Dextromethorphan + Pseudoephedrine + Bromhexine Pharmacology

Dextromethorphan + Pseudoephedrine + Bromhexine

About Dextromethorphan + Pseudoephedrine + Bromhexine
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Mechanism of Action of Dextromethorphan + Pseudoephedrine + Bromhexine
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Pharmacokinets of Dextromethorphan + Pseudoephedrine + Bromhexine
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Onset of Action for Dextromethorphan + Pseudoephedrine + Bromhexine
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Duration of Action for Dextromethorphan + Pseudoephedrine + Bromhexine
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Half Life of Dextromethorphan + Pseudoephedrine + Bromhexine
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Side Effects of Dextromethorphan + Pseudoephedrine + Bromhexine
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Contra-indications of Dextromethorphan + Pseudoephedrine + Bromhexine
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Special Precautions while taking Dextromethorphan + Pseudoephedrine + Bromhexine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Dextromethorphan + Pseudoephedrine + Bromhexine
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Interactions for Dextromethorphan + Pseudoephedrine + Bromhexine
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Typical Dosage for Dextromethorphan + Pseudoephedrine + Bromhexine
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Schedule of Dextromethorphan + Pseudoephedrine + Bromhexine
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Storage Requirements for Dextromethorphan + Pseudoephedrine + Bromhexine
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Effects of Missed Dosage of Dextromethorphan + Pseudoephedrine + Bromhexine
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Effects of Overdose of Dextromethorphan + Pseudoephedrine + Bromhexine
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Dextromethorphan

About Dextromethorphan
A synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.
Mechanism of Action of Dextromethorphan
Dextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))
Pharmacokinets of Dextromethorphan
Absorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.
Onset of Action for Dextromethorphan
Below ? an hour
Duration of Action for Dextromethorphan
3 to 6 hours
Half Life of Dextromethorphan
11 hours
Side Effects of Dextromethorphan
1. Dizziness
2. Nausea
3. Vomiting
4. Stomach pain
5. Drowsiness
6. Ataxia.
Contra-indications of Dextromethorphan
Patients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.
Special Precautions while taking Dextromethorphan
1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
May be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated
Indications for Dextromethorphan
Chronic nonproductive cough.
Interactions for Dextromethorphan
N/A
Typical Dosage for Dextromethorphan
Oral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.
Schedule of Dextromethorphan
N/A
Storage Requirements for Dextromethorphan
Store at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.
Effects of Missed Dosage of Dextromethorphan
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dextromethorphan
Remove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.

Pseudoephedrine

About Pseudoephedrine
Alpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.
Mechanism of Action of Pseudoephedrine
It is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.
Pharmacokinets of Pseudoephedrine
Absorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.
Onset of Action for Pseudoephedrine
30 minutes
Duration of Action for Pseudoephedrine
4 to 8 hours
Half Life of Pseudoephedrine
N/A
Side Effects of Pseudoephedrine
1. Rise in blood pressure
2. Tachycardia
3. Arrhythmias
4. CNS stimulation
5. Restlessness
6. Insomnia
7. Anxiety
8. Tremors
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine
1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 years
Special Precautions while taking Pseudoephedrine
1. Hypertension
2. Cardiac diseases
3. Diabetes
4. Glaucoma
5. Prostatic hyperplasia
6. Hyperthyroidism

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Pseudoephedrine
1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infections
Interactions for Pseudoephedrine
N/A
Typical Dosage for Pseudoephedrine
Oral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.

Schedule of Pseudoephedrine
N/A
Storage Requirements for Pseudoephedrine
Store at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of children
Effects of Missed Dosage of Pseudoephedrine
Take the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of Pseudoephedrine
Continue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.

Bromhexine

About Bromhexine
Mucolytic (secretolytic)
Mechanism of Action of Bromhexine
Bromhexine hydrochloride acts as a mucokinetic and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and network of fibres in tenacious sputum is broken. It induces thin copious bronchial secretion.
Pharmacokinets of Bromhexine
Absorption: Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and bioavailability is about 20%. Distribution: It is widely distributed to body tissues in a highly protein bound form; Bromhexine crosses the blood brain barrier and small amounts cross the placenta, Metabolism: It undergoes extensive first-pass metabolism in the liver. Excretion: It is excreted primarily in the urine mainly as metabolites.
Onset of Action for Bromhexine
N/A
Duration of Action for Bromhexine
N/A
Half Life of Bromhexine
12hours.
Side Effects of Bromhexine
1 Rhinorrhoea
2 Lacrimations
3.Allergic reactions
4.Gastric irritation.
Contra-indications of Bromhexine
Hypersensitivity to the drug.
Special Precautions while taking Bromhexine
1. Hepatic impairment
2. Renal impairment
3. Gastric and duodenal ulcer
4. Convulsive disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Bromhexine
1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10.Chronic Pneumonia.
Interactions for Bromhexine
N/A
Typical Dosage for Bromhexine
Oral: 8mg thrice daily.
Children (5 to 10 years): 4mg thrice daily
Children (1 to 5 years): 4mg twice daily.
Schedule of Bromhexine
H
Storage Requirements for Bromhexine
Store in a cool dry place and protect from light. Keep out of reach of children.
Effects of Missed Dosage of Bromhexine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Bromhexine
Provide symptomatic treatment and supportive measures.

Home Delivery for Dextromethorphan + Pseudoephedrine + Bromhexine in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dextromethorphan + pseudoephedrine + bromhexine and other medicines and health products. Home delivery services for dextromethorphan + pseudoephedrine + bromhexine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dextromethorphan + pseudoephedrine + bromhexine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dextromethorphan + pseudoephedrine + bromhexine before they complete the sale. You can get this information while placing the order for dextromethorphan + pseudoephedrine + bromhexine with the pharmacy.

Dextromethorphan + Pseudoephedrine + Bromhexine is a generic medicine name and there are several brands available for it. Some of the brands for dextromethorphan + pseudoephedrine + bromhexine might be better known than dextromethorphan + pseudoephedrine + bromhexine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextromethorphan + pseudoephedrine + bromhexine in stock, you can ask for one of the branded alternatives for dextromethorphan + pseudoephedrine + bromhexine.