Itopride Pharmacology

Itopride

About Itopride

Dopamine(D2) antagonist, a prokinetic benzamide derivative, Motility stimulant.

Mechanism of Action of Itopride

Itopride has three way action. It inhibits the dopamine D2 receptor at the parasympathetic nerve ends.It increases the release of acetycholine and decreases the metabolism of acetylcholine by inhibiting the enzyme acetylcholinesterase (AChE). By maintaining higher acetylcholine levels, itopride increases the oesophageal and gastrointestinal peristalsis, increases the lower oesophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying and improves gastro-duodenal coordination. Itopride exerts anti-emetic actions because of its dopamine D2 receptor antagonistic action at CTZ.

Pharmacokinets of Itopride

Absorption: it is orally well absorbed after oral administration.Metabolism: Itopride undergoes extensive hepatic metabolism.

Onset of Action for Itopride

N/A

Duration of Action for Itopride

N/A

Half Life of Itopride

5 - 6 hours

Side Effects of Itopride

1.Diarrhoea
2.Abdominal pain
3.Headache
4.Constipation
5.Irritated feeling
6.Giddiness

Contra-indications of Itopride

1.Hypersensitivity to Itopride
2.Gastrointestinal haemorrhage
3.Mechanical obstruction or perforation

Special Precautions while taking Itopride

N/A

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution
Below12 years: Contraindicated

Indications for Itopride

1.Gastro oesophageal reflux diseases
2.Diabetic Gastroparesis
3.Non ulcer dyspepsia
4.Chronic gastritis

Interactions for Itopride

Cisapride, atropine.

Typical Dosage for Itopride

Adult-Oral: 50 mg 3 times daily taken before each meal

Schedule of Itopride

N/A

Storage Requirements for Itopride

Store the drug below 30 degree C. Protect from heat and light.

Effects of Missed Dosage of Itopride

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Itopride

Give supportive measures and symptomatic treatment.

Home Delivery for Itopride in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including itopride.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for itopride and other medicines and health products. Home delivery services for itopride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take itopride only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for itopride before they complete the sale. You can get this information while placing the order for itopride with the pharmacy.

Itopride is a generic medicine name and there are several brands available for it. Some of the brands for itopride might be better known than itopride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have itopride in stock, you can ask for one of the branded alternatives for itopride.