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- Pharmacology For Pseudoephedrine + Bromhexine
Pseudoephedrine + Bromhexine Pharmacology
Pseudoephedrine + BromhexineAbout Pseudoephedrine + BromhexineN/AMechanism of Action of Pseudoephedrine + BromhexineN/APharmacokinets of Pseudoephedrine + BromhexineN/AOnset of Action for Pseudoephedrine + BromhexineN/ADuration of Action for Pseudoephedrine + BromhexineN/AHalf Life of Pseudoephedrine + BromhexineN/ASide Effects of Pseudoephedrine + BromhexineN/AContra-indications of Pseudoephedrine + BromhexineN/ASpecial Precautions while taking Pseudoephedrine + BromhexineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Pseudoephedrine + BromhexineN/AInteractions for Pseudoephedrine + BromhexineN/ATypical Dosage for Pseudoephedrine + BromhexineN/ASchedule of Pseudoephedrine + BromhexineN/AStorage Requirements for Pseudoephedrine + BromhexineN/AEffects of Missed Dosage of Pseudoephedrine + BromhexineN/AEffects of Overdose of Pseudoephedrine + BromhexineN/A
PseudoephedrineAbout PseudoephedrineAlpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.Mechanism of Action of PseudoephedrineIt is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.Pharmacokinets of PseudoephedrineAbsorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.Onset of Action for Pseudoephedrine30 minutesDuration of Action for Pseudoephedrine4 to 8 hoursHalf Life of PseudoephedrineN/ASide Effects of Pseudoephedrine1. Rise in blood pressure
4. CNS stimulation
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 yearsSpecial Precautions while taking Pseudoephedrine1. Hypertension
2. Cardiac diseases
5. Prostatic hyperplasia
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Pseudoephedrine1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infectionsInteractions for PseudoephedrineN/ATypical Dosage for PseudoephedrineOral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.
Schedule of PseudoephedrineN/AStorage Requirements for PseudoephedrineStore at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of childrenEffects of Missed Dosage of PseudoephedrineTake the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of PseudoephedrineContinue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.
BromhexineAbout BromhexineMucolytic (secretolytic)Mechanism of Action of BromhexineBromhexine hydrochloride acts as a mucokinetic and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and network of fibres in tenacious sputum is broken. It induces thin copious bronchial secretion.Pharmacokinets of BromhexineAbsorption: Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and bioavailability is about 20%. Distribution: It is widely distributed to body tissues in a highly protein bound form; Bromhexine crosses the blood brain barrier and small amounts cross the placenta, Metabolism: It undergoes extensive first-pass metabolism in the liver. Excretion: It is excreted primarily in the urine mainly as metabolites.Onset of Action for BromhexineN/ADuration of Action for BromhexineN/AHalf Life of Bromhexine12hours.Side Effects of Bromhexine1 Rhinorrhoea
4.Gastric irritation.Contra-indications of BromhexineHypersensitivity to the drug.Special Precautions while taking Bromhexine1. Hepatic impairment
2. Renal impairment
3. Gastric and duodenal ulcer
4. Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Bromhexine1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10.Chronic Pneumonia.Interactions for BromhexineN/ATypical Dosage for BromhexineOral: 8mg thrice daily.
Children (5 to 10 years): 4mg thrice daily
Children (1 to 5 years): 4mg twice daily.
Schedule of BromhexineHStorage Requirements for BromhexineStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of BromhexineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of BromhexineProvide symptomatic treatment and supportive measures.
Home Delivery for Pseudoephedrine + Bromhexine in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pseudoephedrine + bromhexine and other medicines and health products. Home delivery services for pseudoephedrine + bromhexine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
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Pseudoephedrine + Bromhexine is a generic medicine name and there are several brands available for it. Some of the brands for pseudoephedrine + bromhexine might be better known than pseudoephedrine + bromhexine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pseudoephedrine + bromhexine in stock, you can ask for one of the branded alternatives for pseudoephedrine + bromhexine.