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- Pharmacology For Paracetamol + Dextromethorphan + Carbinoxamine Maleate + Pseudoephedrine
Paracetamol + Dextromethorphan + Carbinoxamine Maleate + Pseudoephedrine Pharmacology
Paracetamol + Dextromethorphan + Carbinoxamine Maleate + Pseudoephedrine
About Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/AMechanism of Action of Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/APharmacokinets of Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/AOnset of Action for Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/ADuration of Action for Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/AHalf Life of Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/ASide Effects of Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/AContra-indications of Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/ASpecial Precautions while taking Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/AInteractions for Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/ATypical Dosage for Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/ASchedule of Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/AStorage Requirements for Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/AEffects of Missed Dosage of Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/AEffects of Overdose of Paracetamol + Dextromethorphan + Carbinoxamine Maleate + PseudoephedrineN/AParacetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Dextromethorphan
About DextromethorphanA synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.Mechanism of Action of DextromethorphanDextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))Pharmacokinets of DextromethorphanAbsorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.Onset of Action for DextromethorphanBelow ? an hourDuration of Action for Dextromethorphan3 to 6 hoursHalf Life of Dextromethorphan11 hoursSide Effects of Dextromethorphan1. Dizziness
2. Nausea
3. Vomiting
4. Stomach pain
5. Drowsiness
6. Ataxia.Contra-indications of DextromethorphanPatients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.Special Precautions while taking Dextromethorphan1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin
Pregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationMay be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated
Indications for DextromethorphanChronic nonproductive cough.Interactions for DextromethorphanN/ATypical Dosage for DextromethorphanOral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.
Schedule of DextromethorphanN/AStorage Requirements for DextromethorphanStore at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of DextromethorphanTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DextromethorphanRemove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.Carbinoxamine maleate
About Carbinoxamine maleateH1 receptor antagonist, Ethanolamine antihistamines, anticholinergic, Antihistamine.Mechanism of Action of Carbinoxamine maleateCarbinoxamine maleate exerts it`s action by acting as an H1 receptor antagonist. It antagonizes most of the pharmacological actions of Histamine and reduces allergic symptoms. It also has anticholinergic properties and reduces secretions.Pharmacokinets of Carbinoxamine maleateN/AOnset of Action for Carbinoxamine maleateN/ADuration of Action for Carbinoxamine maleateN/AHalf Life of Carbinoxamine maleate10 to 20 hoursSide Effects of Carbinoxamine maleate1.Sedation
2.Inability to concentrate
3.Diminished alertness
4.Motor incordination
5.Fatigue
6.Insomnia
7.Somnolence
8.Dry mouth
9.Urinery hesitancy
10.Alterd bowel movement.
Contra-indications of Carbinoxamine maleate1.Hypersensitivity to the drug
2.If patient used MAO inhibitors within the past two weeks
3.Narrow-angle glaucoma
4.Urinary retention
5.Peptic ulcer
6.Asthma
7.Blockage in stomach or intestines
8.Enlarged prostate
9.Overactive thyroid
10.Cardiac disease
11.High blood pressure.
Special Precautions while taking Carbinoxamine maleate1.Driving or any work requiring mental alertness
2.Avoid alcohol use
3.Along with other medication.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Carbinoxamine maleate1. Common cold
2.Sneezing
3.Runny nose
4.Itchy or watery eyes
5.Hives
6.Skin rash
7.Itching
8.Other symptoms of allergies
9.Irritant cough
10.Nausea
11.Vomiting
12.Vertigo associated with motion sickness
13.Drug-induced extrapyramidal symptoms
14.Mild cases of Parkinson`s disease.
Interactions for Carbinoxamine maleateN/ATypical Dosage for Carbinoxamine maleateDosage individualized based on severity of the condition and patient`s requirement.
Tablets:
Adults: 4 to 8 mg thrice daily
Children (Over six years): 4 to 6 mg thrice daily.
Oral Solution:
Adults: 1 or 2 teaspoonfuls (4 to 8 mg) thrice daily
Usual Child`s Dosage (about 0.2 - 0.4 mg/kg/day):
Two to three years - ? teaspoonful (2 mg) thrice daily.
Three to six years - ? to 1 teaspoonful (2 to 4 mg) thrice daily
Over six years - 1 to 1? teaspoonfuls (4 to 6 mg) thrice daily.
Schedule of Carbinoxamine maleateN/AStorage Requirements for Carbinoxamine maleateStore at room temperature at a range of 15 to 300C. Protect from moisture, light and heat. Keep out of reach of children.Effects of Missed Dosage of Carbinoxamine maleateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Carbinoxamine maleateProvide symptomatic treatment and supportive measures.Pseudoephedrine
About PseudoephedrineAlpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.Mechanism of Action of PseudoephedrineIt is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.Pharmacokinets of PseudoephedrineAbsorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.Onset of Action for Pseudoephedrine30 minutesDuration of Action for Pseudoephedrine4 to 8 hoursHalf Life of PseudoephedrineN/ASide Effects of Pseudoephedrine1. Rise in blood pressure
2. Tachycardia
3. Arrhythmias
4. CNS stimulation
5. Restlessness
6. Insomnia
7. Anxiety
8. Tremors
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 yearsSpecial Precautions while taking Pseudoephedrine1. Hypertension
2. Cardiac diseases
3. Diabetes
4. Glaucoma
5. Prostatic hyperplasia
6. Hyperthyroidism
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Pseudoephedrine1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infectionsInteractions for PseudoephedrineN/ATypical Dosage for PseudoephedrineOral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.
Schedule of PseudoephedrineN/AStorage Requirements for PseudoephedrineStore at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of childrenEffects of Missed Dosage of PseudoephedrineTake the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of PseudoephedrineContinue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.
Home Delivery for Paracetamol + Dextromethorphan + Carbinoxamine Maleate + Pseudoephedrine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including paracetamol + dextromethorphan + carbinoxamine maleate + pseudoephedrine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for paracetamol + dextromethorphan + carbinoxamine maleate + pseudoephedrine and other medicines and health products. Home delivery services for paracetamol + dextromethorphan + carbinoxamine maleate + pseudoephedrine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take paracetamol + dextromethorphan + carbinoxamine maleate + pseudoephedrine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for paracetamol + dextromethorphan + carbinoxamine maleate + pseudoephedrine before they complete the sale. You can get this information while placing the order for paracetamol + dextromethorphan + carbinoxamine maleate + pseudoephedrine with the pharmacy.
Paracetamol + Dextromethorphan + Carbinoxamine Maleate + Pseudoephedrine is a generic medicine name and there are several brands available for it. Some of the brands for paracetamol + dextromethorphan + carbinoxamine maleate + pseudoephedrine might be better known than paracetamol + dextromethorphan + carbinoxamine maleate + pseudoephedrine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have paracetamol + dextromethorphan + carbinoxamine maleate + pseudoephedrine in stock, you can ask for one of the branded alternatives for paracetamol + dextromethorphan + carbinoxamine maleate + pseudoephedrine.
