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- Pharmacology For Dutasteride + Tamsulosin
Dutasteride + Tamsulosin Pharmacology
Dutasteride + Tamsulosin
About Dutasteride + TamsulosinN/AMechanism of Action of Dutasteride + TamsulosinTamsulosin is a selective ?-1 adrenoceptor blocker. It blocks ?-1 adrenoceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck, resulting relaxation of these adrenoceptors in the bladder neck and prostate. Thus, there is an improvement in urine flow rate and reduction in symptoms of benign prostatic hypertrophy (BPH). Dutasteride inhibits 5 ?-reductase, the enzyme responsible for conversion of testosterone to 5?-dihydrotestosterone (DHT). DHT appears to be the principal androgen responsible for stimulation of prostatic growth.Pharmacokinets of Dutasteride + TamsulosinN/AOnset of Action for Dutasteride + TamsulosinN/ADuration of Action for Dutasteride + TamsulosinN/AHalf Life of Dutasteride + TamsulosinN/ASide Effects of Dutasteride + Tamsulosin1.Impotence
2.Decreased libido
3.Ejaculation disorders
4.Breast tenderness and enlargement
5.Postural hypotension
6.Dizziness and vertigo
7.Headache
8.Infection
9.Asthenia
10.Back pain
11.Chest pain
12.Somnolence
13.Insomnia
14.Rhinitis
15.Pharyngitis
16.Cough
17.Sinusitis
18.Diarrhea
19.Nausea
20.Tooth disorder
21.Blurred vision
Contra-indications of Dutasteride + Tamsulosin1.Hypersensitivity
2.Severe liver impairment
Special Precautions while taking Dutasteride + Tamsulosin1.Excreted in semen therefore use of condom is recommended
2.Women of childbearing potential should avoid handling leaking capsules of dutasteride
3.Prostate carcinoma should be ruled out before starting the therapy
4.Blood donation to be avoided during and at least 6 mths after discontinuance of drug
Pregnancy Related InformationContraindicated since Dutasteride is contraindicated in pregnancyOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated since Dutasteride and Tamsulosin are contraindicated in lactationChildren Related InformationContraindicated Indications for Dutasteride + TamsulosinBenign prostatic hyperplasia (BPH)Interactions for Dutasteride + Tamsulosin1.Concomitant admin with moderate or strong inhibitors of CYP2D6 (eg. fluoxetine) or CYP34A (eg. ketoconazole, cimetidine) increases tamsulosin serum concentration.
2.Increase in blood concentrations of dutasteride in the presence of inhibitors of CYP3A4/5 such as ritonavir, ketoconazole, verapamil, diltiazem, cimetidine, troleandomycin, and ciprofloxacin.
Typical Dosage for Dutasteride + Tamsulosin1 tablet / daySchedule of Dutasteride + TamsulosinN/AStorage Requirements for Dutasteride + TamsulosinN/AEffects of Missed Dosage of Dutasteride + TamsulosinN/AEffects of Overdose of Dutasteride + TamsulosinN/ADutasteride
About DutasterideA 5-alpha-reductase inhibitor, In benign prostatic hyperplasia(BPH),male baldness.Mechanism of Action of DutasterideThis is a selective inhibitor of both type 1 and type 2 isoforms of steroid 5alpha-reductase (an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone which influences the development of prostate gland). This decreasing level of this hormone relieves the symptoms associated with benign prostatic hyperplasia.Pharmacokinets of DutasterideAbsorption - Moderately absorbed after oral administration
Distribution- Widely distributed in the body as protein binding (99%) form
Metabolism- Metabolized in the liver.
Excretion- Excreted via fecal route
Onset of Action for DutasterideN/ADuration of Action for DutasterideN/AHalf Life of Dutasteride5 weeksSide Effects of Dutasteride1. Inability to have or maintain an erection
2. Decrease in sex drive
3. Difficulty ejaculating
4. Breast tenderness or enlargement
Contra-indications of Dutasteride1. Hypersensitivity to the drug
2. Cancer of the prostate
3. Liver disease
4. Problems with urination
Special Precautions while taking Dutasteride1.Dutasteride is intended for use by men only.
2.Take each dose with a full glass of water.
3.Swallow the capsules whole. Do not chew, crush or break the capsules
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Dutasteride1. Benign prostatic hyperplasia (BPH)
2. Male pattern baldness
Interactions for DutasterideN/ATypical Dosage for DutasterideOral-
Adults-
For benign prostatic hyperplasia- 0.5 milligram (mg) once a day
Schedule of DutasterideN/AStorage Requirements for DutasterideStore at room temperature (25 degree C) away from light and moistureEffects of Missed Dosage of DutasterideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DutasterideGive symptomatic and supportive treatmentTamsulosin
About TamsulosinSelective Alpha1a Adrenergic Antagonist , For benign prostatic hyperplasia.Mechanism of Action of TamsulosinTamsulosin is adrenergic alpha receptor antagonist. It inhibits alpha 1A and alpha 1D subtype receptors. Tamsulosin selectively inhibits alpha 1A receptor in the prostate and leads to relaxation of smooth muscles in the bladder neck and prostate. This will improve urine flow and reduces BPH symptoms.
Adrenergic nerves releases adrenalin which produces contraction of muscles. Tamsulosin is selectively inhibit alpha 1A receptor in the prostate and bladder neck and relaxes the muscles and decrease the obstruction to the flow of urine in prostate hypertrophy.
Pharmacokinets of TamsulosinAbsorption: It is well absorbed after oral administration under fasting condition.
Distribution: It is distributed widely to tissues in protein bound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: The drug and its metabolites are excreted primarily in the urine and about 21% is excreted through faeces.
Onset of Action for TamsulosinN/ADuration of Action for Tamsulosin9 - 15 hoursHalf Life of Tamsulosin5- 10 hoursSide Effects of Tamsulosin1. Dizziness
2. Headache
3. Abnormal ejaculation
4. Vertigo
5. Postural hypotension
6. Somnolence
7. Insomnia
8. Diarrhoea
9. Nausea
10. Back pain
11. Syncope
12. Infection
13. Rhinitis
14. Sinusitis
15. Pharyngitis
16. Rash
17. Pruritis
18. Urticaria
Contra-indications of Tamsulosin1. Hypersensitivity to TamsulosinSpecial Precautions while taking Tamsulosin1. During initiation of therapy slowly get up from chair or bed.
2. Avoid conditions in which injury could occur as a result of syncope.
3. Driving vehicle, operating machine and other hazardous woks.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: ContraindicatedIndications for Tamsulosin1. Benign Prostatic hyperplasia (BPH)
Interactions for TamsulosinCimetidine: Results in significant decrease in clearance of tamsulosin AUC.
Alpha adrenergic blocking agents: Tamsulosin should not be used in combination with other alpha adrenergics.
Typical Dosage for TamsulosinAdult: 400mg / day drug to be taken 30 minutes after the same meal each day and if sufficient response does not obtained then increase the dose to 800mg / day after 2 or 4 weeks.
Children: Not recommended
Schedule of TamsulosinN/AStorage Requirements for TamsulosinStore at room temperature. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of TamsulosinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. If treatment with Tamsulosin is missed for several days, contact doctor before restarting the medication and a lower dose may be necessary to restart the drug.Effects of Overdose of TamsulosinGive supportive measures and symptomatic treatment. Administer IV fluids and if needed give vasopressors. Monitor renal functions.Home Delivery for Dutasteride + Tamsulosin in Your City
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Dutasteride + Tamsulosin is a generic medicine name and there are several brands available for it. Some of the brands for dutasteride + tamsulosin might be better known than dutasteride + tamsulosin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dutasteride + tamsulosin in stock, you can ask for one of the branded alternatives for dutasteride + tamsulosin.