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- Pharmacology For Meclizine + Vit B6
Meclizine + Vit B6 Pharmacology
Meclizine + Vit B6
About Meclizine + Vit B6N/AMechanism of Action of Meclizine + Vit B6N/APharmacokinets of Meclizine + Vit B6N/AOnset of Action for Meclizine + Vit B6N/ADuration of Action for Meclizine + Vit B6N/AHalf Life of Meclizine + Vit B6N/ASide Effects of Meclizine + Vit B6N/AContra-indications of Meclizine + Vit B6N/ASpecial Precautions while taking Meclizine + Vit B6N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Meclizine + Vit B6N/AInteractions for Meclizine + Vit B6N/ATypical Dosage for Meclizine + Vit B6N/ASchedule of Meclizine + Vit B6N/AStorage Requirements for Meclizine + Vit B6N/AEffects of Missed Dosage of Meclizine + Vit B6N/AEffects of Overdose of Meclizine + Vit B6N/AMeclizine
About MeclizineFirst Generation H1 Antagonist, Piperazine derivative, Antihistamine, antiemetic, antinauseant.Mechanism of Action of MeclizineMeclizine produces Antiemetic action by its central action on Chemoreceptor trigger zone (CTZ). It decreases the sensitivity of Labyrinth apparatus which transmit stimuli to the CTZ and stimulates the vomiting center.
Meclizine produces antivertigo action by decreasing the excitability of middle ear labyrinth. It blocks the conduction in the middle ear vestibular path ways.
Meclizine is a potent H1 receptor antihistaminic agent. It has anticholinergic activity also
Pharmacokinets of MeclizineAbsorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body. Metabolism: It is metabolised in the liver. Excretion: Drug is excreted in faeces and also in urine.Onset of Action for Meclizine1 hourDuration of Action for Meclizine8 - 24 hoursHalf Life of Meclizine6 hoursSide Effects of Meclizine1.Drowsiness
2.Dry mouth
3.Restlessness
4.Urine retention
5.Blurred vision
6.Constipation
7.Abdominal discomfort
Contra-indications of Meclizine1.Hypersensitivity to MeclizineSpecial Precautions while taking Meclizine1.Glaucoma
2.Asthma
3.Prostate hypertrophy
4.Alcoholics
5.Patient should be cautioned about driving vehicle or operating machines
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationUse with caution
CHILDREN below12 years: contraindicated
NEONATES: contraindicated
Indications for Meclizine1.Dizziness
2.Motion sickness
3.Vertigo
Interactions for MeclizineN/ATypical Dosage for MeclizineAdult:
Dizziness: 25 - 100 mg in 3 divided doses
Motion sickness: 25 - 50 mg to be taken 1 hour before beginning the travel and repeat the dose if necessary depending on the duration of journey
Children above 12 years:
Dizziness: 25 - 100 mg in 3 divided doses
Motion sickness: 25 - 50 mg to be taken 1 hour before beginning the travel and repeat the dose if necessary depending on the duration of journey
Schedule of MeclizineGStorage Requirements for MeclizineStore the drug at room temperature in a tightly closed container. Protect from heat and light.Effects of Missed Dosage of MeclizineTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MeclizineGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage. Hypotension can be treated with vasopressors and seizure with Diazepam or Phenytoin.Vit B6
About Vit B6Physiological functions: It is involved as a coenzyme (Pyridoxal phosphate) in metabolism of tryptophan, in several metabolic transformations of amino acids including transamination, decarboxylation & racemization.
Deficiency symptoms: Peripheral neuritis, seizures, stomatitis, glossitis, anaemia, seborrhea like lesions.Mechanism of Action of Vit B6Vitamin B6 is a collective term for Pyridoxine, Pyridoxal, Pyridoxamine and their phosphorylated derivatives such as Pyridoxine phosphate, Pyridoxal phosphate and Pyridoxamine derivatives respectively. Vitamin B6 is essential for the metabolism of amino acid, glycogen and fatty acids, for nerve functions, for the formation of red blood cells and also helps the skin healthy. Vitamin B6 is also used for the synthesis of nucleic acid, Haemoglobin, Sphingomyelin, other Sphingolipids, Serotonin, Dopamine, Noradrenaline and GABA.Pharmacokinets of Vit B6Absorption: Vitamin B6 is readily absorbed after oral administration.
Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain.
Metabolism: It is metabolised in the liver
Onset of Action for Vit B6N/ADuration of Action for Vit B6N/AHalf Life of Vit B615-20 daysSide Effects of Vit B61. Neuropathy
2. Unstable gait
3. Drowsiness
4. Perioral numbness
5. Paresthesia
6. Numbness of feet
7. Somnolence
8. Sensory neuropathy
9. Ataxia
Contra-indications of Vit B61. Hypersensitivity to Vitamin B6Special Precautions while taking Vit B6N/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Vit B61. Vitamin B6 deficiency including inadequate diet and drug induced causes
2. Neuropathy
3. Premenstrual syndrome
4. Hyperoxaluria type 1
5. Metabolic disorder
6. Isoniazid poisoning
Interactions for Vit B6Cycloserine, Hydralazine, Isoniazide, Oral contraceptive, Penicillamine: Increase Pyridoxine requirement.
Levodopa: Pyridoxine reverses the therapeutic effect of Levodopa.
Phenobarbital, Phenytoin: Pyridoxine decreases serum level of these anticonvulsants.
Typical Dosage for Vit B6Adult: 10 - 20 mg / day
Dietary deficiency: 2.5 -10 mg / day for effective therapeutic response is obtained.
Maintenance dose: 2 - 5 mg / day for several weeks.
Drug induced deficiency: 100 - 200 mg / day for 3 weeks.
Maintenance dose: 25 - 100 mg / day
Neuropathy: 50 - 200 mg /day
Premenstrual syndrome: 40 - 500 mg / day
Hyperoxaluria type 1: 25 - 300 mg / day
Metabolic disorder: 100-500 mg /day.
Isoniazid poisoning: Initial dose: 1 - 4 g as IV administration, then 1 g IM every 30 minute until Pyridoxine dose is equal to the Isoniazid dose has been given.
Schedule of Vit B6N/AStorage Requirements for Vit B6Store it at 15 - 30 degree C. Protect from moisture and heat.Effects of Missed Dosage of Vit B6Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B6Give supportive measures and symptomatic treatment. The signs of Pyridoxine overdose can be resolved by discontinuation (withdrawal) of Pyridoxine.Home Delivery for Meclizine + Vit B6 in Your City
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