Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate Pharmacology

Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate

About Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Mechanism of Action of Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Pharmacokinets of Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Onset of Action for Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Duration of Action for Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Half Life of Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Side Effects of Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Contra-indications of Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Special Precautions while taking Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Pregnancy Related Information
Contraindicated: since Dextromethorphan, Phenylpropanolamine and Chlorpheniramine maleate are contraindicated in pregnancy the combination generic cannot be used in pregnancy.
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated; since Dextromethorphan, Guaiphensin and Chlorpheniramine maleate are contraindicated in breast feeding the combination generic cannot be used in breast feeding mother.
Children Related Information
N/A
Indications for Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
It is a combination of antitussive (Dextromethorpan), expectorant (Guaiphensin) and decongestatnt (Chlorpheniramine Maleate and Phenylpropanolamine) and broncodilator Terbutaline
1.Cough
2.Rhinitis
3.Bronchitis
Interactions for Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Typical Dosage for Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
Oral
Adult: 5 - 10 ml to be taken every 6 - 8 hours
Children: 5 ml to be taken every 8 - 12 hours.
Schedule of Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Storage Requirements for Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Effects of Missed Dosage of Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A
Effects of Overdose of Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate
N/A

Dextromethorphan

About Dextromethorphan
A synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.
Mechanism of Action of Dextromethorphan
Dextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))
Pharmacokinets of Dextromethorphan
Absorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.
Onset of Action for Dextromethorphan
Below ? an hour
Duration of Action for Dextromethorphan
3 to 6 hours
Half Life of Dextromethorphan
11 hours
Side Effects of Dextromethorphan
1. Dizziness
2. Nausea
3. Vomiting
4. Stomach pain
5. Drowsiness
6. Ataxia.
Contra-indications of Dextromethorphan
Patients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.
Special Precautions while taking Dextromethorphan
1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
May be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated
Indications for Dextromethorphan
Chronic nonproductive cough.
Interactions for Dextromethorphan
N/A
Typical Dosage for Dextromethorphan
Oral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.
Schedule of Dextromethorphan
N/A
Storage Requirements for Dextromethorphan
Store at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.
Effects of Missed Dosage of Dextromethorphan
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dextromethorphan
Remove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.

Guaiphenesin

About Guaiphenesin
Propanediol derivative, Expectorant.
Mechanism of Action of Guaiphenesin
Guaiphenesin is an expectorant which after absorption from the gastrointestinal tract secreted by tracheobronchial glands and directly increase bronchial secretion and mucosal ciliary action. It increases respiratory tract fluid by reducing adhesiveness and surface tension, reducing viscosity of the secretions and there by facilitating their removal and clears chest congestion.
Action in local vaginal preparations: Guaiphenesin helps to thin the thick or sticky cervical mucus.

Pharmacokinets of Guaiphenesin
Absorption: Well absorbed orally.Distribution: It is secreted by the tracheobronchial glands.
Metabolism: It is metabolized primarily to Beta-2-methoxyphenoxy-lactic acid. Excretion: It is excreted in the urine.
Onset of Action for Guaiphenesin
N/A
Duration of Action for Guaiphenesin
N/A
Half Life of Guaiphenesin
60 minutes
Side Effects of Guaiphenesin
1. Headache
2. Dizziness
3. Nausea
4. Vomiting
5. Rash
6. Diarrhoea
7. Drowsiness
8. Stomach pain
Contra-indications of Guaiphenesin
1. Hypersensitivity to the drug
2. Chronic or persistent cough associated with chronic lower respiratory tract diseases
3. Asthma
4. Bronchitis
5. Chronic obstructive pulmonary disease (COPD)
6. Emphysema
Special Precautions while taking Guaiphenesin
1. Porphyria
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
May be used
Indications for Guaiphenesin
1. Expectorant
2. Thick or sticky cervical mucus
Interactions for Guaiphenesin
N/A
Typical Dosage for Guaiphenesin
Oral :
Adults and children over 12 years: 100 to 400mg up to 6 times daily as required.Maximum dose: 2.4g/day
Children (age 6 to 11): 100 to 200mg up to 6 times daily as required.Maximum dose: 1.2g/day
Children (age 2 to 5): 50 to 100mg up to 6 times daily as required.Maximum dose: 600mg/day
Extended release:
Adults and children over 12 years: 600 to 1200mg twice daily. Not to exceed 2.4g in 24 hours
Children (age 6 to 12): 600mg twice daily. Not to exceed 1.2g in 24 hours
Children (age 2 to 6): 300mg twice daily. Not to exceed 600mg in 24 hours
Thick or sticky cervical mucus: 200mg 2 to 3 times daily from 4 days prior to ovulation and continue through ovulation day.
Schedule of Guaiphenesin
N/A
Storage Requirements for Guaiphenesin
Store at a temperature below 30 degree C. Keep out of reach of children.
Effects of Missed Dosage of Guaiphenesin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Guaiphenesin
Provide symptomatic treatment and supportive measures.

Phenylpropanolamine

About Phenylpropanolamine
Alfa-and Beta-adrenergic agonist, Phenethylamine derivative, a stimulant, decongestant,anorectic.
Mechanism of Action of Phenylpropanolamine
It is a mixed acting sympathomimetic amine with predominant alpha adrenergic agonistic action. It exerts nasal decongestant action by acting through alpha adrenergic receptors in the respiratory tract mucosa; and produces vasoconstriction. It temporarily reduces the swelling associated with inflammation of nasal mucosa.
Phenylpropanolamine also suppresses the appetite control center in the hypothalamus

Pharmacokinets of Phenylpropanolamine
Absorption: Well absorbed orally, Metabolism: Metabolized in to an active metabolite in liver, Excretion: Excreted mainly through urine.
Onset of Action for Phenylpropanolamine
15 to 30 minutes
Duration of Action for Phenylpropanolamine
3 hours
Half Life of Phenylpropanolamine
N/A
Side Effects of Phenylpropanolamine
1. Hypertension
2. Stroke
3. Arrhythmias
4. Renal failure
5. Rhabdomyolysis
6. Psychotic disturbances
7. Hallucinations
8. Seizures
Contra-indications of Phenylpropanolamine
1. Hypersensitivity to Phenylpropanolamine or other sympathomimetics
2. Coronary artery disease
3. Hypertension
4. Arteriosclerosis
5. Depression
6. Angle-closure glaucoma
7. Diabetes
8. Renal impairment
9. Hyperthyroidism
10. During or within 14 days of use of MAO inhibitors
11. Use as an anorexiant for children less than 12 years of age
12. Sustained-release forms during lactation and in children less than 12 years of age
Special Precautions while taking Phenylpropanolamine
1. Cardiovascular disorders
2. Mild Hypertension
3. Prostatic hypertrophy
4. Psychosis or other psychiatric disorders (Phenylpropanolamine may precipitate psychiatric disorders)
5. Not drinking large amounts of caffeine-containing beverages, such as coffee, tea, or colas
6. Do not engage in driving, using machines, or doing anything else that requires mental alertness while taking medication
7. Inform the physician if cold symptoms do not improve within 7 days or if fever is present
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Phenylpropanolamine
1. Nasal congestion

Interactions for Phenylpropanolamine
N/A
Typical Dosage for Phenylpropanolamine
Oral:
Adults:
As decongestant: 25mg every four hours or 50mg every 8 hours daily. Not to exceed 150mg/day
Anorexiant: 25mg thrice daily; 30minutes before meals.
Extended release tablets or capsules:As decongestant: 75mg twice daily
Anorexiant: 75mg once daily in the morning.
As decongestant:
Children (6 to 12 years): 12.5mg up to every four hours. Not to exceed 75mg/day
Children (2 to 6years): 6.25mg up to every four hours. Not to exceed 37.5mg/day

Schedule of Phenylpropanolamine
H
Storage Requirements for Phenylpropanolamine
Store at controlled room temperature at range of 15 to 30 degree C.; in a well closed container. Protect from light.
Effects of Missed Dosage of Phenylpropanolamine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Phenylpropanolamine
Provide symptomatic treatment and supportive measures.Remove drug from the body by induced emesis or gastric lavage. Barbiturate sedatives are sometimes used to control excessive CNS stimulation. Monitor Cardiovascular and respiratory functions. Administer intravenous fluids to control hypotension. Correct hypertension with Intravenous phentolamine or nitrates. Perform forced diuresis by acidification of urine.

Chlorpheniramine Maleate

About Chlorpheniramine Maleate
N/A
Mechanism of Action of Chlorpheniramine Maleate
N/A
Pharmacokinets of Chlorpheniramine Maleate
N/A
Onset of Action for Chlorpheniramine Maleate
N/A
Duration of Action for Chlorpheniramine Maleate
N/A
Half Life of Chlorpheniramine Maleate
N/A
Side Effects of Chlorpheniramine Maleate
N/A
Contra-indications of Chlorpheniramine Maleate
First Generation alkylamine H1 Antagonist, Antihistamine.
Special Precautions while taking Chlorpheniramine Maleate
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Chlorpheniramine Maleate
N/A
Interactions for Chlorpheniramine Maleate
N/A
Typical Dosage for Chlorpheniramine Maleate
N/A
Schedule of Chlorpheniramine Maleate
N/A
Storage Requirements for Chlorpheniramine Maleate
N/A
Effects of Missed Dosage of Chlorpheniramine Maleate
N/A
Effects of Overdose of Chlorpheniramine Maleate
N/A

Home Delivery for Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dextromethorphan + guaiphenesin + phenylpropanolamine + chlorpheniramine maleate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dextromethorphan + guaiphenesin + phenylpropanolamine + chlorpheniramine maleate and other medicines and health products. Home delivery services for dextromethorphan + guaiphenesin + phenylpropanolamine + chlorpheniramine maleate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dextromethorphan + guaiphenesin + phenylpropanolamine + chlorpheniramine maleate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dextromethorphan + guaiphenesin + phenylpropanolamine + chlorpheniramine maleate before they complete the sale. You can get this information while placing the order for dextromethorphan + guaiphenesin + phenylpropanolamine + chlorpheniramine maleate with the pharmacy.

Dextromethorphan + Guaiphenesin + Phenylpropanolamine + Chlorpheniramine Maleate is a generic medicine name and there are several brands available for it. Some of the brands for dextromethorphan + guaiphenesin + phenylpropanolamine + chlorpheniramine maleate might be better known than dextromethorphan + guaiphenesin + phenylpropanolamine + chlorpheniramine maleate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextromethorphan + guaiphenesin + phenylpropanolamine + chlorpheniramine maleate in stock, you can ask for one of the branded alternatives for dextromethorphan + guaiphenesin + phenylpropanolamine + chlorpheniramine maleate.