Tricholine citrate + Cyproheptadine Pharmacology

Tricholine citrate + Cyproheptadine

About Tricholine citrate + Cyproheptadine
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Mechanism of Action of Tricholine citrate + Cyproheptadine
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Pharmacokinets of Tricholine citrate + Cyproheptadine
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Onset of Action for Tricholine citrate + Cyproheptadine
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Duration of Action for Tricholine citrate + Cyproheptadine
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Half Life of Tricholine citrate + Cyproheptadine
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Side Effects of Tricholine citrate + Cyproheptadine
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Contra-indications of Tricholine citrate + Cyproheptadine
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Special Precautions while taking Tricholine citrate + Cyproheptadine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Tricholine citrate + Cyproheptadine
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Interactions for Tricholine citrate + Cyproheptadine
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Typical Dosage for Tricholine citrate + Cyproheptadine
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Schedule of Tricholine citrate + Cyproheptadine
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Storage Requirements for Tricholine citrate + Cyproheptadine
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Effects of Missed Dosage of Tricholine citrate + Cyproheptadine
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Effects of Overdose of Tricholine citrate + Cyproheptadine
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Tricholine citrate

About Tricholine citrate
A quaternary ammonium compound, Used in liver disorders.
Mechanism of Action of Tricholine citrate
Tricholine citrate contains three molecules of choline. Due to choline`s lipotropic action, it is useful in the treatment of fatty infiltration and cirrhosis of liver. Choline converts fat into phospholipids like, lecithin, which is essential to biomembrane structure and its function. Lecithin is also a major component of high density lipoprotein (HDL), and is used to mobilize cholesterol from cell membrane. In patients with fatty liver, increased rate of phospholipid turnover has been observed following administration of choline.
Pharmacokinets of Tricholine citrate
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Onset of Action for Tricholine citrate
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Duration of Action for Tricholine citrate
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Half Life of Tricholine citrate
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Side Effects of Tricholine citrate
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Contra-indications of Tricholine citrate
1.Hypersensitivity to Tricholine citrate
Special Precautions while taking Tricholine citrate
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Tricholine citrate
1.Liver disorders
Interactions for Tricholine citrate
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Typical Dosage for Tricholine citrate
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Schedule of Tricholine citrate
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Storage Requirements for Tricholine citrate
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Effects of Missed Dosage of Tricholine citrate
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Effects of Overdose of Tricholine citrate
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Cyproheptadine

About Cyproheptadine
Piperidine (nonselective) First Generation H1 Antagonist ,anticholinergic and antiserotonergic(5-HT2 receptor antagonist), antihistaminic,appetite stimulant.
Mechanism of Action of Cyproheptadine
Cyproheptadine is a sedative antihistamine with serotonin antagonist, and calcium-channel blocking actions. It competes with Histamine for H1 receptors present in the smooth muscle of gastrointestinal tract, bronchi, large blood vessels and uterus. Histamine cannot bind with H1 receptors and cannot produce histamine induced allergic symptoms. Cyproheptadine blocks serotonin receptors preferentially block 5HT2A receptor and are useful in migraine prophylaxis. It has weak anticholinergic activity and possesses mild CNS depressant properties. It also blocks voltage sensitive calcium channel in islet of pancreas and smooth muscle. Cyproheptadine increases appetite and cause weight gain.
Pharmacokinets of Cyproheptadine
Absorption: Cyproheptadine is well absorbed after oral administration. Distribution: It is distributed in the body in highly protein bound form. Metabolism: It is extensively metabolised in the liver. Excretion: Metabolites are excreted primarily in the urine; unchanged drug and small amount of metabolites are excreted through faeces.
Onset of Action for Cyproheptadine
15 - 60 minutes
Duration of Action for Cyproheptadine
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Half Life of Cyproheptadine
1 - 4 hours
Side Effects of Cyproheptadine
1.Dizziness
2.Drowsiness
3.Fatigue
4.Nervousness
5.Sleepiness
6.Epigastric distress
7.Dry mouth
8.Nausea
9.Vomiting
10.Rash
11.Urine retention
12.Weight gain


Contra-indications of Cyproheptadine
1.Hypersensitivity to Cyproheptadine and other drugs of similar structure
2.Angle closure glaucoma
3.Acute asthma
4.Peptic ulcer
5.Bladder neck obstruction
6.Prostatic hyperplasia
7.Pyloroduodenal obstruction
8.Debilitated patients
9.Patient on monoamine oxidase inhibitory therapy.
Special Precautions while taking Cyproheptadine
1.Hypertension
2.Hyperthyroidism
3.Increased intraocular pressure
4.Bronchial asthma
5.Patient should be cautioned against activities requiring mental alertness such as driving, operating machine or involving in any hazardous activities 6.Avoid alcohol


Pregnancy Related Information
Use with caution
Old Age Related Information
Contraindicated.
Breast Feeding Related Information
Contraindicated.
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Cyproheptadine
1.Antiallergic
2.Appetite stimulant
3.Cluster headache
Interactions for Cyproheptadine
Alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, anti-anxiety drugs, narcotic analgesics): CNS depressant action potentiated.
MAOIs, tricylic antidepressants and atropine: Antimuscarinic action potentiated.
Aminoglycosides: Ototoxicity produced by aminoglycosides masked.

Typical Dosage for Cyproheptadine
Adult: 12 - 16 mg / day in 3 - 4 divided doses.
Maximum dose: 32 mg / day
Migraine prophylaxis and vascular headaches: Initial dose: 4 mg and may be repeated after 30 minutes; A maintenance dose of 4 mg may be given every 4 to 6 hours.

Children above 6 years: 8 - 12 mg / day in 2 - 3 divided doses
Maximum dose: 16 mg / day
Children 2 - 6: 4 - 6 mg / day in 2 - 3 divided doses
Maximum dose: 12 mg / day
Schedule of Cyproheptadine
G
Storage Requirements for Cyproheptadine
Store at room temperature in a tightly closed container.
Effects of Missed Dosage of Cyproheptadine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Cyproheptadine
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing vomiting. Absorption of the drug can be reduced by administration of activated charcoal. Hypotension can be treated by vasopressors and seizure with Diazepam or Phenytoin.

Home Delivery for Tricholine citrate + Cyproheptadine in Your City

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Tricholine citrate + Cyproheptadine is a generic medicine name and there are several brands available for it. Some of the brands for tricholine citrate + cyproheptadine might be better known than tricholine citrate + cyproheptadine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tricholine citrate + cyproheptadine in stock, you can ask for one of the branded alternatives for tricholine citrate + cyproheptadine.