Ambroxol +Salbutamol Pharmacology

Ambroxol +Salbutamol

About Ambroxol +Salbutamol
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Mechanism of Action of Ambroxol +Salbutamol
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Pharmacokinets of Ambroxol +Salbutamol
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Onset of Action for Ambroxol +Salbutamol
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Duration of Action for Ambroxol +Salbutamol
N/A
Half Life of Ambroxol +Salbutamol
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Side Effects of Ambroxol +Salbutamol
N/A
Contra-indications of Ambroxol +Salbutamol
N/A
Special Precautions while taking Ambroxol +Salbutamol
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Ambroxol +Salbutamol
It is a combination of Beta stimulant Salbutamol and mucolytic Ambroxol.
1.Cough associated with bronchitis, bronchial asthma, emphysema and other bronchopulmonary disorders
Interactions for Ambroxol +Salbutamol
N/A
Typical Dosage for Ambroxol +Salbutamol
Adults: 10 - 20 ml to be taken 3 times daily
Children (6-12 years): 10 ml to be taken 3 times daily
Children (under 6 years): 5-10 ml to be taken 3 times daily
Schedule of Ambroxol +Salbutamol
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Storage Requirements for Ambroxol +Salbutamol
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Effects of Missed Dosage of Ambroxol +Salbutamol
N/A
Effects of Overdose of Ambroxol +Salbutamol
N/A

Ambroxol

About Ambroxol
Active N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.
Mechanism of Action of Ambroxol
Ambroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.
Pharmacokinets of Ambroxol
N/A
Onset of Action for Ambroxol
N/A
Duration of Action for Ambroxol
N/A
Half Life of Ambroxol
N/A
Side Effects of Ambroxol
1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.
Contra-indications of Ambroxol
Hypersensitivity to the Ambroxol hydrochloride or Bromhexine.
Special Precautions while taking Ambroxol
1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Ambroxol
1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.
Interactions for Ambroxol
N/A
Typical Dosage for Ambroxol
Oral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of Ambroxol
H
Storage Requirements for Ambroxol
Store in a cool dry place and protect from light. Keep out of reach of children.
Effects of Missed Dosage of Ambroxol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ambroxol
Provide symptomatic treatment and supportive measures.

Salbutamol

About Salbutamol
Beta2-Adrenergic Agonist, Phenethylamine derivative, Bronchodilator(Antiasthma), uterine relaxant.
Mechanism of Action of Salbutamol
Salbutamol is a short acting ?2 receptor agonist. It selectively stimulates ?2 receptors present in airway, Uterus, and Vascular Smooth muscles. It directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2+sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles.
?2 receptor agonists also suppress the release of Leukotrienes and histamine from the mast cells in the lung tissue and enhance mucociliary function and decrease micro vascular permeability and also inhibits Phospholipase A2 which produces inhibition of prostaglandins production. Thus Salbutamol can inhibit the broncho-constriction produced by inflammatory mediators. Salbutamol is effective in the management of preterm labour.
Pharmacokinets of Salbutamol
Absorption: It is well absorbed after oral administration.
Distribution: Salbutamol does not cross the blood brain barrier.
Metabolism: It is metabolised to inactive metabolites in the liver
Excretion: Salbutamol is excreted primarily in the urine and small amount in the faeces.
Onset of Action for Salbutamol
15 - 30 minutes
Duration of Action for Salbutamol
6 - 12 hours
Half Life of Salbutamol
4 hours
Side Effects of Salbutamol
1. Drowsiness
2. Headache
3. Dizziness
4. Nervousness
5. Tremor
6. Weakness
7. Palpitations
8. Tachycardia
9. Arrhythmia
10. Vomiting
11. Nausea
12. Heartburn
13. Diaphoresis
14. Hypokalaemia (high dose)

Contra-indications of Salbutamol
1.Hypersensitivity to Salbutamol and other sympathomimetic amines.
Special Precautions while taking Salbutamol
1. Myocardial insufficiency
2. Arrhythmia
3. Hypertension
4. Hyperthyroidism
5. Epilepsy
6. Diabetes
Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution
Below 6 years: contraindicated
Indications for Salbutamol
1. Obstructive airway diseases
2. Acute Bronchospasm
3. Status asthmaticus
4. Premature labour
Interactions for Salbutamol
Beclomethasone, Theophylline: Enhances respiratory function.
Beta-blockers: Inhibit bronchodilator effect.
Diuretics and Xanthines: Increased risk of hypokalemia.
Digitalis: Increased risk of digitalis toxicity when salbutamol is given in hilgh doses due to hypokalaemia.
Typical Dosage for Salbutamol
Adult:
Oral:
Immediate release tablet: 2 - 4 mg every 6 - 8 hours daily, maximum dose 32mg / day
Sustained release tablets: 8 mg / day in 2 divided doses and if sufficient response does not obtained then dose can be gradually increased to 16mg / day in 2 divided doses
Children: 6 - 14 years
Syrup: 6 - 8mg / day in 3 - 4 divided doses and if needed dose can be increased maximum up to 24mg / day
Uterine Relaxant: (I.V) 4 to 32 mcg/minutes

Schedule of Salbutamol
H
Storage Requirements for Salbutamol
Store at 15 - 30 degree C. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Salbutamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Salbutamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of drug can be reduced by administration of activated charcoal.

Home Delivery for Ambroxol +Salbutamol in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ambroxol +salbutamol and other medicines and health products. Home delivery services for ambroxol +salbutamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ambroxol +salbutamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ambroxol +salbutamol before they complete the sale. You can get this information while placing the order for ambroxol +salbutamol with the pharmacy.

Ambroxol +Salbutamol is a generic medicine name and there are several brands available for it. Some of the brands for ambroxol +salbutamol might be better known than ambroxol +salbutamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ambroxol +salbutamol in stock, you can ask for one of the branded alternatives for ambroxol +salbutamol.