Desloratadine + Pseudoephedrine + Ambroxol Pharmacology

Desloratadine + Pseudoephedrine + Ambroxol

About Desloratadine + Pseudoephedrine + Ambroxol
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Mechanism of Action of Desloratadine + Pseudoephedrine + Ambroxol
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Pharmacokinets of Desloratadine + Pseudoephedrine + Ambroxol
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Onset of Action for Desloratadine + Pseudoephedrine + Ambroxol
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Duration of Action for Desloratadine + Pseudoephedrine + Ambroxol
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Half Life of Desloratadine + Pseudoephedrine + Ambroxol
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Side Effects of Desloratadine + Pseudoephedrine + Ambroxol
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Contra-indications of Desloratadine + Pseudoephedrine + Ambroxol
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Special Precautions while taking Desloratadine + Pseudoephedrine + Ambroxol
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Desloratadine + Pseudoephedrine + Ambroxol
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Interactions for Desloratadine + Pseudoephedrine + Ambroxol
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Typical Dosage for Desloratadine + Pseudoephedrine + Ambroxol
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Schedule of Desloratadine + Pseudoephedrine + Ambroxol
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Storage Requirements for Desloratadine + Pseudoephedrine + Ambroxol
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Effects of Missed Dosage of Desloratadine + Pseudoephedrine + Ambroxol
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Effects of Overdose of Desloratadine + Pseudoephedrine + Ambroxol
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Desloratadine

About Desloratadine
Second Generation long-acting tricyclic H1 Antagonist, Antihistamine.
Mechanism of Action of Desloratadine
This second generation antihistamine has a selective peripheral H1-antagonist action.Desloratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This inhibit the action of histamine, which subsequently leads to temporary relief of the negative symptoms brought by histamine
Pharmacokinets of Desloratadine
Absorption- Rapidly absorbed after oral administration
Distribution- Widely distributed in the body. 85% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excrete through urine (40% as conjugated form) and feces

Onset of Action for Desloratadine
N/A
Duration of Action for Desloratadine
N/A
Half Life of Desloratadine
Its plasma half life is 50hrs
Side Effects of Desloratadine
1. Dizziness
2. Dry mouth
3. Dysmenorrhea
4. Dyspepsia
5. Belching
6. Heartburn
7. Indigestion
8. Stomach discomfort
9. Fatigue
10. Myalgia
11. Difficulty in moving
12. Pharyngitis
13. Fever
14. Hoarseness
15. Runny nose
16. Tender swollen glands in neck
17. Trouble in swallowing
18. Voice changes
19. Somnolence
20. Nausea
Contra-indications of Desloratadine
1. Dizziness
2. Dry mouth
3. Dysmenorrhea
4. Dyspepsia
5. Belching
6. Heartburn
7. Iindigestion
8. Stomach discomfort
9. Fatigue
10. Myalgia
11. Difficulty in moving
12. Pharyngitis
13. Fever
14. Hoarseness
15. Runny nose
16. Tender swollen glands in neck
17. Trouble in swallowing
18. Voice changes
19. Somnolence
20. Nausea
Special Precautions while taking Desloratadine
1. Liver disease
2. Kidney disease
3. Phenylketonuria
4. Any work which require mental alertness such as driving and machine operation
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Desloratadine
1. Hay fever
2. Watery eyes
3. Runny nose
4. Itching eyes
5. Sneezing
6. Hives
7. Decongestant
Interactions for Desloratadine
N/A
Typical Dosage for Desloratadine
Oral-
Adult (general dose)-
5mg/day
Children (>12yrs)-Same as adult
Schedule of Desloratadine
N/A
Storage Requirements for Desloratadine
Stored at room temperature. Protect from light and excessive heat. Keep out of reach of children
Effects of Missed Dosage of Desloratadine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Desloratadine
Give symptomatic and supportive treatment

Pseudoephedrine

About Pseudoephedrine
Alpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.
Mechanism of Action of Pseudoephedrine
It is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.
Pharmacokinets of Pseudoephedrine
Absorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.
Onset of Action for Pseudoephedrine
30 minutes
Duration of Action for Pseudoephedrine
4 to 8 hours
Half Life of Pseudoephedrine
N/A
Side Effects of Pseudoephedrine
1. Rise in blood pressure
2. Tachycardia
3. Arrhythmias
4. CNS stimulation
5. Restlessness
6. Insomnia
7. Anxiety
8. Tremors
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine
1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 years
Special Precautions while taking Pseudoephedrine
1. Hypertension
2. Cardiac diseases
3. Diabetes
4. Glaucoma
5. Prostatic hyperplasia
6. Hyperthyroidism

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Pseudoephedrine
1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infections
Interactions for Pseudoephedrine
N/A
Typical Dosage for Pseudoephedrine
Oral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.

Schedule of Pseudoephedrine
N/A
Storage Requirements for Pseudoephedrine
Store at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of children
Effects of Missed Dosage of Pseudoephedrine
Take the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of Pseudoephedrine
Continue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.

Ambroxol

About Ambroxol
Active N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.
Mechanism of Action of Ambroxol
Ambroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.
Pharmacokinets of Ambroxol
N/A
Onset of Action for Ambroxol
N/A
Duration of Action for Ambroxol
N/A
Half Life of Ambroxol
N/A
Side Effects of Ambroxol
1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.
Contra-indications of Ambroxol
Hypersensitivity to the Ambroxol hydrochloride or Bromhexine.
Special Precautions while taking Ambroxol
1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Ambroxol
1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.
Interactions for Ambroxol
N/A
Typical Dosage for Ambroxol
Oral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of Ambroxol
H
Storage Requirements for Ambroxol
Store in a cool dry place and protect from light. Keep out of reach of children.
Effects of Missed Dosage of Ambroxol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ambroxol
Provide symptomatic treatment and supportive measures.

Home Delivery for Desloratadine + Pseudoephedrine + Ambroxol in Your City

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Desloratadine + Pseudoephedrine + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for desloratadine + pseudoephedrine + ambroxol might be better known than desloratadine + pseudoephedrine + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have desloratadine + pseudoephedrine + ambroxol in stock, you can ask for one of the branded alternatives for desloratadine + pseudoephedrine + ambroxol.