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- Pharmacology For Dextromethorphan + Phenylephrine + Ambroxol
Dextromethorphan + Phenylephrine + Ambroxol Pharmacology
Dextromethorphan + Phenylephrine + Ambroxol
About Dextromethorphan + Phenylephrine + AmbroxolN/AMechanism of Action of Dextromethorphan + Phenylephrine + AmbroxolN/APharmacokinets of Dextromethorphan + Phenylephrine + AmbroxolN/AOnset of Action for Dextromethorphan + Phenylephrine + AmbroxolN/ADuration of Action for Dextromethorphan + Phenylephrine + AmbroxolN/AHalf Life of Dextromethorphan + Phenylephrine + AmbroxolN/ASide Effects of Dextromethorphan + Phenylephrine + AmbroxolN/AContra-indications of Dextromethorphan + Phenylephrine + AmbroxolN/ASpecial Precautions while taking Dextromethorphan + Phenylephrine + AmbroxolN/APregnancy Related InformationContraindicated: since Dextromethorphan and Ambroxol are contraindicated in pregnancy the combination generic cannot be used in pregnancyOld Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Dextromethorphan and Ambroxol are contraindicated in breast feeding the combination generic cannot be used in breast feeding motherChildren Related InformationN/AIndications for Dextromethorphan + Phenylephrine + AmbroxolIt is a combination of antitussive Dextromethorphan, decongestant Phenylephrine and mucolytic Ambroxol.
1.Cough
2.Rhinitis
3.Bronchitis
Interactions for Dextromethorphan + Phenylephrine + AmbroxolN/ATypical Dosage for Dextromethorphan + Phenylephrine + AmbroxolOral
Adult: 5 - 10 ml to be taken every 6 - 8 hours
Children: 5 ml to be taken every 8 - 12 hours.
Schedule of Dextromethorphan + Phenylephrine + AmbroxolN/AStorage Requirements for Dextromethorphan + Phenylephrine + AmbroxolN/AEffects of Missed Dosage of Dextromethorphan + Phenylephrine + AmbroxolN/AEffects of Overdose of Dextromethorphan + Phenylephrine + AmbroxolN/ADextromethorphan
About DextromethorphanA synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.Mechanism of Action of DextromethorphanDextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))Pharmacokinets of DextromethorphanAbsorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.Onset of Action for DextromethorphanBelow ? an hourDuration of Action for Dextromethorphan3 to 6 hoursHalf Life of Dextromethorphan11 hoursSide Effects of Dextromethorphan1. Dizziness
2. Nausea
3. Vomiting
4. Stomach pain
5. Drowsiness
6. Ataxia.Contra-indications of DextromethorphanPatients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.Special Precautions while taking Dextromethorphan1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin
Pregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationMay be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated
Indications for DextromethorphanChronic nonproductive cough.Interactions for DextromethorphanN/ATypical Dosage for DextromethorphanOral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.
Schedule of DextromethorphanN/AStorage Requirements for DextromethorphanStore at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of DextromethorphanTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DextromethorphanRemove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.Phenylephrine
About PhenylephrineAn a1-adrenergic receptor agonist, Phenethylamine derivative, Decongestant, Antiglaucoma, Mydriatic.Mechanism of Action of PhenylephrineThe drug exerts it`s pharmacological action by acting as a selective alpha-1 adrenergic agonist. It causes vasoconstriction and increases total peripheral resistance and raises blood pressure. It reduces intraocular tension by constricting ciliary body blood vessels and produce mydriasis (without cycloplegia). It exerts nasal decongestant action; by vasoconstrictory action on arterioles of nasal mucosa. It prolongs and localizes the action of anaesthetics due to it`s vasoconstrictory action on skin, mucous membrane, and viscera and thus slows the rate of absorption of local anaesthetics.Pharmacokinets of PhenylephrineAbsorption: Variable depending up on the route of administration. Metabolism: Metabolized in the liver and intestine.Onset of Action for PhenylephrineNasal: Rapid
Ophthalmic: Rapid
I.V.: Rapid
I.M.: Within 15 minutes
Duration of Action for PhenylephrineNasal: ? to 4 hours
Ophthalmic: 3 to 7 hours
I.V.: 15 to 20 minutes
I.M.: ? to 2 hours.
Half Life of PhenylephrineN/ASide Effects of Phenylephrine1.Bradycardia
2.Arrhythmias
3.Hypertension
4.Tachycardia
5.Palpitations
6.Premature ventricular contractions
7.Pallor
8.Headache
9.Dizziness
10.Nervousness
11.Brow ache(with ophthalmic form)
12.Burning or stinging in eye
13.Blurred vision
14.Elevated intraocular pressure
15.Nausea
16.Episodes of asthma
17.Tachyphylaxis
18.Anaphylaxis
Contra-indications of Phenylephrine1.Hypersensitivity to the drug
2.Hyperthyroidism
3.Ventricular tachycardia and severe hypertension (Injected form)
4.Angle closure glaucoma and in those who wear soft contact lenses(ophthalmic form)
Special Precautions while taking Phenylephrine1.Coronary diseases
2.Advanced arteriosclerosis
3.Bradycardia
4.Partial heart block
5.Myocardial diseases
6.Atherosclerosis
7.Hypertension
8.Nasal and ophthalmic form use cautiously in type-1 diabetes mellitus
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below age 6:contraindicatedIndications for Phenylephrine1.Hypotension
2.Paroxysmal supra ventricular tachycardia
3.Maintain blood pressure during spinal and inhalation anaesthesia
4.Prolongation of spinal anaesthesia
5.Shock
6.Mydriasis(without cycloplegia)
7.Nasal congestion.
8.Cataract
Interactions for PhenylephrineMay interact with systemically administered MAOIs.Typical Dosage for PhenylephrineI.M. or S.C.: 2 to 5mg. Then if required; give doses up to 10mg.
Slow I.V. injection: 0.1 to 0.5mg. Then if required; repeat after 15 minutes.
I.V. infusion: Starts with 0.18mg/minute. Then adjust the dosage up to 0.03 to 0.06mg/minute based on patient`s response.
Nasal congestion: Apply 2 to 3 drops or 1 to 2 sprays of 0.25% to 1% solution instilled in each nostril.
Mydriasis (without cycloplegia): Instill 1 to 2drops 2.5% or 10% solution in eye. Repeated if required.
Prolongation of spinal anaesthesia: 2 to 5mg added to anaesthetic solution.
Schedule of PhenylephrineN/AStorage Requirements for PhenylephrineStore at controlled room temperature at range of 15 to 30 degree C. in a well closed container. Protect from light.Effects of Missed Dosage of PhenylephrineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PhenylephrineDiscontinue the drug and give supportive and symptomatic treatment. Closely monitor vital signs. Use atropine sulfate to block reflex Bradycardia. Treat excessive hypertension with phentolamine. Treat cardiac arrhythmia with propranolol. Treat excessive mydriatic effect with levodopa.
Ambroxol
About AmbroxolActive N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.Mechanism of Action of AmbroxolAmbroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.Pharmacokinets of AmbroxolN/AOnset of Action for AmbroxolN/ADuration of Action for AmbroxolN/AHalf Life of AmbroxolN/ASide Effects of Ambroxol1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.Contra-indications of AmbroxolHypersensitivity to the Ambroxol hydrochloride or Bromhexine.Special Precautions while taking Ambroxol1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ambroxol1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.Interactions for AmbroxolN/ATypical Dosage for AmbroxolOral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of AmbroxolHStorage Requirements for AmbroxolStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of AmbroxolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmbroxolProvide symptomatic treatment and supportive measures.Home Delivery for Dextromethorphan + Phenylephrine + Ambroxol in Your City
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Dextromethorphan + Phenylephrine + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for dextromethorphan + phenylephrine + ambroxol might be better known than dextromethorphan + phenylephrine + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextromethorphan + phenylephrine + ambroxol in stock, you can ask for one of the branded alternatives for dextromethorphan + phenylephrine + ambroxol.
