Orciprenaline Pharmacology

Orciprenaline

About Orciprenaline
Beta2-adrenergic receptor agonist, Phenethylamine derivative, A bronchodilator(Antiasthma), Tocolytic.
Mechanism of Action of Orciprenaline
Orciprenaline is a ?2 receptor agonist. Orciprenaline directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2+sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles. It is less selective than Albuterol or Terbutaline and it is more prone to produce cardiac stimulation.
Pharmacokinets of Orciprenaline
Absorption: It is partially absorbed after oral administration
Distribution: It is widely distributed in the body.
Metabolism: It is extensively metabolised in the liver to inactive compounds.
Excretion: Drug and its metabolites are excreted mainly in urine.
Onset of Action for Orciprenaline
15 minutes (oral), 1minutes (inhalation), 5 - 30 minutes (nebulisers)
Duration of Action for Orciprenaline
1- 4 hours (oral), 1- 2.5 hours (inhalation), 1- 2.5 hours (nebulisers)
Half Life of Orciprenaline
N/A
Side Effects of Orciprenaline
1. Drowsiness
2. Headache
3. Dizziness
4. Nervousness
5. Tremor
6. Weakness
7. Palpitations
8. Tachycardia
9. Arrhythmia
10. Vomiting
11. Nausea
12. Heartburn
13. Diaphoresis
14. Dry and irritated nose (inhalation)
15. Hypokalaemia (high dose)
Contra-indications of Orciprenaline
1. Hypersensitivity to Orciprenaline and other sympathomimetic amines
2. Tachycardia
3. Arrhythmia associated with tachycardia
4. Peripheral thrombosis
5. Profound hypoxia
Special Precautions while taking Orciprenaline
1. Myocardial insufficiency
2. Arrhythmia
3. Hypertension
4. Hyperthyroidism
5. Diabetes
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
CHILDREN Below 12 years : contraindicated
NEONATES: contraindicated
Indications for Orciprenaline
1. Bronchial asthma
2. Acute Bronchospasm
Interactions for Orciprenaline
N/A
Typical Dosage for Orciprenaline
Adult:
Oral: 60 - 80mg / day in 3 - 4 divided doses.
Aerosol inhalation: 0.65 mg / metered spray is used. Inhale 2 - 3 inhalations 3 - 4 times daily with 2 minutes interval between inhalations and maximum 12 inhalations / day.
Children:
Oral: above 9 year: same as adult dose
6 - 9 years: 30 - 40 mg / day in 3 - 4 divided doses
Below 6 years: 1.3 - 2.6 mg / kg / day in divided doses
Inhalations: above 12 years: same as adult dose
6 - 11 years: 0.1 - 0.2 ml of 5% solution is diluted with normal saline solution to 3ml administer by nebuliser

Schedule of Orciprenaline
H
Storage Requirements for Orciprenaline
Store at 15 - 30 degree C. Protect from heat and light.
Effects of Missed Dosage of Orciprenaline
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Orciprenaline
Give supportive measures and symptomatic treatment. Use cautiously cardio selective beta 1 adrenergic blocker to treat symptoms.

Home Delivery for Orciprenaline in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for orciprenaline and other medicines and health products. Home delivery services for orciprenaline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take orciprenaline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for orciprenaline before they complete the sale. You can get this information while placing the order for orciprenaline with the pharmacy.

Orciprenaline is a generic medicine name and there are several brands available for it. Some of the brands for orciprenaline might be better known than orciprenaline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have orciprenaline in stock, you can ask for one of the branded alternatives for orciprenaline.