Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol Pharmacology

Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

About Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Mechanism of Action of Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Pharmacokinets of Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Onset of Action for Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Duration of Action for Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Half Life of Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Side Effects of Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Contra-indications of Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Special Precautions while taking Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Interactions for Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Typical Dosage for Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Schedule of Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Storage Requirements for Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Effects of Missed Dosage of Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Effects of Overdose of Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol

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Guaiphenesin

About Guaiphenesin

Propanediol derivative, Expectorant.

Mechanism of Action of Guaiphenesin

Guaiphenesin is an expectorant which after absorption from the gastrointestinal tract secreted by tracheobronchial glands and directly increase bronchial secretion and mucosal ciliary action. It increases respiratory tract fluid by reducing adhesiveness and surface tension, reducing viscosity of the secretions and there by facilitating their removal and clears chest congestion.
Action in local vaginal preparations: Guaiphenesin helps to thin the thick or sticky cervical mucus.

Pharmacokinets of Guaiphenesin

Absorption: Well absorbed orally.Distribution: It is secreted by the tracheobronchial glands.
Metabolism: It is metabolized primarily to Beta-2-methoxyphenoxy-lactic acid. Excretion: It is excreted in the urine.

Onset of Action for Guaiphenesin

N/A

Duration of Action for Guaiphenesin

N/A

Half Life of Guaiphenesin

60 minutes

Side Effects of Guaiphenesin

1. Headache
2. Dizziness
3. Nausea
4. Vomiting
5. Rash
6. Diarrhoea
7. Drowsiness
8. Stomach pain

Contra-indications of Guaiphenesin

1. Hypersensitivity to the drug
2. Chronic or persistent cough associated with chronic lower respiratory tract diseases
3. Asthma
4. Bronchitis
5. Chronic obstructive pulmonary disease (COPD)
6. Emphysema

Special Precautions while taking Guaiphenesin

1. Porphyria

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

May be used

Indications for Guaiphenesin

1. Expectorant
2. Thick or sticky cervical mucus

Interactions for Guaiphenesin

N/A

Typical Dosage for Guaiphenesin

Oral :
Adults and children over 12 years: 100 to 400mg up to 6 times daily as required.Maximum dose: 2.4g/day
Children (age 6 to 11): 100 to 200mg up to 6 times daily as required.Maximum dose: 1.2g/day
Children (age 2 to 5): 50 to 100mg up to 6 times daily as required.Maximum dose: 600mg/day
Extended release:
Adults and children over 12 years: 600 to 1200mg twice daily. Not to exceed 2.4g in 24 hours
Children (age 6 to 12): 600mg twice daily. Not to exceed 1.2g in 24 hours
Children (age 2 to 6): 300mg twice daily. Not to exceed 600mg in 24 hours
Thick or sticky cervical mucus: 200mg 2 to 3 times daily from 4 days prior to ovulation and continue through ovulation day.

Schedule of Guaiphenesin

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Storage Requirements for Guaiphenesin

Store at a temperature below 30 degree C. Keep out of reach of children.

Effects of Missed Dosage of Guaiphenesin

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Guaiphenesin

Provide symptomatic treatment and supportive measures.

Chlorpheniramine Maleate

About Chlorpheniramine Maleate

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Mechanism of Action of Chlorpheniramine Maleate

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Pharmacokinets of Chlorpheniramine Maleate

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Onset of Action for Chlorpheniramine Maleate

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Duration of Action for Chlorpheniramine Maleate

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Half Life of Chlorpheniramine Maleate

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Side Effects of Chlorpheniramine Maleate

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Contra-indications of Chlorpheniramine Maleate

First Generation alkylamine H1 Antagonist, Antihistamine.

Special Precautions while taking Chlorpheniramine Maleate

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Chlorpheniramine Maleate

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Interactions for Chlorpheniramine Maleate

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Typical Dosage for Chlorpheniramine Maleate

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Schedule of Chlorpheniramine Maleate

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Storage Requirements for Chlorpheniramine Maleate

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Effects of Missed Dosage of Chlorpheniramine Maleate

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Effects of Overdose of Chlorpheniramine Maleate

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Phenylephrine

About Phenylephrine

An a1-adrenergic receptor agonist, Phenethylamine derivative, Decongestant, Antiglaucoma, Mydriatic.

Mechanism of Action of Phenylephrine

The drug exerts it`s pharmacological action by acting as a selective alpha-1 adrenergic agonist. It causes vasoconstriction and increases total peripheral resistance and raises blood pressure. It reduces intraocular tension by constricting ciliary body blood vessels and produce mydriasis (without cycloplegia). It exerts nasal decongestant action; by vasoconstrictory action on arterioles of nasal mucosa. It prolongs and localizes the action of anaesthetics due to it`s vasoconstrictory action on skin, mucous membrane, and viscera and thus slows the rate of absorption of local anaesthetics.

Pharmacokinets of Phenylephrine

Absorption: Variable depending up on the route of administration. Metabolism: Metabolized in the liver and intestine.

Onset of Action for Phenylephrine

Nasal: Rapid
Ophthalmic: Rapid
I.V.: Rapid
I.M.: Within 15 minutes

Duration of Action for Phenylephrine

Nasal: ? to 4 hours
Ophthalmic: 3 to 7 hours
I.V.: 15 to 20 minutes
I.M.: ? to 2 hours.

Half Life of Phenylephrine

N/A

Side Effects of Phenylephrine

1.Bradycardia
2.Arrhythmias
3.Hypertension
4.Tachycardia
5.Palpitations
6.Premature ventricular contractions
7.Pallor
8.Headache
9.Dizziness
10.Nervousness
11.Brow ache(with ophthalmic form)
12.Burning or stinging in eye
13.Blurred vision
14.Elevated intraocular pressure
15.Nausea
16.Episodes of asthma
17.Tachyphylaxis
18.Anaphylaxis

Contra-indications of Phenylephrine

1.Hypersensitivity to the drug
2.Hyperthyroidism
3.Ventricular tachycardia and severe hypertension (Injected form)
4.Angle closure glaucoma and in those who wear soft contact lenses(ophthalmic form)

Special Precautions while taking Phenylephrine

1.Coronary diseases
2.Advanced arteriosclerosis
3.Bradycardia
4.Partial heart block
5.Myocardial diseases
6.Atherosclerosis
7.Hypertension
8.Nasal and ophthalmic form use cautiously in type-1 diabetes mellitus

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution
Below age 6:contraindicated

Indications for Phenylephrine

1.Hypotension
2.Paroxysmal supra ventricular tachycardia
3.Maintain blood pressure during spinal and inhalation anaesthesia
4.Prolongation of spinal anaesthesia
5.Shock
6.Mydriasis(without cycloplegia)
7.Nasal congestion.
8.Cataract

Interactions for Phenylephrine

May interact with systemically administered MAOIs.

Typical Dosage for Phenylephrine

I.M. or S.C.: 2 to 5mg. Then if required; give doses up to 10mg.
Slow I.V. injection: 0.1 to 0.5mg. Then if required; repeat after 15 minutes.
I.V. infusion: Starts with 0.18mg/minute. Then adjust the dosage up to 0.03 to 0.06mg/minute based on patient`s response.
Nasal congestion: Apply 2 to 3 drops or 1 to 2 sprays of 0.25% to 1% solution instilled in each nostril.
Mydriasis (without cycloplegia): Instill 1 to 2drops 2.5% or 10% solution in eye. Repeated if required.
Prolongation of spinal anaesthesia: 2 to 5mg added to anaesthetic solution.

Schedule of Phenylephrine

N/A

Storage Requirements for Phenylephrine

Store at controlled room temperature at range of 15 to 30 degree C. in a well closed container. Protect from light.

Effects of Missed Dosage of Phenylephrine

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Phenylephrine

Discontinue the drug and give supportive and symptomatic treatment. Closely monitor vital signs. Use atropine sulfate to block reflex Bradycardia. Treat excessive hypertension with phentolamine. Treat cardiac arrhythmia with propranolol. Treat excessive mydriatic effect with levodopa.

Ambroxol

About Ambroxol

Active N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.

Mechanism of Action of Ambroxol

Ambroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.

Pharmacokinets of Ambroxol

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Onset of Action for Ambroxol

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Duration of Action for Ambroxol

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Half Life of Ambroxol

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Side Effects of Ambroxol

1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.

Contra-indications of Ambroxol

Hypersensitivity to the Ambroxol hydrochloride or Bromhexine.

Special Precautions while taking Ambroxol

1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution

Indications for Ambroxol

1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.

Interactions for Ambroxol

N/A

Typical Dosage for Ambroxol

Oral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily

Schedule of Ambroxol

Storage Requirements for Ambroxol

Store in a cool dry place and protect from light. Keep out of reach of children.

Effects of Missed Dosage of Ambroxol

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Ambroxol

Provide symptomatic treatment and supportive measures.

Home Delivery for Guaiphenesin + Chlorpheniramine Maleate + Phenylephrine + Ambroxol in Your City

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