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- Pharmacology For Terbutaline + Guaiphenesin + Bromhexine
Terbutaline + Guaiphenesin + Bromhexine Pharmacology
Terbutaline + Guaiphenesin + BromhexineAbout Terbutaline + Guaiphenesin + BromhexineN/AMechanism of Action of Terbutaline + Guaiphenesin + BromhexineN/APharmacokinets of Terbutaline + Guaiphenesin + BromhexineN/AOnset of Action for Terbutaline + Guaiphenesin + BromhexineN/ADuration of Action for Terbutaline + Guaiphenesin + BromhexineN/AHalf Life of Terbutaline + Guaiphenesin + BromhexineN/ASide Effects of Terbutaline + Guaiphenesin + BromhexineN/AContra-indications of Terbutaline + Guaiphenesin + BromhexineN/ASpecial Precautions while taking Terbutaline + Guaiphenesin + BromhexineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Terbutaline + Guaiphenesin + BromhexineN/AInteractions for Terbutaline + Guaiphenesin + BromhexineN/ATypical Dosage for Terbutaline + Guaiphenesin + BromhexineN/ASchedule of Terbutaline + Guaiphenesin + BromhexineN/AStorage Requirements for Terbutaline + Guaiphenesin + BromhexineN/AEffects of Missed Dosage of Terbutaline + Guaiphenesin + BromhexineN/AEffects of Overdose of Terbutaline + Guaiphenesin + BromhexineN/A
TerbutalineAbout TerbutalineA ?2-adrenergic agonist,a fast-acting bronchodilator, Tocolytic,Anti asthma.Mechanism of Action of TerbutalineTerbutaline is a ?2 receptor agonist. Terbutaline directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2+sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles.
Tocolytic action: In premature labour Terbutaline relaxes uterine smooth muscles and inhibits uterine contractions.
Pharmacokinets of TerbutalineAbsorption: It is partially absorbed (about 33- 50%) after oral administration
Distribution: It is widely distributed in the body.
Metabolism: It is partially metabolised in the liver to inactive compounds.
Excretion: Drug and its metabolites are excreted mainly in urine.
Onset of Action for Terbutaline30 minutes (oral), 15 minutes (subcutaneous), 5-30 minutes (inhalation)Duration of Action for Terbutaline4- 8 hours (oral), 1.5-4 hours (subcutaneous), 3- 6 hours (inhalation).Half Life of TerbutalineN/ASide Effects of Terbutaline1. Drowsiness
14. Dry and irritated nose (inhalation)
15. Hypokalaemia (high dose)
Contra-indications of Terbutaline1. Hypersensitivity to Terbutaline and other sympathomimetic amines.Special Precautions while taking Terbutaline1. Myocardial insufficiency
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution
CHILDREN Below 12 years : contraindicated
Indications for Terbutaline1. Obstructive airway diseases
2. Acute Bronchospasm
3. Status asthmaticus
4. Premature labour
Interactions for TerbutalineOther Sympathomimetic bronchodilators or epinephrine: Combined effect on the cardiovascular system may be deleterious to the patient.
MAOIs and TCAs: Effect of terbutaline on vascular system may be potentiated.
Beta-adrenergic blocking agents: Block the pulmonary effect of terbutaline and may produce severe asthmatic attacks in asthmatic patients.
Beclomethasone, Theophylline: Synergy when used with these agents.
Food: Reduces bioavailability of terbutaline.Typical Dosage for TerbutalineAdult:
Oral: Initial dose: 7.5 mg / day in 3 divided doses, if needed dose can be increased to 15mg /day in 3 divided doses.
Subcutaneous /Intramuscular/slow IV infusion: 250 - 500mcg 3 - 4 times daily
Aerosol inhalation: 250 - 500mcg every 6 - 8 hours
Nebulised solution inhalation: 5 - 10 mg every 6 - 12 hours.
Oral: Initial dose: 2.5 mg in 2-3 times daily
Subcutaneous /Intramuscular/slow IV infusion: 10mcg /kg body weight dose can be increased to 300 mcg / day
Aerosol inhalation: 250 - 500mcg every 6 - 8 hours
Nebulised solution inhalation: 2 - 5 mg every 6 - 12 hours.
Premature labor (IV): Initial dose: 10mcg/minute and dose can be repeated until effective therapeutic response is obtained. Maximum dose: 80mcg/minute. Maintenance dose (IV dosage): Minimum effective dose for 4 hours.
Schedule of TerbutalineHStorage Requirements for TerbutalineStore at 15 - 30 degree C. Protect from heat and light.Effects of Missed Dosage of TerbutalineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TerbutalineGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of drug can be reduced by administration of activated charcoal.
GuaiphenesinAbout GuaiphenesinPropanediol derivative, Expectorant.Mechanism of Action of GuaiphenesinGuaiphenesin is an expectorant which after absorption from the gastrointestinal tract secreted by tracheobronchial glands and directly increase bronchial secretion and mucosal ciliary action. It increases respiratory tract fluid by reducing adhesiveness and surface tension, reducing viscosity of the secretions and there by facilitating their removal and clears chest congestion.
Action in local vaginal preparations: Guaiphenesin helps to thin the thick or sticky cervical mucus.
Pharmacokinets of GuaiphenesinAbsorption: Well absorbed orally.Distribution: It is secreted by the tracheobronchial glands.
Metabolism: It is metabolized primarily to Beta-2-methoxyphenoxy-lactic acid. Excretion: It is excreted in the urine.
Onset of Action for GuaiphenesinN/ADuration of Action for GuaiphenesinN/AHalf Life of Guaiphenesin60 minutesSide Effects of Guaiphenesin1. Headache
8. Stomach pain
Contra-indications of Guaiphenesin1. Hypersensitivity to the drug
2. Chronic or persistent cough associated with chronic lower respiratory tract diseases
5. Chronic obstructive pulmonary disease (COPD)
Special Precautions while taking Guaiphenesin1. Porphyria
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationMay be usedIndications for Guaiphenesin1. Expectorant
2. Thick or sticky cervical mucus
Interactions for GuaiphenesinN/ATypical Dosage for GuaiphenesinOral :
Adults and children over 12 years: 100 to 400mg up to 6 times daily as required.Maximum dose: 2.4g/day
Children (age 6 to 11): 100 to 200mg up to 6 times daily as required.Maximum dose: 1.2g/day
Children (age 2 to 5): 50 to 100mg up to 6 times daily as required.Maximum dose: 600mg/day
Adults and children over 12 years: 600 to 1200mg twice daily. Not to exceed 2.4g in 24 hours
Children (age 6 to 12): 600mg twice daily. Not to exceed 1.2g in 24 hours
Children (age 2 to 6): 300mg twice daily. Not to exceed 600mg in 24 hours
Thick or sticky cervical mucus: 200mg 2 to 3 times daily from 4 days prior to ovulation and continue through ovulation day.
Schedule of GuaiphenesinN/AStorage Requirements for GuaiphenesinStore at a temperature below 30 degree C. Keep out of reach of children.Effects of Missed Dosage of GuaiphenesinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of GuaiphenesinProvide symptomatic treatment and supportive measures.
BromhexineAbout BromhexineMucolytic (secretolytic)Mechanism of Action of BromhexineBromhexine hydrochloride acts as a mucokinetic and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and network of fibres in tenacious sputum is broken. It induces thin copious bronchial secretion.Pharmacokinets of BromhexineAbsorption: Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and bioavailability is about 20%. Distribution: It is widely distributed to body tissues in a highly protein bound form; Bromhexine crosses the blood brain barrier and small amounts cross the placenta, Metabolism: It undergoes extensive first-pass metabolism in the liver. Excretion: It is excreted primarily in the urine mainly as metabolites.Onset of Action for BromhexineN/ADuration of Action for BromhexineN/AHalf Life of Bromhexine12hours.Side Effects of Bromhexine1 Rhinorrhoea
4.Gastric irritation.Contra-indications of BromhexineHypersensitivity to the drug.Special Precautions while taking Bromhexine1. Hepatic impairment
2. Renal impairment
3. Gastric and duodenal ulcer
4. Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Bromhexine1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10.Chronic Pneumonia.Interactions for BromhexineN/ATypical Dosage for BromhexineOral: 8mg thrice daily.
Children (5 to 10 years): 4mg thrice daily
Children (1 to 5 years): 4mg twice daily.
Schedule of BromhexineHStorage Requirements for BromhexineStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of BromhexineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of BromhexineProvide symptomatic treatment and supportive measures.
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