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- Pharmacology For Dextromethorphan + Guaiphenesin
Dextromethorphan + Guaiphenesin Pharmacology
Dextromethorphan + GuaiphenesinAbout Dextromethorphan + GuaiphenesinN/AMechanism of Action of Dextromethorphan + GuaiphenesinN/APharmacokinets of Dextromethorphan + GuaiphenesinN/AOnset of Action for Dextromethorphan + GuaiphenesinN/ADuration of Action for Dextromethorphan + GuaiphenesinN/AHalf Life of Dextromethorphan + GuaiphenesinN/ASide Effects of Dextromethorphan + GuaiphenesinN/AContra-indications of Dextromethorphan + GuaiphenesinN/ASpecial Precautions while taking Dextromethorphan + GuaiphenesinN/APregnancy Related InformationContraindicated; since Dextromethorphan is contraindicated in pregnancy the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Dextromethorphan + GuaiphenesinIt is a combination of antitussive Dextromethoraphan and expectorant Guaiphensin.
Interactions for Dextromethorphan + GuaiphenesinN/ATypical Dosage for Dextromethorphan + GuaiphenesinOral
Adult: 5 - 10 ml to be taken 3 - 4 times daily
Schedule of Dextromethorphan + GuaiphenesinN/AStorage Requirements for Dextromethorphan + GuaiphenesinN/AEffects of Missed Dosage of Dextromethorphan + GuaiphenesinN/AEffects of Overdose of Dextromethorphan + GuaiphenesinN/A
DextromethorphanAbout DextromethorphanA synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.Mechanism of Action of DextromethorphanDextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))Pharmacokinets of DextromethorphanAbsorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.Onset of Action for DextromethorphanBelow ? an hourDuration of Action for Dextromethorphan3 to 6 hoursHalf Life of Dextromethorphan11 hoursSide Effects of Dextromethorphan1. Dizziness
4. Stomach pain
6. Ataxia.Contra-indications of DextromethorphanPatients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.Special Precautions while taking Dextromethorphan1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin
Pregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationMay be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated
Indications for DextromethorphanChronic nonproductive cough.Interactions for DextromethorphanN/ATypical Dosage for DextromethorphanOral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.
Schedule of DextromethorphanN/AStorage Requirements for DextromethorphanStore at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of DextromethorphanTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DextromethorphanRemove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.
GuaiphenesinAbout GuaiphenesinPropanediol derivative, Expectorant.Mechanism of Action of GuaiphenesinGuaiphenesin is an expectorant which after absorption from the gastrointestinal tract secreted by tracheobronchial glands and directly increase bronchial secretion and mucosal ciliary action. It increases respiratory tract fluid by reducing adhesiveness and surface tension, reducing viscosity of the secretions and there by facilitating their removal and clears chest congestion.
Action in local vaginal preparations: Guaiphenesin helps to thin the thick or sticky cervical mucus.
Pharmacokinets of GuaiphenesinAbsorption: Well absorbed orally.Distribution: It is secreted by the tracheobronchial glands.
Metabolism: It is metabolized primarily to Beta-2-methoxyphenoxy-lactic acid. Excretion: It is excreted in the urine.
Onset of Action for GuaiphenesinN/ADuration of Action for GuaiphenesinN/AHalf Life of Guaiphenesin60 minutesSide Effects of Guaiphenesin1. Headache
8. Stomach pain
Contra-indications of Guaiphenesin1. Hypersensitivity to the drug
2. Chronic or persistent cough associated with chronic lower respiratory tract diseases
5. Chronic obstructive pulmonary disease (COPD)
Special Precautions while taking Guaiphenesin1. Porphyria
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationMay be usedIndications for Guaiphenesin1. Expectorant
2. Thick or sticky cervical mucus
Interactions for GuaiphenesinN/ATypical Dosage for GuaiphenesinOral :
Adults and children over 12 years: 100 to 400mg up to 6 times daily as required.Maximum dose: 2.4g/day
Children (age 6 to 11): 100 to 200mg up to 6 times daily as required.Maximum dose: 1.2g/day
Children (age 2 to 5): 50 to 100mg up to 6 times daily as required.Maximum dose: 600mg/day
Adults and children over 12 years: 600 to 1200mg twice daily. Not to exceed 2.4g in 24 hours
Children (age 6 to 12): 600mg twice daily. Not to exceed 1.2g in 24 hours
Children (age 2 to 6): 300mg twice daily. Not to exceed 600mg in 24 hours
Thick or sticky cervical mucus: 200mg 2 to 3 times daily from 4 days prior to ovulation and continue through ovulation day.
Schedule of GuaiphenesinN/AStorage Requirements for GuaiphenesinStore at a temperature below 30 degree C. Keep out of reach of children.Effects of Missed Dosage of GuaiphenesinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of GuaiphenesinProvide symptomatic treatment and supportive measures.
Home Delivery for Dextromethorphan + Guaiphenesin in Your City
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Dextromethorphan + Guaiphenesin is a generic medicine name and there are several brands available for it. Some of the brands for dextromethorphan + guaiphenesin might be better known than dextromethorphan + guaiphenesin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextromethorphan + guaiphenesin in stock, you can ask for one of the branded alternatives for dextromethorphan + guaiphenesin.