Mupirocin + Betamethasone dipropionate Pharmacology

Mupirocin + Betamethasone dipropionate

About Mupirocin + Betamethasone dipropionate
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Mechanism of Action of Mupirocin + Betamethasone dipropionate
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Pharmacokinets of Mupirocin + Betamethasone dipropionate
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Onset of Action for Mupirocin + Betamethasone dipropionate
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Duration of Action for Mupirocin + Betamethasone dipropionate
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Half Life of Mupirocin + Betamethasone dipropionate
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Side Effects of Mupirocin + Betamethasone dipropionate
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Contra-indications of Mupirocin + Betamethasone dipropionate
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Special Precautions while taking Mupirocin + Betamethasone dipropionate
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Mupirocin + Betamethasone dipropionate
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Interactions for Mupirocin + Betamethasone dipropionate
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Typical Dosage for Mupirocin + Betamethasone dipropionate
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Schedule of Mupirocin + Betamethasone dipropionate
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Storage Requirements for Mupirocin + Betamethasone dipropionate
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Effects of Missed Dosage of Mupirocin + Betamethasone dipropionate
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Effects of Overdose of Mupirocin + Betamethasone dipropionate
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Mupirocin

About Mupirocin
A naturally antibiotic isolated from Pseudomonas fluorescens, Antibiotic.
Mechanism of Action of Mupirocin
Mupirocin exerts its action by reversibly binding to isoleucyl transfer RNA synthetase and inhibits the enzyme activity. This enzyme is necessary for the synthesis of proteins in the bacteria. Inhibition of isoleucyl transfer RNA synthetase results in inhibition of protein synthesis and produce microbicidal action. It is more active against gram positive bacteria as compared to gram negative bacteria.
Pharmacokinets of Mupirocin
Absorption: Mupirocin is negligibly absorbed after topical administration.
Onset of Action for Mupirocin
N/A
Duration of Action for Mupirocin
N/A
Half Life of Mupirocin
N/A
Side Effects of Mupirocin
Topical use :
1. Irritation
2. Burning
3. Rashes
4. Pruritis
5. Stinging
6. Erythema
7. Dryness
8. Dermatitis
9. Pain
Nasal use:
1. Rhinitis
2. Cough
3. Headache
4. Pharyngitis
5. Change in taste
6. Chest congestion
Contra-indications of Mupirocin
1. Hypersensitivity to Mupirocin
Special Precautions while taking Mupirocin
1. If sensitivity occurs discard the use of the medicament
2. Renal impairment
3. Patient with burns
4. Avoid contact with eyes and mucous membrane
5. Avoid application in the large surface area(extensive wound)
6. Monitor for super infection
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Use with caution
Indications for Mupirocin
Bacterial skin infections:
1. Impetigo
2. Infected eczema
3. Folliculitis
4. Eradication of nasal colonization of Methicillin resistant S.aureus
Interactions for Mupirocin
N/A
Typical Dosage for Mupirocin
Adult:
Topical use: 2% cream, and ointment: Wash and dry the affected area thoroughly. Apply the medicament as a thin film over the affected part. Rub gently. Cover with a surgical gauze. Apply 3 times daily for 1 - 2 weeks.
Intranasal use: 2 % ointment: Apply the half of the content of a single use tube in to one nostril and other half in to other nostril. Press the sides of the nostrils together and release it. Repeat it for 1 minute. Apply it morning and evening.
Schedule of Mupirocin
N/A
Storage Requirements for Mupirocin
Store at room temperature in a tightly closed container. Keep away from moisture and heat. Keep out of the reach of children.
Effects of Missed Dosage of Mupirocin
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Mupirocin
Give supportive measures and symptomatic treatment.

Betamethasone dipropionate

About Betamethasone dipropionate
A synthetic glucocorticoid, anti-inflammatory.
Mechanism of Action of Betamethasone dipropionate
The drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Betamethasone dipropionate
Absorption: It is absorbed in to the systemic circulation and the amount is depending on the potency, amount applied and the nature of the skin at the site of application. Absorption increases at the site of skin damage, inflammation or occlusion.

Onset of Action for Betamethasone dipropionate
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Duration of Action for Betamethasone dipropionate
N/A
Half Life of Betamethasone dipropionate
N/A
Side Effects of Betamethasone dipropionate
1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Betamethasone dipropionate
1.Hypersensitivity to Betamethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Betamethasone dipropionate
1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Betamethasone dipropionate
1.Eczema
2.Psoriasis
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Betamethasone dipropionate
N/A
Typical Dosage for Betamethasone dipropionate
Apply thinly 1 -2 times daily.
Schedule of Betamethasone dipropionate
H
Storage Requirements for Betamethasone dipropionate
Store at room temperature in a well closed; light resistant container. Protect from excess heat and moisture. Keep out of reach of children.
Effects of Missed Dosage of Betamethasone dipropionate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Betamethasone dipropionate
Provide symptomatic treatment and supportive measures.

Home Delivery for Mupirocin + Betamethasone dipropionate in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mupirocin + betamethasone dipropionate and other medicines and health products. Home delivery services for mupirocin + betamethasone dipropionate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mupirocin + betamethasone dipropionate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mupirocin + betamethasone dipropionate before they complete the sale. You can get this information while placing the order for mupirocin + betamethasone dipropionate with the pharmacy.

Mupirocin + Betamethasone dipropionate is a generic medicine name and there are several brands available for it. Some of the brands for mupirocin + betamethasone dipropionate might be better known than mupirocin + betamethasone dipropionate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mupirocin + betamethasone dipropionate in stock, you can ask for one of the branded alternatives for mupirocin + betamethasone dipropionate.