Gabapentin Pharmacology

Gabapentin

About Gabapentin
A GABA analogue, Anticonvulsant, Mood stabilizer.
Mechanism of Action of Gabapentin
Gabapentin is a GABA derivative and it bounds to lipophilic molecule. The mechanism of action of Gabapentin is not exactly known. It crosses blood brain barrier and enhances release of GABA.
Pharmacokinets of Gabapentin
Absorption: It is not well absorbed after oral administration. The bioavailability is not dose dependent. Distribution: Gabapentin is distributed in the body in unbound form. Drug crosses blood brain barrier. Metabolism: Gabapentin undergoes insignificant metabolism. Excretion: Drug is excreted mainly in urine.
Onset of Action for Gabapentin
Within few weeks
Duration of Action for Gabapentin
6 - 8 hours
Half Life of Gabapentin
5 -8hours
Side Effects of Gabapentin
1.Dizziness
2.Somnolence
3.Tremor
4.Ataxia
5.Nausea
6.Vomiting
7.Convulsions
8.Dyspepsia
9.Headache
10.Fatigue
11.Diplopia
12.Nystagmus
13.Anorexia
14.Leukopenia
Contra-indications of Gabapentin
1.Hypersensitivity to Gabapentin
Special Precautions while taking Gabapentin
1.Renal impairment
2.Slowly withdraw the drug with caution
3.Use caution when driving vehicle, operating machine or performing other hazardous activities.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution.
NEONATES: contraindicated
Indications for Gabapentin
1.Antiepileptic(Treatment of partial seizure)
2.Treatment of neuropathic pain
Interactions for Gabapentin
N/A
Typical Dosage for Gabapentin
Adult: Initial dose: 300 mg / day increase the dose by 300 mg/day for next 2 days (up to 900 mg / day in 3 divided doses). Thereafter increase the dose until sufficient therapeutic response is obtained.
Maintenance dose: 900-1800mg /day in 3 divided doses
Maximum dose: 3.6 g /day
Children above 12 years: 10mg / kg / day in 3 divided doses, then gradually increase the dose until sufficient therapeutic response is obtained.

Schedule of Gabapentin
N/A
Storage Requirements for Gabapentin
Store at 15 - 30 degree C. Protect from heat and moisture.Store the Gabapentin solution at refrigerator.
Effects of Missed Dosage of Gabapentin
Take the missed dose as soon as noticed. If it the time for next dose then skips the missed dose and continue the regular schedule. Do not double the dose
Effects of Overdose of Gabapentin
Give supportive measures and symptomatic treatment. Haemodialysis can be done if needed

Home Delivery for Gabapentin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including gabapentin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for gabapentin and other medicines and health products. Home delivery services for gabapentin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take gabapentin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for gabapentin before they complete the sale. You can get this information while placing the order for gabapentin with the pharmacy.

Gabapentin is a generic medicine name and there are several brands available for it. Some of the brands for gabapentin might be better known than gabapentin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have gabapentin in stock, you can ask for one of the branded alternatives for gabapentin.