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- Pharmacology For Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + Bromhexine
Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + Bromhexine Pharmacology
Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + Bromhexine
About Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/AMechanism of Action of Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/APharmacokinets of Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/AOnset of Action for Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/ADuration of Action for Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/AHalf Life of Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/ASide Effects of Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/AContra-indications of Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/ASpecial Precautions while taking Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineCoughInteractions for Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/ATypical Dosage for Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineOral
Adult: 10 - 15 ml to be taken 3 times daily
Schedule of Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/AStorage Requirements for Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/AEffects of Missed Dosage of Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/AEffects of Overdose of Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + BromhexineN/ADextromethorphan
About DextromethorphanA synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.Mechanism of Action of DextromethorphanDextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))Pharmacokinets of DextromethorphanAbsorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.Onset of Action for DextromethorphanBelow ? an hourDuration of Action for Dextromethorphan3 to 6 hoursHalf Life of Dextromethorphan11 hoursSide Effects of Dextromethorphan1. Dizziness
2. Nausea
3. Vomiting
4. Stomach pain
5. Drowsiness
6. Ataxia.Contra-indications of DextromethorphanPatients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.Special Precautions while taking Dextromethorphan1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin
Pregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationMay be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated
Indications for DextromethorphanChronic nonproductive cough.Interactions for DextromethorphanN/ATypical Dosage for DextromethorphanOral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.
Schedule of DextromethorphanN/AStorage Requirements for DextromethorphanStore at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of DextromethorphanTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DextromethorphanRemove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.Ephedrine
About EphedrineAlpha/Beta Adrenergic Agonist , Sympathomimetic amine, Stimulant, vasopressor(parenteral), bronchodilator.Mechanism of Action of EphedrineEphedrine is a mixed acting sympathomimetic drug which mainly acting indirectly but also has some direct action on alpha and beta adrenergic receptors. It causes release of nor-epinephrine from it`s storage sites and stimulates alpha and beta adrenergic receptors. It relaxes bronchial smooth muscle by stimulating beta-2 adrenergic receptors and thus causes increased vital capacity, relief of mild bronchospasm, improved air exchange and decreased residual volume. Ephedrine produces cardiac stimulation with increased systolic and diastolic pressure when nor-epinephrine stores aren`t depleted. It produces positive inotropic effects with low doses through action on beta-1 receptors in heart. It causes vasodilatation through beta-2 receptors and vasoconstriction through alpha adrenergic receptors. Presser effects results from vasoconstriction, cardiac stimulation, and increased cardiac output. It produces nasal decongestant action by stimulating alpha receptors in blood vessels of nasal mucosa and causing vasoconstriction and nasal decongestion.Pharmacokinets of EphedrineAbsorption: Well absorbed after Oral, S.C., or I.M. administration.
Distribution: Widely distributed throughout the body
Metabolism: Slowly metabolized in liver by oxidative deamination, demethylation, aromatic hydroxylation and conjugation.
Excretion: Excreted mainly through urine as unchanged drug.
Onset of Action for EphedrineOral: 15 to 60 minutes
I.V.: 5minutes
I.M., S.C.: 10 to 20 minutes
Duration of Action for EphedrineOral: 3 to 5 hours
I.V.: 60 minutes
I.M.: S.C.: 30 to 60 minutes
Half Life of EphedrineN/ASide Effects of Ephedrine1. Arrhythmias
2. Palpitations
3. Tachycardia
4. Hypertension
5. Precordial pain
6. Insomnia
7. Nervousness
8. Headahe
9. Dizziness
10. Confusion
11. Euphoria
12. Delirium
13. Mucosal irritation
14. Dry nose and throat
15. Nausea
16. Vomiting
17. Anorexia
18. Urine retention
19. Painful urination
20. Muscle weakness
21. Diaphoresis.
Contra-indications of Ephedrine1. Hypersensitivity to the drug or other sympathomimetics
2. Severe coronary artery disease
3. Porphyria
4. Arrhythmias
5. Angina pectoris
6. Susstatial organic heart disease
7. Cardiovascular diseases
8. Angle closure glaucoma
9. Psychoneurosis
10. In those taking MAO inhibitors
Special Precautions while taking Ephedrine1. Hypertension
2. Hyperthyroidism
3. Nervous or excitable states
4. Diabetes
5. Prostatic hyperplasia
6. Diabetes
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ephedrine1. As nasal decongestant
2. As bronchodilator
3. Acute severe bronchospasm
4. Hypotension
5. Enuresis
Interactions for EphedrineN/ATypical Dosage for EphedrineOral:
Adults:
As bronchodilator or nasal decongestant:12.5 to 50mg at every 3 to 4 hours; as required. Do not exceed 150mg in 24 hours.
Orthostatic hypotension: 25mg 1 to 4 times daily as required.
Children:
Above 12 years:12.5 to 50mg at every 3 to 4 hours; as required. Do not exceed 150mg in 24 hours.
Age 6 to 12: 6.25 to 12.5mg every four hours. Do not exceed 75mg in 24 hours.
Children over 2 years: 2 to 3mg/kg/day in 4 to 6 divided doses.
Orthostatic hypotension: 3mg/kg/day divided in to 4 to 6 doses.
Enuresis: 25 to 50mg at bed time.
Nasal spray:
As nasal decongestant:
Adults and children over 12 years: 2 to 3 sprays to each nostril; not more than every four hours.
Children (age 6 to 12): 1 to 2 sprays to each nostril; not more than every four hours.
I.M., S.C., or I.V.:
Acute severe bronchospasm: 12.5 to 25mg I.M., S.C., or I.V.
Hypotension:
Adults: 25 to 50mg S.C. or I.M., or 10 to 25mg as slow I.V. bolus. A second I.M. dose of 50mg or I.V. dose of 25mg is administered if required. Repeat I.V. doses in 5 to 10minutes if required.
Maximum dose: 150mg/day.
Children: 3mg/kg/day S.C. or I.V. divided in to 4 to 6 doses
Schedule of EphedrineN/AStorage Requirements for EphedrineStore at controlled room temperature at a range of 15 to 30 degree C. in a well closed container. Protect from light.Effects of Missed Dosage of EphedrineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of EphedrineProvide supportive treatment and symptomatic measures. If patient is conscious induce emesis and reduce absorption by administration of activated charcoal. Perform gastric lavage if required. Maintain airway and blood pressure and closely monitor vital signs. Do not administer vasopressors. Beta blockers such as propranolol are used to treat arrhythmias. Use cardio selective beta blockers in asthmatic patients. Treat hypertension with Phentolamine, Seizures with paraldehyde or Diazepam, Pyrexia with seizures.
Chlorpheniramine Maleate
About Chlorpheniramine MaleateN/AMechanism of Action of Chlorpheniramine MaleateN/APharmacokinets of Chlorpheniramine MaleateN/AOnset of Action for Chlorpheniramine MaleateN/ADuration of Action for Chlorpheniramine MaleateN/AHalf Life of Chlorpheniramine MaleateN/ASide Effects of Chlorpheniramine MaleateN/AContra-indications of Chlorpheniramine MaleateFirst Generation alkylamine H1 Antagonist, Antihistamine.Special Precautions while taking Chlorpheniramine MaleateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Chlorpheniramine MaleateN/AInteractions for Chlorpheniramine MaleateN/ATypical Dosage for Chlorpheniramine MaleateN/ASchedule of Chlorpheniramine MaleateN/AStorage Requirements for Chlorpheniramine MaleateN/AEffects of Missed Dosage of Chlorpheniramine MaleateN/AEffects of Overdose of Chlorpheniramine MaleateN/ABromhexine
About BromhexineMucolytic (secretolytic)Mechanism of Action of BromhexineBromhexine hydrochloride acts as a mucokinetic and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and network of fibres in tenacious sputum is broken. It induces thin copious bronchial secretion.Pharmacokinets of BromhexineAbsorption: Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and bioavailability is about 20%. Distribution: It is widely distributed to body tissues in a highly protein bound form; Bromhexine crosses the blood brain barrier and small amounts cross the placenta, Metabolism: It undergoes extensive first-pass metabolism in the liver. Excretion: It is excreted primarily in the urine mainly as metabolites.Onset of Action for BromhexineN/ADuration of Action for BromhexineN/AHalf Life of Bromhexine12hours.Side Effects of Bromhexine1 Rhinorrhoea
2 Lacrimations
3.Allergic reactions
4.Gastric irritation.Contra-indications of BromhexineHypersensitivity to the drug.Special Precautions while taking Bromhexine1. Hepatic impairment
2. Renal impairment
3. Gastric and duodenal ulcer
4. Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Bromhexine1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10.Chronic Pneumonia.Interactions for BromhexineN/ATypical Dosage for BromhexineOral: 8mg thrice daily.
Children (5 to 10 years): 4mg thrice daily
Children (1 to 5 years): 4mg twice daily.
Schedule of BromhexineHStorage Requirements for BromhexineStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of BromhexineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of BromhexineProvide symptomatic treatment and supportive measures.Home Delivery for Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + Bromhexine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dextromethorphan + ephedrine + chlorpheniramine maleate + bromhexine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dextromethorphan + ephedrine + chlorpheniramine maleate + bromhexine and other medicines and health products. Home delivery services for dextromethorphan + ephedrine + chlorpheniramine maleate + bromhexine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take dextromethorphan + ephedrine + chlorpheniramine maleate + bromhexine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dextromethorphan + ephedrine + chlorpheniramine maleate + bromhexine before they complete the sale. You can get this information while placing the order for dextromethorphan + ephedrine + chlorpheniramine maleate + bromhexine with the pharmacy.
Dextromethorphan + Ephedrine + Chlorpheniramine Maleate + Bromhexine is a generic medicine name and there are several brands available for it. Some of the brands for dextromethorphan + ephedrine + chlorpheniramine maleate + bromhexine might be better known than dextromethorphan + ephedrine + chlorpheniramine maleate + bromhexine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextromethorphan + ephedrine + chlorpheniramine maleate + bromhexine in stock, you can ask for one of the branded alternatives for dextromethorphan + ephedrine + chlorpheniramine maleate + bromhexine.
