Tricholine citrate + Cyproheptadine Pharmacology
- About Tricholine citrate
- A quaternary ammonium compound, Used in liver disorders.
- Mechanism of Action of Tricholine citrate
- Tricholine citrate contains three molecules of choline. Due to choline`s lipotropic action, it is useful in the treatment of fatty infiltration and cirrhosis of liver. Choline converts fat into phospholipids like, lecithin, which is essential to biomembrane structure and its function. Lecithin is also a major component of high density lipoprotein (HDL), and is used to mobilize cholesterol from cell membrane. In patients with fatty liver, increased rate of phospholipid turnover has been observed following administration of choline.
- Contra-indications of Tricholine citrate
- 1.Hypersensitivity to Tricholine citrate
- Indications for Tricholine citrate
- 1.Liver disorders
- About Cyproheptadine
- Piperidine (nonselective) First Generation H1 Antagonist ,anticholinergic and antiserotonergic(5-HT2 receptor antagonist), antihistaminic,appetite stimulant.
- Mechanism of Action of Cyproheptadine
- Cyproheptadine is a sedative antihistamine with serotonin antagonist, and calcium-channel blocking actions. It competes with Histamine for H1 receptors present in the smooth muscle of gastrointestinal tract, bronchi, large blood vessels and uterus. Histamine cannot bind with H1 receptors and cannot produce histamine induced allergic symptoms. Cyproheptadine blocks serotonin receptors preferentially block 5HT2A receptor and are useful in migraine prophylaxis. It has weak anticholinergic activity and possesses mild CNS depressant properties. It also blocks voltage sensitive calcium channel in islet of pancreas and smooth muscle. Cyproheptadine increases appetite and cause weight gain.
- Pharmacokinets of Cyproheptadine
- Absorption: Cyproheptadine is well absorbed after oral administration. Distribution: It is distributed in the body in highly protein bound form. Metabolism: It is extensively metabolised in the liver. Excretion: Metabolites are excreted primarily in the urine; unchanged drug and small amount of metabolites are excreted through faeces.
- Onset of Action for Cyproheptadine
- 15 - 60 minutes
- Half Life of Cyproheptadine
- 1 - 4 hours
- Side Effects of Cyproheptadine
- Contra-indications of Cyproheptadine
- 1.Hypersensitivity to Cyproheptadine and other drugs of similar structure
2.Angle closure glaucoma
5.Bladder neck obstruction
9.Patient on monoamine oxidase inhibitory therapy.
- Special Precautions while taking Cyproheptadine
3.Increased intraocular pressure
5.Patient should be cautioned against activities requiring mental alertness such as driving, operating machine or involving in any hazardous activities 6.Avoid alcohol
- Pregnancy Related Information
- Use with caution
- Old Age Related Information
- Breast Feeding Related Information
- Children Related Information
- Use with caution
- Indications for Cyproheptadine
- Interactions for Cyproheptadine
- Alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, anti-anxiety drugs, narcotic analgesics): CNS depressant action potentiated.
MAOIs, tricylic antidepressants and atropine: Antimuscarinic action potentiated.
Aminoglycosides: Ototoxicity produced by aminoglycosides masked.
- Typical Dosage for Cyproheptadine
- Adult: 12 - 16 mg / day in 3 - 4 divided doses.
Maximum dose: 32 mg / day
Migraine prophylaxis and vascular headaches: Initial dose: 4 mg and may be repeated after 30 minutes; A maintenance dose of 4 mg may be given every 4 to 6 hours.
Children above 6 years: 8 - 12 mg / day in 2 - 3 divided doses
Maximum dose: 16 mg / day
Children 2 - 6: 4 - 6 mg / day in 2 - 3 divided doses
Maximum dose: 12 mg / day
- Storage Requirements for Cyproheptadine
- Store at room temperature in a tightly closed container.
- Effects of Missed Dosage Cyproheptadine
- Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
- Effects of Overdose Cyproheptadine
- Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing vomiting. Absorption of the drug can be reduced by administration of activated charcoal. Hypotension can be treated by vasopressors and seizure with Diazepam or Phenytoin.
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