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- Pharmacology For Paracetamol + Ibuprofen + Codeine
Paracetamol + Ibuprofen + Codeine Pharmacology
Paracetamol + Ibuprofen + CodeineAbout Paracetamol + Ibuprofen + CodeineN/AMechanism of Action of Paracetamol + Ibuprofen + CodeineN/APharmacokinets of Paracetamol + Ibuprofen + CodeineN/AOnset of Action for Paracetamol + Ibuprofen + CodeineN/ADuration of Action for Paracetamol + Ibuprofen + CodeineN/AHalf Life of Paracetamol + Ibuprofen + CodeineN/ASide Effects of Paracetamol + Ibuprofen + CodeineN/AContra-indications of Paracetamol + Ibuprofen + CodeineN/ASpecial Precautions while taking Paracetamol + Ibuprofen + CodeineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Paracetamol + Ibuprofen + CodeineN/AInteractions for Paracetamol + Ibuprofen + CodeineN/ATypical Dosage for Paracetamol + Ibuprofen + CodeineN/ASchedule of Paracetamol + Ibuprofen + CodeineN/AStorage Requirements for Paracetamol + Ibuprofen + CodeineN/AEffects of Missed Dosage of Paracetamol + Ibuprofen + CodeineN/AEffects of Overdose of Paracetamol + Ibuprofen + CodeineN/A
ParacetamolAbout ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
IbuprofenAbout IbuprofenNSAID, a propionic acid derivative, Analgesic and anti-inflammatory.Mechanism of Action of IbuprofenIbuprofen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Ibuprofen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions. It also inhibits platelet aggregation and prolongs bleeding time.Pharmacokinets of IbuprofenAbsorption: Ibuprofen is rapidly absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Ibuprofen and its metabolites are excreted mainly in the urine and some amount in bile.Onset of Action for Ibuprofen? hoursDuration of Action for Ibuprofen4-6 hours.Half Life of Ibuprofen2 hoursSide Effects of Ibuprofen1.Nausea
11.Blurring of vision
Contra-indications of Ibuprofen1.Hypersensitivity to Ibuprofen and other NSAIDs
Special Precautions while taking Ibuprofen1.Hepatic impairment
5.Pre existing asthma
Pregnancy Related InformationUse with caution
PREGNANCY in third trimester: contraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
CHILDREN below 6 months: contraindicatedIndications for Ibuprofen1.Rheumatoid arthritis
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
6.For the relief of fever, pain and inflammation in dental, minor surgery and orthopedic
10.Patent ductus arteriosus(IV)
Interactions for IbuprofenN/ATypical Dosage for IbuprofenAdult: 1.2 g / day in3 divided doses
Arthritis, gout and dental pain: 300 - 800 mg 3 times daily dose can be increased if needed.
Maximum dose: 3200 mg / day
Pain, Dysmenorrhoea: 1600 - 2400 mg / day in 4 - 6 divided doses
Fever: 600 mg / day in 3 divided doses.
Maximum dose: 1200 mg / day
For migraine: 400 -800 mg 3 times daily
Children: 15- 20 mg / kg body weight / day in 3 - 4 divided doses
Maximum dose: 40 mg / kg body weight / day
Schedule of IbuprofenHStorage Requirements for IbuprofenStore Ibuprofen at 15-30 degree C in a tightly closed light resistant container.Effects of Missed Dosage of IbuprofenTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of IbuprofenGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Excretion of the drug can be enhanced by administration of alkaline diuretics.
CodeineAbout CodeineAn opiate, methylmorphine , Narcotic analgesic, antitussive, and antidiarrheal.Mechanism of Action of CodeineCodeine exerts it`s action through opioid receptors and posses antitussive properties. It selectively and directly acts on cough centre and suppresses cough. It also posses analgesic action due to it`s agonistic action on opioid receptors.Pharmacokinets of CodeineAbsorption: Well absorbed after oral and parenteral administration. Distribution: Widely distributed in the body; it crosses placenta and also enters in to the breast milk. Metabolism: Metabolized in the liver by demethylation and glucuronide conjugation, Excretion: Excreted mainly in the urine as nor codeine and free and conjugated morphine.Onset of Action for CodeineOral: 30 to 45 minutes
I.M.: 10 to 30 minutes
S.C.: 10 to 30 minutes
Duration of Action for CodeineOral: 4 to 6 hours
I.V.: 4 to 6 hours
I.M.: 4 to 6 hours
S.C.: 4 to 6 hours
Half Life of CodeineN/ASide Effects of Codeine1. Constipation
5. Respiratory depression
11. Urine retention
15. Physical dependence.Contra-indications of Codeine1. Hypersensitivity to the drug
2. Bronchial asthma
3. Increased intracranial pressure
4. Respiratory depression
5. Paralytic ileus
6. Head injury
9. Following bowel surgery.Special Precautions while taking Codeine1. Renal impairment
2. Hepatic impairment
3. Increased CSF pressure
5. Addison`s disease
7. In deliberate individuals
8. Prostatic hypertrophy
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Codeine1. Nonproductive cough
2. Mild to moderate pain.Interactions for CodeineN/ATypical Dosage for CodeineAdults:
Nonproductive cough:10 to 20mg 4 times daily;Maximum dose: 120mg/day
Oral, S.C., I.M.:
Mild to moderate pain:15 to 60mg Orally, S.C., or I.M.;4 to 6 times daily as required by the patient.
Over 12 years: 10 to 20mg 4 times daily
Age 6 to 12: 5 to 10mg 4 times daily;Maximum dose: 60mg/day
Age 2 to 6: 1mg/kg/day as four equally divided doses and do not exceed 30mg in 24 hours.
Oral, S.C., I.M.:
Mild to moderate pain:0.5mg/kg orally every 4 to 6 hours or 0.5mg/kg S.C. or I.M.
Schedule of CodeineHStorage Requirements for CodeineStore at controlled room temperature at a range of 15 to 30 degree C and protects from light.Effects of Missed Dosage of CodeineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CodeineEstablish adequate respiratory exchange via a patent airway and ventilation as needed. Administer opioid antagonist Naloxone to reverse respiratory depression use repeatedly as required. (Naloxone shouldn`t be administered unless patient has clinically significant respiratory or cardiovascular depression.). If patient shows signs and symptoms within 2 hours of ingestion empty the stomach by gastric lavage and induced emesis. Reduce absorption by administration of activated charcoal. Closely monitor vital parameters and correct fluid and electrolyte balance. Provide symptomatic and supportive treatment.
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Paracetamol + Ibuprofen + Codeine is a generic medicine name and there are several brands available for it. Some of the brands for paracetamol + ibuprofen + codeine might be better known than paracetamol + ibuprofen + codeine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have paracetamol + ibuprofen + codeine in stock, you can ask for one of the branded alternatives for paracetamol + ibuprofen + codeine.