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- Pharmacology For Roxithromycin + Ambroxol
Roxithromycin + Ambroxol Pharmacology
Roxithromycin + Ambroxol
About Roxithromycin + AmbroxolN/AMechanism of Action of Roxithromycin + AmbroxolN/APharmacokinets of Roxithromycin + AmbroxolN/AOnset of Action for Roxithromycin + AmbroxolN/ADuration of Action for Roxithromycin + AmbroxolN/AHalf Life of Roxithromycin + AmbroxolN/ASide Effects of Roxithromycin + AmbroxolN/AContra-indications of Roxithromycin + AmbroxolN/ASpecial Precautions while taking Roxithromycin + AmbroxolN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Roxithromycin + AmbroxolN/AInteractions for Roxithromycin + AmbroxolN/ATypical Dosage for Roxithromycin + AmbroxolN/ASchedule of Roxithromycin + AmbroxolN/AStorage Requirements for Roxithromycin + AmbroxolN/AEffects of Missed Dosage of Roxithromycin + AmbroxolN/AEffects of Overdose of Roxithromycin + AmbroxolN/ARoxithromycin
About RoxithromycinIt is a semi-synthetic macrolide, Antibiotic.Mechanism of Action of RoxithromycinRoxithromycin is a semi synthetic long acting macrolide antibiotic. It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie: they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Pharmacokinets of RoxithromycinAbsorption: Roxithromycin is absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form. Metabolism: small portion undergo metabolism.
Excretion: It is primarily excreted through bile and also excreted through urine and breast milk
Onset of Action for Roxithromycin1 - 2 hoursDuration of Action for Roxithromycin8 - 12 hoursHalf Life of RoxithromycinN/ASide Effects of Roxithromycin1. Nausea
2. Vomiting
3. Diarrhoea
4. Epigastric pain
5. Fever
6. Rash
7. Urticaria
8. Increase in liver enzyme concentrations
Contra-indications of Roxithromycin1. Hypersensitivity to Roxithromycin and other macrolide
2. Use of ergotamine type compound along with Roxithromycin
Special Precautions while taking Roxithromycin1. Hepatic dysfunctionPregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Roxithromycin1. Pneumonia
2. Tonsilitis
3. Pharyngitis
4. Bronchitis
5. ENT infection
6. Tetanus
7. Diphtheria
8. Sinusitis
9. Gonorrhea
10. Wound and burn infection
11. Skin and soft tissue infections
12. Pertusis
13. Urogenital infection
Interactions for RoxithromycinDigoxin: Increases absorption.
Midazolam: Increases its half-life.
Terfenadine: Serum levels elevated leading to ventricular arrhythmias.
Disopyramide: Displaced from its protein bound sites.Typical Dosage for RoxithromycinAdult: 300 mg in two divided dose for 1 - 2 week
Children: 4 - 8 mg/kg body weight/day in divided dose
Schedule of RoxithromycinHStorage Requirements for RoxithromycinStore in a cool dark place. Keep away from heat and moisture.Effects of Missed Dosage of RoxithromycinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of RoxithromycinGive supportive measures and treatmentAmbroxol
About AmbroxolActive N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.Mechanism of Action of AmbroxolAmbroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.Pharmacokinets of AmbroxolN/AOnset of Action for AmbroxolN/ADuration of Action for AmbroxolN/AHalf Life of AmbroxolN/ASide Effects of Ambroxol1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.Contra-indications of AmbroxolHypersensitivity to the Ambroxol hydrochloride or Bromhexine.Special Precautions while taking Ambroxol1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ambroxol1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.Interactions for AmbroxolN/ATypical Dosage for AmbroxolOral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of AmbroxolHStorage Requirements for AmbroxolStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of AmbroxolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmbroxolProvide symptomatic treatment and supportive measures.Home Delivery for Roxithromycin + Ambroxol in Your City
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Please be aware that you should take roxithromycin + ambroxol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for roxithromycin + ambroxol before they complete the sale. You can get this information while placing the order for roxithromycin + ambroxol with the pharmacy.
Roxithromycin + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for roxithromycin + ambroxol might be better known than roxithromycin + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have roxithromycin + ambroxol in stock, you can ask for one of the branded alternatives for roxithromycin + ambroxol.