloperidol: Potentiate action of Amoxapine.
Levodopa: Its bioavailability is reduced, hypertensive episodes.
MAOIs Furazolidone: Seizures, sweating , coma, hyperexcitability, hyperthermia, tachycardia, mydriasis, confusion, DIC (Disseminated Intravascular Coagulation) and death.
Oral contraceptives and phenothiazines: Increase plasma levels of Amoxapine.
Smoking: Increases metabolic bio-transformation.
Alcohol: Sedative effective of alcohol potentiated.
Typical Dosage for Amoxapine
Adult:
Initial dose: 100- 150 mg / day at night or in 2 -3 divided doses. Dose can be gradually increases up to 300 mg / day in 2 - 3 divided doses.
Maintenance dose: 150 - 250 mg / day in 2 - 3 divided doses or as single dose at night.
Maximum dose: 600 mg / day
Schedule of Amoxapine
H
Storage Requirements for Amoxapine
Store in a cool place in a tightly closed container. Keep out of the reach of children.
Effects of Missed Dosage of Amoxapine
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Amoxapine
Give supportive measures and treatment. Remove the drug from the body by inducing emesis and by gastric lavage. Charcoal is given to reduce the absorption of the drug. Seizure can be treated with Diazepam or Phenytoin, arrhythmia with Lidocaine and acidosis with Sodium bicarbonate.

Home Delivery for Amoxapine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including amoxapine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for amoxapine and other medicines and health products. Home delivery services for amoxapine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take amoxapine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for amoxapine before they complete the sale. You can get this information while placing the order for amoxapine with the pharmacy.

Amoxapine is a generic medicine name and there are several brands available for it. Some of the brands for amoxapine might be better known than amoxapine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have amoxapine in stock, you can ask for one of the branded alternatives for amoxapine.