Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine Pharmacology

Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

About Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Mechanism of Action of Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Pharmacokinets of Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Onset of Action for Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Duration of Action for Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Half Life of Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Side Effects of Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Contra-indications of Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Special Precautions while taking Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Pregnancy Related Information

Contraindicated

Old Age Related Information

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Breast Feeding Related Information

Contraindicated

Children Related Information

N/A

Indications for Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

1.Cough
2.Nasal congestion
3.Cold

Interactions for Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

N/A

Typical Dosage for Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

Adult: 10 ml to be taken 3 times daily
Children: 5 ml to be taken 3 times daily
Children 2 - 6 years: 2.5 - 5 ml to be taken 3 times daily

Schedule of Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Storage Requirements for Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Effects of Missed Dosage of Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Effects of Overdose of Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine

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Dextromethorphan

About Dextromethorphan

A synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.

Mechanism of Action of Dextromethorphan

Dextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))

Pharmacokinets of Dextromethorphan

Absorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.

Onset of Action for Dextromethorphan

Below ? an hour

Duration of Action for Dextromethorphan

3 to 6 hours

Half Life of Dextromethorphan

11 hours

Side Effects of Dextromethorphan

1. Dizziness
2. Nausea
3. Vomiting
4. Stomach pain
5. Drowsiness
6. Ataxia.

Contra-indications of Dextromethorphan

Patients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.

Special Precautions while taking Dextromethorphan

1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin

Pregnancy Related Information

Contraindicated

Old Age Related Information

N/A

Breast Feeding Related Information

N/A

Children Related Information

May be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated

Indications for Dextromethorphan

Chronic nonproductive cough.

Interactions for Dextromethorphan

N/A

Typical Dosage for Dextromethorphan

Oral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.

Schedule of Dextromethorphan

N/A

Storage Requirements for Dextromethorphan

Store at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.

Effects of Missed Dosage of Dextromethorphan

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Dextromethorphan

Remove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.

Chlorpheniramine Maleate

About Chlorpheniramine Maleate

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Mechanism of Action of Chlorpheniramine Maleate

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Pharmacokinets of Chlorpheniramine Maleate

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Onset of Action for Chlorpheniramine Maleate

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Duration of Action for Chlorpheniramine Maleate

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Half Life of Chlorpheniramine Maleate

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Side Effects of Chlorpheniramine Maleate

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Contra-indications of Chlorpheniramine Maleate

First Generation alkylamine H1 Antagonist, Antihistamine.

Special Precautions while taking Chlorpheniramine Maleate

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Chlorpheniramine Maleate

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Interactions for Chlorpheniramine Maleate

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Typical Dosage for Chlorpheniramine Maleate

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Schedule of Chlorpheniramine Maleate

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Storage Requirements for Chlorpheniramine Maleate

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Effects of Missed Dosage of Chlorpheniramine Maleate

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Effects of Overdose of Chlorpheniramine Maleate

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Phenylephrine

About Phenylephrine

An a1-adrenergic receptor agonist, Phenethylamine derivative, Decongestant, Antiglaucoma, Mydriatic.

Mechanism of Action of Phenylephrine

The drug exerts it`s pharmacological action by acting as a selective alpha-1 adrenergic agonist. It causes vasoconstriction and increases total peripheral resistance and raises blood pressure. It reduces intraocular tension by constricting ciliary body blood vessels and produce mydriasis (without cycloplegia). It exerts nasal decongestant action; by vasoconstrictory action on arterioles of nasal mucosa. It prolongs and localizes the action of anaesthetics due to it`s vasoconstrictory action on skin, mucous membrane, and viscera and thus slows the rate of absorption of local anaesthetics.

Pharmacokinets of Phenylephrine

Absorption: Variable depending up on the route of administration. Metabolism: Metabolized in the liver and intestine.

Onset of Action for Phenylephrine

Nasal: Rapid
Ophthalmic: Rapid
I.V.: Rapid
I.M.: Within 15 minutes

Duration of Action for Phenylephrine

Nasal: ? to 4 hours
Ophthalmic: 3 to 7 hours
I.V.: 15 to 20 minutes
I.M.: ? to 2 hours.

Half Life of Phenylephrine

N/A

Side Effects of Phenylephrine

1.Bradycardia
2.Arrhythmias
3.Hypertension
4.Tachycardia
5.Palpitations
6.Premature ventricular contractions
7.Pallor
8.Headache
9.Dizziness
10.Nervousness
11.Brow ache(with ophthalmic form)
12.Burning or stinging in eye
13.Blurred vision
14.Elevated intraocular pressure
15.Nausea
16.Episodes of asthma
17.Tachyphylaxis
18.Anaphylaxis

Contra-indications of Phenylephrine

1.Hypersensitivity to the drug
2.Hyperthyroidism
3.Ventricular tachycardia and severe hypertension (Injected form)
4.Angle closure glaucoma and in those who wear soft contact lenses(ophthalmic form)

Special Precautions while taking Phenylephrine

1.Coronary diseases
2.Advanced arteriosclerosis
3.Bradycardia
4.Partial heart block
5.Myocardial diseases
6.Atherosclerosis
7.Hypertension
8.Nasal and ophthalmic form use cautiously in type-1 diabetes mellitus

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution
Below age 6:contraindicated

Indications for Phenylephrine

1.Hypotension
2.Paroxysmal supra ventricular tachycardia
3.Maintain blood pressure during spinal and inhalation anaesthesia
4.Prolongation of spinal anaesthesia
5.Shock
6.Mydriasis(without cycloplegia)
7.Nasal congestion.
8.Cataract

Interactions for Phenylephrine

May interact with systemically administered MAOIs.

Typical Dosage for Phenylephrine

I.M. or S.C.: 2 to 5mg. Then if required; give doses up to 10mg.
Slow I.V. injection: 0.1 to 0.5mg. Then if required; repeat after 15 minutes.
I.V. infusion: Starts with 0.18mg/minute. Then adjust the dosage up to 0.03 to 0.06mg/minute based on patient`s response.
Nasal congestion: Apply 2 to 3 drops or 1 to 2 sprays of 0.25% to 1% solution instilled in each nostril.
Mydriasis (without cycloplegia): Instill 1 to 2drops 2.5% or 10% solution in eye. Repeated if required.
Prolongation of spinal anaesthesia: 2 to 5mg added to anaesthetic solution.

Schedule of Phenylephrine

N/A

Storage Requirements for Phenylephrine

Store at controlled room temperature at range of 15 to 30 degree C. in a well closed container. Protect from light.

Effects of Missed Dosage of Phenylephrine

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Phenylephrine

Discontinue the drug and give supportive and symptomatic treatment. Closely monitor vital signs. Use atropine sulfate to block reflex Bradycardia. Treat excessive hypertension with phentolamine. Treat cardiac arrhythmia with propranolol. Treat excessive mydriatic effect with levodopa.

Home Delivery for Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine in Your City

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Dextromethorphan + Chlorpheniramine Maleate + Phenylephrine is a generic medicine name and there are several brands available for it. Some of the brands for dextromethorphan + chlorpheniramine maleate + phenylephrine might be better known than dextromethorphan + chlorpheniramine maleate + phenylephrine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextromethorphan + chlorpheniramine maleate + phenylephrine in stock, you can ask for one of the branded alternatives for dextromethorphan + chlorpheniramine maleate + phenylephrine.