Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine Pharmacology

Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine

About Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
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Mechanism of Action of Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
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Pharmacokinets of Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
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Onset of Action for Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
N/A
Duration of Action for Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
N/A
Half Life of Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
N/A
Side Effects of Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
N/A
Contra-indications of Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
N/A
Special Precautions while taking Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
N/A
Interactions for Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
N/A
Typical Dosage for Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
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Schedule of Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
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Storage Requirements for Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
N/A
Effects of Missed Dosage of Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
N/A
Effects of Overdose of Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine
N/A

Guaiphenesin

About Guaiphenesin
Propanediol derivative, Expectorant.
Mechanism of Action of Guaiphenesin
Guaiphenesin is an expectorant which after absorption from the gastrointestinal tract secreted by tracheobronchial glands and directly increase bronchial secretion and mucosal ciliary action. It increases respiratory tract fluid by reducing adhesiveness and surface tension, reducing viscosity of the secretions and there by facilitating their removal and clears chest congestion.
Action in local vaginal preparations: Guaiphenesin helps to thin the thick or sticky cervical mucus.

Pharmacokinets of Guaiphenesin
Absorption: Well absorbed orally.Distribution: It is secreted by the tracheobronchial glands.
Metabolism: It is metabolized primarily to Beta-2-methoxyphenoxy-lactic acid. Excretion: It is excreted in the urine.
Onset of Action for Guaiphenesin
N/A
Duration of Action for Guaiphenesin
N/A
Half Life of Guaiphenesin
60 minutes
Side Effects of Guaiphenesin
1. Headache
2. Dizziness
3. Nausea
4. Vomiting
5. Rash
6. Diarrhoea
7. Drowsiness
8. Stomach pain
Contra-indications of Guaiphenesin
1. Hypersensitivity to the drug
2. Chronic or persistent cough associated with chronic lower respiratory tract diseases
3. Asthma
4. Bronchitis
5. Chronic obstructive pulmonary disease (COPD)
6. Emphysema
Special Precautions while taking Guaiphenesin
1. Porphyria
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
May be used
Indications for Guaiphenesin
1. Expectorant
2. Thick or sticky cervical mucus
Interactions for Guaiphenesin
N/A
Typical Dosage for Guaiphenesin
Oral :
Adults and children over 12 years: 100 to 400mg up to 6 times daily as required.Maximum dose: 2.4g/day
Children (age 6 to 11): 100 to 200mg up to 6 times daily as required.Maximum dose: 1.2g/day
Children (age 2 to 5): 50 to 100mg up to 6 times daily as required.Maximum dose: 600mg/day
Extended release:
Adults and children over 12 years: 600 to 1200mg twice daily. Not to exceed 2.4g in 24 hours
Children (age 6 to 12): 600mg twice daily. Not to exceed 1.2g in 24 hours
Children (age 2 to 6): 300mg twice daily. Not to exceed 600mg in 24 hours
Thick or sticky cervical mucus: 200mg 2 to 3 times daily from 4 days prior to ovulation and continue through ovulation day.
Schedule of Guaiphenesin
N/A
Storage Requirements for Guaiphenesin
Store at a temperature below 30 degree C. Keep out of reach of children.
Effects of Missed Dosage of Guaiphenesin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Guaiphenesin
Provide symptomatic treatment and supportive measures.

Ammonium chloride

About Ammonium chloride
Ammonium compound, Acidifier,Expectorant.
Mechanism of Action of Ammonium chloride
N/A
Pharmacokinets of Ammonium chloride
N/A
Onset of Action for Ammonium chloride
N/A
Duration of Action for Ammonium chloride
N/A
Half Life of Ammonium chloride
N/A
Side Effects of Ammonium chloride
N/A
Contra-indications of Ammonium chloride
N/A
Special Precautions while taking Ammonium chloride
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Ammonium chloride
N/A
Interactions for Ammonium chloride
N/A
Typical Dosage for Ammonium chloride
N/A
Schedule of Ammonium chloride
N/A
Storage Requirements for Ammonium chloride
N/A
Effects of Missed Dosage of Ammonium chloride
N/A
Effects of Overdose of Ammonium chloride
N/A

Chlorpheniramine Maleate

About Chlorpheniramine Maleate
N/A
Mechanism of Action of Chlorpheniramine Maleate
N/A
Pharmacokinets of Chlorpheniramine Maleate
N/A
Onset of Action for Chlorpheniramine Maleate
N/A
Duration of Action for Chlorpheniramine Maleate
N/A
Half Life of Chlorpheniramine Maleate
N/A
Side Effects of Chlorpheniramine Maleate
N/A
Contra-indications of Chlorpheniramine Maleate
First Generation alkylamine H1 Antagonist, Antihistamine.
Special Precautions while taking Chlorpheniramine Maleate
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Chlorpheniramine Maleate
N/A
Interactions for Chlorpheniramine Maleate
N/A
Typical Dosage for Chlorpheniramine Maleate
N/A
Schedule of Chlorpheniramine Maleate
N/A
Storage Requirements for Chlorpheniramine Maleate
N/A
Effects of Missed Dosage of Chlorpheniramine Maleate
N/A
Effects of Overdose of Chlorpheniramine Maleate
N/A

Phenylpropanolamine

About Phenylpropanolamine
Alfa-and Beta-adrenergic agonist, Phenethylamine derivative, a stimulant, decongestant,anorectic.
Mechanism of Action of Phenylpropanolamine
It is a mixed acting sympathomimetic amine with predominant alpha adrenergic agonistic action. It exerts nasal decongestant action by acting through alpha adrenergic receptors in the respiratory tract mucosa; and produces vasoconstriction. It temporarily reduces the swelling associated with inflammation of nasal mucosa.
Phenylpropanolamine also suppresses the appetite control center in the hypothalamus

Pharmacokinets of Phenylpropanolamine
Absorption: Well absorbed orally, Metabolism: Metabolized in to an active metabolite in liver, Excretion: Excreted mainly through urine.
Onset of Action for Phenylpropanolamine
15 to 30 minutes
Duration of Action for Phenylpropanolamine
3 hours
Half Life of Phenylpropanolamine
N/A
Side Effects of Phenylpropanolamine
1. Hypertension
2. Stroke
3. Arrhythmias
4. Renal failure
5. Rhabdomyolysis
6. Psychotic disturbances
7. Hallucinations
8. Seizures
Contra-indications of Phenylpropanolamine
1. Hypersensitivity to Phenylpropanolamine or other sympathomimetics
2. Coronary artery disease
3. Hypertension
4. Arteriosclerosis
5. Depression
6. Angle-closure glaucoma
7. Diabetes
8. Renal impairment
9. Hyperthyroidism
10. During or within 14 days of use of MAO inhibitors
11. Use as an anorexiant for children less than 12 years of age
12. Sustained-release forms during lactation and in children less than 12 years of age
Special Precautions while taking Phenylpropanolamine
1. Cardiovascular disorders
2. Mild Hypertension
3. Prostatic hypertrophy
4. Psychosis or other psychiatric disorders (Phenylpropanolamine may precipitate psychiatric disorders)
5. Not drinking large amounts of caffeine-containing beverages, such as coffee, tea, or colas
6. Do not engage in driving, using machines, or doing anything else that requires mental alertness while taking medication
7. Inform the physician if cold symptoms do not improve within 7 days or if fever is present
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Phenylpropanolamine
1. Nasal congestion

Interactions for Phenylpropanolamine
N/A
Typical Dosage for Phenylpropanolamine
Oral:
Adults:
As decongestant: 25mg every four hours or 50mg every 8 hours daily. Not to exceed 150mg/day
Anorexiant: 25mg thrice daily; 30minutes before meals.
Extended release tablets or capsules:As decongestant: 75mg twice daily
Anorexiant: 75mg once daily in the morning.
As decongestant:
Children (6 to 12 years): 12.5mg up to every four hours. Not to exceed 75mg/day
Children (2 to 6years): 6.25mg up to every four hours. Not to exceed 37.5mg/day

Schedule of Phenylpropanolamine
H
Storage Requirements for Phenylpropanolamine
Store at controlled room temperature at range of 15 to 30 degree C.; in a well closed container. Protect from light.
Effects of Missed Dosage of Phenylpropanolamine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Phenylpropanolamine
Provide symptomatic treatment and supportive measures.Remove drug from the body by induced emesis or gastric lavage. Barbiturate sedatives are sometimes used to control excessive CNS stimulation. Monitor Cardiovascular and respiratory functions. Administer intravenous fluids to control hypotension. Correct hypertension with Intravenous phentolamine or nitrates. Perform forced diuresis by acidification of urine.

Bromhexine

About Bromhexine
Mucolytic (secretolytic)
Mechanism of Action of Bromhexine
Bromhexine hydrochloride acts as a mucokinetic and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and network of fibres in tenacious sputum is broken. It induces thin copious bronchial secretion.
Pharmacokinets of Bromhexine
Absorption: Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and bioavailability is about 20%. Distribution: It is widely distributed to body tissues in a highly protein bound form; Bromhexine crosses the blood brain barrier and small amounts cross the placenta, Metabolism: It undergoes extensive first-pass metabolism in the liver. Excretion: It is excreted primarily in the urine mainly as metabolites.
Onset of Action for Bromhexine
N/A
Duration of Action for Bromhexine
N/A
Half Life of Bromhexine
12hours.
Side Effects of Bromhexine
1 Rhinorrhoea
2 Lacrimations
3.Allergic reactions
4.Gastric irritation.
Contra-indications of Bromhexine
Hypersensitivity to the drug.
Special Precautions while taking Bromhexine
1. Hepatic impairment
2. Renal impairment
3. Gastric and duodenal ulcer
4. Convulsive disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Bromhexine
1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10.Chronic Pneumonia.
Interactions for Bromhexine
N/A
Typical Dosage for Bromhexine
Oral: 8mg thrice daily.
Children (5 to 10 years): 4mg thrice daily
Children (1 to 5 years): 4mg twice daily.
Schedule of Bromhexine
H
Storage Requirements for Bromhexine
Store in a cool dry place and protect from light. Keep out of reach of children.
Effects of Missed Dosage of Bromhexine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Bromhexine
Provide symptomatic treatment and supportive measures.

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Guaiphenesin + Ammonium chloride + Chlorpheniramine Maleate + Phenylpropanolamine + Bromhexine is a generic medicine name and there are several brands available for it. Some of the brands for guaiphenesin + ammonium chloride + chlorpheniramine maleate + phenylpropanolamine + bromhexine might be better known than guaiphenesin + ammonium chloride + chlorpheniramine maleate + phenylpropanolamine + bromhexine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have guaiphenesin + ammonium chloride + chlorpheniramine maleate + phenylpropanolamine + bromhexine in stock, you can ask for one of the branded alternatives for guaiphenesin + ammonium chloride + chlorpheniramine maleate + phenylpropanolamine + bromhexine.