Phenylephrine + Chlorpheniramine Maleate + Bromhexine Pharmacology

Phenylephrine + Chlorpheniramine Maleate + Bromhexine

About Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Mechanism of Action of Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Pharmacokinets of Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Onset of Action for Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Duration of Action for Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Half Life of Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Side Effects of Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Contra-indications of Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Special Precautions while taking Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Interactions for Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Typical Dosage for Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Schedule of Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Storage Requirements for Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Effects of Missed Dosage of Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A
Effects of Overdose of Phenylephrine + Chlorpheniramine Maleate + Bromhexine
N/A

Phenylephrine

About Phenylephrine
An a1-adrenergic receptor agonist, Phenethylamine derivative, Decongestant, Antiglaucoma, Mydriatic.
Mechanism of Action of Phenylephrine
The drug exerts it`s pharmacological action by acting as a selective alpha-1 adrenergic agonist. It causes vasoconstriction and increases total peripheral resistance and raises blood pressure. It reduces intraocular tension by constricting ciliary body blood vessels and produce mydriasis (without cycloplegia). It exerts nasal decongestant action; by vasoconstrictory action on arterioles of nasal mucosa. It prolongs and localizes the action of anaesthetics due to it`s vasoconstrictory action on skin, mucous membrane, and viscera and thus slows the rate of absorption of local anaesthetics.
Pharmacokinets of Phenylephrine
Absorption: Variable depending up on the route of administration. Metabolism: Metabolized in the liver and intestine.
Onset of Action for Phenylephrine
Nasal: Rapid
Ophthalmic: Rapid
I.V.: Rapid
I.M.: Within 15 minutes
Duration of Action for Phenylephrine
Nasal: ? to 4 hours
Ophthalmic: 3 to 7 hours
I.V.: 15 to 20 minutes
I.M.: ? to 2 hours.


Half Life of Phenylephrine
N/A
Side Effects of Phenylephrine
1.Bradycardia
2.Arrhythmias
3.Hypertension
4.Tachycardia
5.Palpitations
6.Premature ventricular contractions
7.Pallor
8.Headache
9.Dizziness
10.Nervousness
11.Brow ache(with ophthalmic form)
12.Burning or stinging in eye
13.Blurred vision
14.Elevated intraocular pressure
15.Nausea
16.Episodes of asthma
17.Tachyphylaxis
18.Anaphylaxis


Contra-indications of Phenylephrine
1.Hypersensitivity to the drug
2.Hyperthyroidism
3.Ventricular tachycardia and severe hypertension (Injected form)
4.Angle closure glaucoma and in those who wear soft contact lenses(ophthalmic form)
Special Precautions while taking Phenylephrine
1.Coronary diseases
2.Advanced arteriosclerosis
3.Bradycardia
4.Partial heart block
5.Myocardial diseases
6.Atherosclerosis
7.Hypertension
8.Nasal and ophthalmic form use cautiously in type-1 diabetes mellitus

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below age 6:contraindicated
Indications for Phenylephrine
1.Hypotension
2.Paroxysmal supra ventricular tachycardia
3.Maintain blood pressure during spinal and inhalation anaesthesia
4.Prolongation of spinal anaesthesia
5.Shock
6.Mydriasis(without cycloplegia)
7.Nasal congestion.
8.Cataract

Interactions for Phenylephrine
May interact with systemically administered MAOIs.
Typical Dosage for Phenylephrine
I.M. or S.C.: 2 to 5mg. Then if required; give doses up to 10mg.
Slow I.V. injection: 0.1 to 0.5mg. Then if required; repeat after 15 minutes.
I.V. infusion: Starts with 0.18mg/minute. Then adjust the dosage up to 0.03 to 0.06mg/minute based on patient`s response.
Nasal congestion: Apply 2 to 3 drops or 1 to 2 sprays of 0.25% to 1% solution instilled in each nostril.
Mydriasis (without cycloplegia): Instill 1 to 2drops 2.5% or 10% solution in eye. Repeated if required.
Prolongation of spinal anaesthesia: 2 to 5mg added to anaesthetic solution.
Schedule of Phenylephrine
N/A
Storage Requirements for Phenylephrine
Store at controlled room temperature at range of 15 to 30 degree C. in a well closed container. Protect from light.
Effects of Missed Dosage of Phenylephrine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Phenylephrine
Discontinue the drug and give supportive and symptomatic treatment. Closely monitor vital signs. Use atropine sulfate to block reflex Bradycardia. Treat excessive hypertension with phentolamine. Treat cardiac arrhythmia with propranolol. Treat excessive mydriatic effect with levodopa.

Chlorpheniramine Maleate

About Chlorpheniramine Maleate
N/A
Mechanism of Action of Chlorpheniramine Maleate
N/A
Pharmacokinets of Chlorpheniramine Maleate
N/A
Onset of Action for Chlorpheniramine Maleate
N/A
Duration of Action for Chlorpheniramine Maleate
N/A
Half Life of Chlorpheniramine Maleate
N/A
Side Effects of Chlorpheniramine Maleate
N/A
Contra-indications of Chlorpheniramine Maleate
First Generation alkylamine H1 Antagonist, Antihistamine.
Special Precautions while taking Chlorpheniramine Maleate
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Chlorpheniramine Maleate
N/A
Interactions for Chlorpheniramine Maleate
N/A
Typical Dosage for Chlorpheniramine Maleate
N/A
Schedule of Chlorpheniramine Maleate
N/A
Storage Requirements for Chlorpheniramine Maleate
N/A
Effects of Missed Dosage of Chlorpheniramine Maleate
N/A
Effects of Overdose of Chlorpheniramine Maleate
N/A

Bromhexine

About Bromhexine
Mucolytic (secretolytic)
Mechanism of Action of Bromhexine
Bromhexine hydrochloride acts as a mucokinetic and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and network of fibres in tenacious sputum is broken. It induces thin copious bronchial secretion.
Pharmacokinets of Bromhexine
Absorption: Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and bioavailability is about 20%. Distribution: It is widely distributed to body tissues in a highly protein bound form; Bromhexine crosses the blood brain barrier and small amounts cross the placenta, Metabolism: It undergoes extensive first-pass metabolism in the liver. Excretion: It is excreted primarily in the urine mainly as metabolites.
Onset of Action for Bromhexine
N/A
Duration of Action for Bromhexine
N/A
Half Life of Bromhexine
12hours.
Side Effects of Bromhexine
1 Rhinorrhoea
2 Lacrimations
3.Allergic reactions
4.Gastric irritation.
Contra-indications of Bromhexine
Hypersensitivity to the drug.
Special Precautions while taking Bromhexine
1. Hepatic impairment
2. Renal impairment
3. Gastric and duodenal ulcer
4. Convulsive disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Bromhexine
1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10.Chronic Pneumonia.
Interactions for Bromhexine
N/A
Typical Dosage for Bromhexine
Oral: 8mg thrice daily.
Children (5 to 10 years): 4mg thrice daily
Children (1 to 5 years): 4mg twice daily.
Schedule of Bromhexine
H
Storage Requirements for Bromhexine
Store in a cool dry place and protect from light. Keep out of reach of children.
Effects of Missed Dosage of Bromhexine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Bromhexine
Provide symptomatic treatment and supportive measures.

Home Delivery for Phenylephrine + Chlorpheniramine Maleate + Bromhexine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including phenylephrine + chlorpheniramine maleate + bromhexine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for phenylephrine + chlorpheniramine maleate + bromhexine and other medicines and health products. Home delivery services for phenylephrine + chlorpheniramine maleate + bromhexine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take phenylephrine + chlorpheniramine maleate + bromhexine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for phenylephrine + chlorpheniramine maleate + bromhexine before they complete the sale. You can get this information while placing the order for phenylephrine + chlorpheniramine maleate + bromhexine with the pharmacy.

Phenylephrine + Chlorpheniramine Maleate + Bromhexine is a generic medicine name and there are several brands available for it. Some of the brands for phenylephrine + chlorpheniramine maleate + bromhexine might be better known than phenylephrine + chlorpheniramine maleate + bromhexine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have phenylephrine + chlorpheniramine maleate + bromhexine in stock, you can ask for one of the branded alternatives for phenylephrine + chlorpheniramine maleate + bromhexine.