Methyl Prednisolone Pharmacology
Methyl Prednisolone
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction
Antivertigo action: Methyl Prednisolone suppresses intralabyrinthine edema due to viral infection or other causes.
2.Peptic ulcer
3.Haemorrhage
4.Glycosuria
5.Hyperglycaemia
6.Osteoporosis
7.Atrophy of adrenal cortex(on prolonged therapy)
8.Suppression of adrenocorticotropic hormone
9.Cushing`s syndrome
10.Inhibition of growth in children
11.Amenorrhoea
12.Behavioral disturbances
13.Thromboembolic disorders
14.Myopathy
15.Weakness
16.Lymphocytopenia
17.Muscle wasting
18.Gastrointestinal discomfort
19.Increased appetite
20.Delayed wound healing
21.Headache
22.Euphoria
23.Insomnia
24.Seizures
25.Heart failure
26.Arrhythmias
27.Posterior sub capsular cataract
28.Glaucoma
29.Sodium and fluid retention
30.Hypo kalaemia
31.Increased intracranial pressure
2.Peptic ulcer
3.Systemic Infections
4.Fungal infections
5.Live vaccines
2.Monitor vital parameters, therapeutic response and adjust the dosage
3.Use lower dosages as much as possible
4.Tuberculosis
5.Osteoporosis
6.Ocular herpes simplex
7.Primary glaucoma
8.Peptic ulcer
9.Primary psychosis and psychoneurosis
10.Recent myocardial infarction
11.Heart failure
12.Diabetes mellitus
13.Hypothyroidism
14.Cirrhosis
15.Stress
16.Sepsis
17.Hypertension
18.Myasthenia gravis
19.Renal impairment
20.Hepatic impairment
21.Non specific Ulcerative colitis
22.Diverticulitis
23.Recent intestinal anastomosis
24.Seizures
25.Thromboembolic disorders
Neonates: Contraindicated
2.Anaphylaxis
3.Inflammatory conditions
4.Multiple sclerosis
5.Rheumatic disorders
6.Autoimmune diseases
7.Asthma
8.Transplantation
9.Malignancies
11.Dermatological conditions
12.Ulcerative colitis
13.Crohn`s disease
14.Stevens-Johnson syndrome
15.Aspiration of gastric content
16.Acute gout
17.Vertigo
Vertigo: Initial dose: 40 - 80 mg / day for 4 - 5 days, followed by 20 mg / day fro 4 days.
Multiple sclerosis:200mg/day for one week; followed by 80mg every other day for one month.
Inflammation: 2 to 60mg/day in four divided doses depending up on the severity of the condition and patient`s response.
Allergic condition, Asthma, and Dermatological conditions: 40 to 120mg/day depending up on the severity of the condition and patient`s response.
Intralesional injection: 4 to 80mg depending up on the size of the lesion and severity of the condition.
I.V. or I.M.:
Allergic conditions, Ulcerative colitis, Crohn`s disease, Stevens-Johnson syndrome, Multiple sclerosis, Aspiration of gastric content, Transplantation, Cerebral oedema associated with tumor:
Starts with 10 to 500mg I.M. or slow I.V. infusion over half an hour; depending up on the severity of the condition. In transplant patients up to 1g/day, In multiple sclerosis 1g/day up to 3 days.
Oral
Children: 0.5mg/kg/day to 30mg/kg/day depending up on the disease type and severity of the condition.
Transplantation: 10 to 20mg/kg/day for 3days.
Asthma: 1 to 4mg/kg/day for 1 to 3 days.
Vertigo : 2 to 4mg/kg/day in 4 to 6 divided doses.
Home Delivery for Methyl Prednisolone in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including methyl prednisolone.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for methyl prednisolone and other medicines and health products. Home delivery services for methyl prednisolone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take methyl prednisolone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for methyl prednisolone before they complete the sale. You can get this information while placing the order for methyl prednisolone with the pharmacy.
Methyl Prednisolone is a generic medicine name and there are several brands available for it. Some of the brands for methyl prednisolone might be better known than methyl prednisolone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have methyl prednisolone in stock, you can ask for one of the branded alternatives for methyl prednisolone.
